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Epha10 Eph receptor A10 [ Mus musculus (house mouse) ]

Gene ID: 230735, updated on 11-Apr-2024

Summary

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Official Symbol
Epha10provided by MGI
Official Full Name
Eph receptor A10provided by MGI
Primary source
MGI:MGI:3586824
See related
Ensembl:ENSMUSG00000028876 AllianceGenome:MGI:3586824
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A330090H18
Summary
Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within phosphorylation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Is expressed in central nervous system and metanephros. Orthologous to human EPHA10 (EPH receptor A10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 7.2), frontal lobe adult (RPKM 6.4) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 57.92 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124775408..124811594)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (124881530..124917801)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene metal response element binding transcription factor 1 Neighboring gene RIKEN cDNA 1110065P20 gene Neighboring gene yrdC domain containing (E.coli) Neighboring gene mannosidase, endo-alpha-like Neighboring gene RIKEN cDNA 1700125G02 gene Neighboring gene cell division cycle associated 8 Neighboring gene STARR-positive B cell enhancer ABC_E424 Neighboring gene STARR-positive B cell enhancer ABC_E4665 Neighboring gene AFG2 interacting ribosome maturation factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Increased EphA/ephrinA expression in hippocampus of pilocarpine treated mouse. Xia Y, et al. Epilepsy Res, 2013 Jul. PMID 23352741
  2. Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate. Agrawal P, et al. Dev Dyn, 2014 Nov. PMID 25073978, Free PMC Article
  3. EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes. Freywald A, et al. J Immunol, 2006 Apr 1. PMID 16547242
  4. Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis. Aasheim HC, et al. Biochim Biophys Acta, 2005 May 25. PMID 15777695
  5. Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse. Zirzow S, et al. Dev Biol, 2009 Dec 15. PMID 19769959

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ephrin A10 is significantly increased in hippocampus following epileptogenesis.
    Title: Increased EphA/ephrinA expression in hippocampus of pilocarpine treated mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane-ephrin receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ephrin type-A receptor 10
NP_001243361.1
NP_808339.2
XP_006503090.1
XP_006503091.1
XP_017175641.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256432.2 → NP_001243361.1  ephrin type-A receptor 10 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL606933
    UniProtKB/Swiss-Prot
    A2A7J5, Q3UPV5, Q8BYG9
    Conserved Domains (7) summary
    cd09549
    Location:928 → 997
    SAM_EPH-A10; SAM domain of EPH-A10 subfamily of tyrosine kinase receptors
    smart00454
    Location:931 → 996
    SAM; Sterile alpha motif
    cd00063
    Location:451 → 551
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:644 → 899
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:573 → 639
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:35 → 210
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    cl21453
    Location:638 → 902
    PKc_like; Protein Kinases, catalytic domain

  2. NM_177671.6 → NP_808339.2  ephrin type-A receptor 10 isoform 2 precursor

    See identical proteins and their annotated locations for NP_808339.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK143168
    Consensus CDS
    CCDS18630.1
    UniProtKB/Swiss-Prot
    Q8BYG9
    Related
    ENSMUSP00000050810.6, ENSMUST00000059343.7
    Conserved Domains (1) summary
    cl02704
    Location:35 → 210
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    124775408..124811594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503027.3 → XP_006503090.1  ephrin type-A receptor 10 isoform X2

    Conserved Domains (4) summary
    cd00063
    Location:465 → 551
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:339 → 431
    fn3; Fibronectin type III domain
    pfam14575
    Location:573 → 639
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:35 → 210
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors

  2. XM_006503028.5 → XP_006503091.1  ephrin type-A receptor 10 isoform X3

    Conserved Domains (3) summary
    cd00063
    Location:465 → 551
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:339 → 431
    fn3; Fibronectin type III domain
    cl02704
    Location:35 → 210
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors

  3. XM_017320152.3 → XP_017175641.1  ephrin type-A receptor 10 isoform X1

    UniProtKB/TrEMBL
    F6WVB0
    Related
    ENSMUSP00000118801.2, ENSMUST00000149146.2
    Conserved Domains (5) summary
    cd09549
    Location:758 → 827
    SAM_EPH-A10; SAM domain of EPH-A10 subfamily of tyrosine kinase receptors
    cd00063
    Location:281 → 381
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam14575
    Location:403 → 469
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1 → 40
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    cl21453
    Location:468 → 732
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_004941869.1 RNA Sequence

  2. XR_004941871.1 RNA Sequence

  3. XR_004941870.1 RNA Sequence

  4. XR_004941872.1 RNA Sequence

  5. XR_376312.3 RNA Sequence

  6. XR_003954922.2 RNA Sequence

  7. XR_003954923.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BYG9.2 GenPept UniProtKB/Swiss-Prot:Q8BYG9

Gene LinkOut

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