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Serinc2 serine incorporator 2 [ Mus musculus (house mouse) ]

Gene ID: 230779, updated on 11-Apr-2024

Summary

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Official Symbol
Serinc2provided by MGI
Official Full Name
serine incorporator 2provided by MGI
Primary source
MGI:MGI:1919132
See related
Ensembl:ENSMUSG00000023232 AllianceGenome:MGI:1919132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TDE2; Tde2l; FKSG84; 2310004K20Rik
Summary
Predicted to be involved in phosphatidylserine metabolic process; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; and positive regulation of serine C-palmitoyltransferase activity. Predicted to be integral component of membrane. Predicted to be active in membrane. Orthologous to human SERINC2 (serine incorporator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 101.5), colon adult (RPKM 80.2) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 63.43 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (130147289..130172993, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (130253495..130279218, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene leucine decarboxylase 1 Neighboring gene predicted gene, 46724 Neighboring gene predicted gene, 34957 Neighboring gene STARR-seq mESC enhancer starr_11521 Neighboring gene fatty acid binding protein 3, muscle and heart Neighboring gene zinc finger, CCHC domain containing 17 Neighboring gene predicted gene, 35074

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in phosphatidylserine metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine incorporator 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253386.1 → NP_001240315.1  serine incorporator 2 isoform 2

    See identical proteins and their annotated locations for NP_001240315.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AK075863, AK158914, BE956082
    Consensus CDS
    CCDS57301.1
    UniProtKB/TrEMBL
    B2KFY0
    Related
    ENSMUSP00000112535.2, ENSMUST00000122374.8
    Conserved Domains (1) summary
    pfam03348
    Location:1 → 393
    Serinc; Serine incorporator (Serinc)

  2. NM_001356465.1 → NP_001343394.1  serine incorporator 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AK075863, AK158914, AL606925, BE956082
    Consensus CDS
    CCDS57301.1
    UniProtKB/TrEMBL
    B2KFY0
    Conserved Domains (1) summary
    pfam03348
    Location:1 → 393
    Serinc; Serine incorporator (Serinc)

  3. NM_172702.3 → NP_766290.2  serine incorporator 2 isoform 1

    See identical proteins and their annotated locations for NP_766290.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA986627, BE956082, BG077215, BU511121, CB055666
    Consensus CDS
    CCDS51310.1
    UniProtKB/Swiss-Prot
    Q8K0E7
    UniProtKB/TrEMBL
    Q8C6D8
    Related
    ENSMUSP00000101618.2, ENSMUST00000105996.8
    Conserved Domains (1) summary
    pfam03348
    Location:17 → 448
    Serinc; Serine incorporator (Serinc)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    130147289..130172993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503063.3 → XP_006503126.1  serine incorporator 2 isoform X1

    See identical proteins and their annotated locations for XP_006503126.1

    UniProtKB/TrEMBL
    E9Q7Q6, Q8C6D8
    Related
    ENSMUSP00000113044.3, ENSMUST00000120126.9
    Conserved Domains (1) summary
    pfam03348
    Location:25 → 457
    Serinc; Serine incorporator (Serinc)

  2. XM_036164063.1 → XP_036019956.1  serine incorporator 2 isoform X2

    UniProtKB/TrEMBL
    B2KFY0
    Conserved Domains (1) summary
    pfam03348
    Location:1 → 393
    Serinc; Serine incorporator (Serinc)

  3. XM_006503064.5 → XP_006503127.1  serine incorporator 2 isoform X2

    See identical proteins and their annotated locations for XP_006503127.1

    UniProtKB/TrEMBL
    B2KFY0
    Conserved Domains (1) summary
    pfam03348
    Location:1 → 393
    Serinc; Serine incorporator (Serinc)

  4. XM_030253463.2 → XP_030109323.1  serine incorporator 2 isoform X2

    UniProtKB/TrEMBL
    B2KFY0
    Conserved Domains (1) summary
    pfam03348
    Location:1 → 393
    Serinc; Serine incorporator (Serinc)

  5. XM_030253461.2 → XP_030109321.1  serine incorporator 2 isoform X2

    UniProtKB/TrEMBL
    B2KFY0
    Conserved Domains (1) summary
    pfam03348
    Location:1 → 393
    Serinc; Serine incorporator (Serinc)

  6. XM_030253462.2 → XP_030109322.1  serine incorporator 2 isoform X2

    UniProtKB/TrEMBL
    B2KFY0
    Conserved Domains (1) summary
    pfam03348
    Location:1 → 393
    Serinc; Serine incorporator (Serinc)

  7. XM_006503065.5 → XP_006503128.1  serine incorporator 2 isoform X2

    See identical proteins and their annotated locations for XP_006503128.1

    UniProtKB/TrEMBL
    B2KFY0
    Conserved Domains (1) summary
    pfam03348
    Location:1 → 393
    Serinc; Serine incorporator (Serinc)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K0E7.1 GenPept UniProtKB/Swiss-Prot:Q8K0E7

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