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Yrdc yrdC domain containing (E.coli) [ Mus musculus (house mouse) ]

Gene ID: 230734, updated on 5-Mar-2024

Summary

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Official Symbol
Yrdcprovided by MGI
Official Full Name
yrdC domain containing (E.coli)provided by MGI
Primary source
MGI:MGI:2387201
See related
Ensembl:ENSMUSG00000028889 AllianceGenome:MGI:2387201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IRIP; ITIP
Summary
Predicted to enable nucleotidyltransferase activity and tRNA binding activity. Predicted to be involved in regulation of translational fidelity. Predicted to act upstream of or within negative regulation of transport. Located in membrane. Orthologous to human YRDC (yrdC N6-threonylcarbamoyltransferase domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 33.7), ovary adult (RPKM 30.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 57.92 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124744552..124749035)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (124850759..124855242)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene metal response element binding transcription factor 1 Neighboring gene RIKEN cDNA 1110065P20 gene Neighboring gene predicted gene, 54256 Neighboring gene mannosidase, endo-alpha-like Neighboring gene RIKEN cDNA 1700125G02 gene Neighboring gene Eph receptor A10 Neighboring gene cell division cycle associated 8 Neighboring gene STARR-positive B cell enhancer ABC_E424

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Physical maps of the mouse and human immunoglobulin-like loci. Lai E, et al. Adv Immunol, 1989. PMID 2675563
  2. IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity. Jiang W, et al. Mol Cell Biol, 2005 Aug. PMID 16024787, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC38336

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-threonylcarbamoyladenylate synthase ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of translational fidelity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA threonylcarbamoyladenosine modification ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
threonylcarbamoyl-AMP synthase
Names
Ischemia/reperfusion-inducible protein
mIRIP
yrdC domain-containing protein, mitochondrial
NP_705794.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153566.2 → NP_705794.2  threonylcarbamoyl-AMP synthase precursor

    See identical proteins and their annotated locations for NP_705794.2

    Status: VALIDATED

    Source sequence(s)
    AI413772, AK153627
    Consensus CDS
    CCDS18628.2
    UniProtKB/Swiss-Prot
    B1ARW9, B1ARX2, Q3U5F4, Q7TSY0, Q8CII1
    Related
    ENSMUSP00000099688.5, ENSMUST00000102628.11
    Conserved Domains (1) summary
    COG0009
    Location:70 → 257
    SUA5; tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    124744552..124749035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U5F4.1 GenPept UniProtKB/Swiss-Prot:Q3U5F4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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