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Man1c1 mannosidase, alpha, class 1C, member 1 [ Mus musculus (house mouse) ]

Gene ID: 230815, updated on 5-Mar-2024

Summary

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Official Symbol
Man1c1provided by MGI
Official Full Name
mannosidase, alpha, class 1C, member 1provided by MGI
Primary source
MGI:MGI:2446214
See related
Ensembl:ENSMUSG00000037306 AllianceGenome:MGI:2446214
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable calcium ion binding activity and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in N-glycan processing. Predicted to act upstream of or within mannose metabolic process and proteoglycan biosynthetic process. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi membrane and endoplasmic reticulum. Is expressed in several structures, including cerebellum; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human MAN1C1 (mannosidase alpha class 1C member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 8.3), cerebellum adult (RPKM 7.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Man1c1 in Genome Data Viewer
Location:
4 D3; 4 66.88 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134289001..134432987, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134561690..134704290, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:134091101-134091402 Neighboring gene mitochondrial fission regulator 1-like Neighboring gene selenoprotein N Neighboring gene STARR-seq mESC enhancer starr_11681 Neighboring gene microRNA 6403 Neighboring gene predicted gene, 42326 Neighboring gene STARR-seq mESC enhancer starr_11682 Neighboring gene STARR-seq mESC enhancer starr_11683 Neighboring gene STARR-positive B cell enhancer ABC_E9086 Neighboring gene STARR-positive B cell enhancer ABC_E10265 Neighboring gene low density lipoprotein receptor adaptor protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E3527 Neighboring gene STARR-seq mESC enhancer starr_11687 Neighboring gene STARR-seq mESC enhancer starr_11688 Neighboring gene macoilin 1 Neighboring gene STARR-positive B cell enhancer ABC_E2718 Neighboring gene STARR-positive B cell enhancer ABC_E4682

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Respiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturation. Tremblay LO, et al. J Biol Chem, 2007 Jan 26. PMID 17121831
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mannose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mannose trimming involved in glycoprotein ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mannosyl-oligosaccharide 1,2-alpha-mannosidase IC
NP_001413017.1
NP_997120.1
XP_036019960.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426088.1 → NP_001413017.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627122, AL669982

  2. NM_207237.4 → NP_997120.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform 1

    See identical proteins and their annotated locations for NP_997120.1

    Status: VALIDATED

    Source sequence(s)
    AL627122, AL669982
    Consensus CDS
    CCDS18776.1
    UniProtKB/TrEMBL
    Q3UN34, Q6NXK9
    Related
    ENSMUSP00000050979.7, ENSMUST00000054096.13
    Conserved Domains (1) summary
    pfam01532
    Location:176 → 612
    Glyco_hydro_47; Glycosyl hydrolase family 47

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    134289001..134432987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164067.1 → XP_036019960.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform X1

    UniProtKB/TrEMBL
    Q3UN34
    Conserved Domains (1) summary
    pfam01532
    Location:176 → 656
    Glyco_hydro_47; Glycosyl hydrolase family 47
Nucleotide Protein Strain
Heading Accession and Version

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