Slc30a2 solute carrier family 30 (zinc transporter), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc30a2provided by MGI
Official Full Name: solute carrier family 30 (zinc transporter), member 2provided by MGI
Primary source: MGI:MGI:106637
See related: Ensembl:ENSMUSG00000028836 AllianceGenome:MGI:106637
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Znt2; ZnT-2
Summary: Predicted to enable identical protein binding activity and zinc ion transmembrane transporter activity. Predicted to be involved in positive regulation of sequestering of zinc ion; response to zinc ion; and zinc ion transmembrane transport. Predicted to act upstream of or within ion transport. Predicted to be located in late endosome. Predicted to be active in plasma membrane. Is expressed in adrenal gland; embryo; and lung. Orthologous to human SLC30A2 (solute carrier family 30 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 14.6), adrenal adult (RPKM 13.5) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 66.61 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (134070357..134081795)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (134343046..134354484)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study confirms that ZnT2 is important for normal breast function in women during lactation, and suggests that women who harbor defective variants in ZnT2 may be at-risk for poor lactation performance.
Title: A genetic variant in SLC30A2 causes breast dysfunction during lactation by inducing ER stress, oxidative stress and epithelial barrier defects.
ZnT2 is a novel regulator of vacuolar ATPase assembly, driving lysosome biogenesis, acidification, and tissue remodeling during the initiation of mammary gland involution.
Title: ZnT2 is critical for lysosome acidification and biogenesis during mammary gland involution.
Our data implicate ZnT2 as a critical mediator of cell death during involution and importantly, that as an initial involution signal, TNFalpha redistributes ZnT2 to lysosomes to activate LCD
Title: ZnT2 is a critical mediator of lysosomal-mediated cell death during early mammary gland involution.
dephosphorylated S296 was required to target ZnT2 to accumulate Zn in lysosomes
Title: TNFα Post-Translationally Targets ZnT2 to Accumulate Zinc in Lysosomes.
Together, these results demonstrate that ZnT2-mediated zinc transport is critical for mammary gland function, suggesting that defects in ZnT2 not only reduce milk zinc concentration but may compromise breast health
Title: Essential Role for Zinc Transporter 2 (ZnT2)-mediated Zinc Transport in Mammary Gland Development and Function during Lactation.
establish that PRL post-translationally regulates ZnT2-mediated zinc secretion in a multifactorial manner, first by enhancing zinc accumulation in vesicles to transiently enhance zinc secretion and then by activating ubiquitin-dependent ZnT2 degradation
Title: Prolactin (PRL)-stimulated ubiquitination of ZnT2 mediates a transient increase in zinc secretion followed by ZnT2 degradation in mammary epithelial cells.
Results identify ZnT2, the first Zn transporter directly associated with mitochondria and suggest that unique secretory tissues such as the mammary gland require novel mechanisms to modulate mitochondrion-specific functions.
Title: A histidine-rich motif mediates mitochondrial localization of ZnT2 to modulate mitochondrial function.
Study identified 2 distinct single nucleotide polymorphisms in SLC30A2, which encodes ZnT2. SNP1 (Leu(23)Pro)was mislocalized to lysosomes, while SNP2 (Arg(340)Cys) was mislocalized to the Golgi apparatus.
Title: Functional analysis of two single nucleotide polymorphisms in SLC30A2 (ZnT2): implications for mammary gland function and breast disease in women.
ZnT2 participates in zinc transport into pancreatic zymogen granules through a glucocorticoid pathway requiring glucocorticoid receptor and STAT5.
Title: STAT5-glucocorticoid receptor interaction and MTF-1 regulate the expression of ZnT2 (Slc30a2) in pancreatic acinar cells.
Results illustrate that prolactin regulates the transcription of ZnT2 through activation of the Jak2/STAT5 signaling pathway to assist in providing optimal zinc for secretion into milk during lactation.
Title: Prolactin regulates ZNT2 expression through the JAK2/STAT5 signaling pathway in mammary cells.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

Slc30a2 (e-PCR), detects polymorphism
- UniSTS:547332

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables zinc:proton antiporter activity	IC Inferred by Curator more info	PubMed
enables zinc:proton antiporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into lysosome	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into mitochondrion	IDA Inferred from Direct Assay more info	PubMed
involved_in zinc ion import into organelle	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into secretory vesicle	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into zymogen granule	ISO Inferred from Sequence Orthology more info
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in secretory vesicle	ISO Inferred from Sequence Orthology more info
located_in zymogen granule membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proton-coupled zinc antiporter SLC30A2

Names: solute carrier family 30 member 2; zinc transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039677.2 → NP_001034766.1 proton-coupled zinc antiporter SLC30A2 isoform 1

See identical proteins and their annotated locations for NP_001034766.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL669982

Consensus CDS

CCDS38915.1

UniProtKB/Swiss-Prot

D3Z5N0, Q2HJ10

UniProtKB/TrEMBL

B2RWB6

Related

ENSMUSP00000101500.3, ENSMUST00000105874.9

Conserved Domains (2) summary

TIGR01297
Location:79 → 356

CDF; cation diffusion facilitator family transporter

pfam01545
Location:79 → 277

Cation_efflux; Cation efflux family
NM_001346578.1 → NP_001333507.1 proton-coupled zinc antiporter SLC30A2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK031425, AL669982

Consensus CDS

CCDS89842.1

UniProtKB/TrEMBL

D3Z5N1

Related

ENSMUSP00000101498.2, ENSMUST00000105872.8

Conserved Domains (1) summary

TIGR01297
Location:1 → 276

CDF; cation diffusion facilitator family transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

134070357..134081795

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538755.5 → XP_006538818.1 proton-coupled zinc antiporter SLC30A2 isoform X1

UniProtKB/TrEMBL

D3Z5N1

Conserved Domains (1) summary

TIGR01297
Location:1 → 276

CDF; cation diffusion facilitator family transporter