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Pars2 prolyl-tRNA synthetase (mitochondrial)(putative) [ Mus musculus (house mouse) ]

Gene ID: 230577, updated on 11-Apr-2024

Summary

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Official Symbol
Pars2provided by MGI
Official Full Name
prolyl-tRNA synthetase (mitochondrial)(putative)provided by MGI
Primary source
MGI:MGI:2386296
See related
Ensembl:ENSMUSG00000043572 AllianceGenome:MGI:2386296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in adrenal gland and gland. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 75. Orthologous to human PARS2 (prolyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 2.6), ovary adult (RPKM 2.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 C7; 4 49.67 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (106508266..106512479)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (106651069..106655282)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ciliary microtubule associated protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:106287642-106287893 Neighboring gene STARR-positive B cell enhancer ABC_E10244 Neighboring gene tetratricopeptide repeat domain 22 Neighboring gene STARR-positive B cell enhancer ABC_E2700 Neighboring gene tetratricopeptide repeat domain 4 Neighboring gene STARR-positive B cell enhancer ABC_E6195 Neighboring gene maestro heat-like repeat family member 7 Neighboring gene family with sequence simliarity 151, member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC47008

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables proline-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in prolyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable proline--tRNA ligase, mitochondrial
Names
class II tRNA synthetase
proRS
probable prolyl-tRNA synthetase, mitochondrial
proline--tRNA ligase
NP_001077356.1
NP_001272712.1
NP_001272713.1
NP_758476.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083887.2 → NP_001077356.1  probable proline--tRNA ligase, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001077356.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AL929585
    Consensus CDS
    CCDS38828.1
    UniProtKB/TrEMBL
    A8Y5T6, Q3U4M2
    Related
    ENSMUSP00000102393.2, ENSMUST00000106781.2
    Conserved Domains (3) summary
    PRK09194
    Location:78 → 506
    PRK09194; prolyl-tRNA synthetase; Provisional
    cd00779
    Location:101 → 390
    ProRS_core_prok; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
    cd00861
    Location:405 → 506
    ProRS_anticodon_short; ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, ...

  2. NM_001285783.1 → NP_001272712.1  probable proline--tRNA ligase, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001272712.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AL929585, BB652093
    Consensus CDS
    CCDS38828.1
    UniProtKB/TrEMBL
    A8Y5T6, Q3U4M2
    Conserved Domains (3) summary
    PRK09194
    Location:78 → 506
    PRK09194; prolyl-tRNA synthetase; Provisional
    cd00779
    Location:101 → 390
    ProRS_core_prok; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
    cd00861
    Location:405 → 506
    ProRS_anticodon_short; ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, ...

  3. NM_001285784.1 → NP_001272713.1  probable proline--tRNA ligase, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001272713.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1 and 4 encode the same isoform (1), which is shorter at the N-terminus compared to isoform 2.
    Source sequence(s)
    AL929585, BB842735
    Consensus CDS
    CCDS18423.1
    UniProtKB/Swiss-Prot
    A2AVQ8, Q8CFI5, Q8R0C4
    UniProtKB/TrEMBL
    Q3U4M2
    Conserved Domains (3) summary
    PRK09194
    Location:42 → 470
    PRK09194; prolyl-tRNA synthetase; Provisional
    cd00779
    Location:65 → 354
    ProRS_core_prok; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
    cd00861
    Location:369 → 470
    ProRS_anticodon_short; ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, ...

  4. NM_172272.2 → NP_758476.2  probable proline--tRNA ligase, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_758476.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1 and 4 encode the same isoform (1), which is shorter at the N-terminus compared to isoform 2.
    Source sequence(s)
    AL929585, BY768753
    Consensus CDS
    CCDS18423.1
    UniProtKB/Swiss-Prot
    A2AVQ8, Q8CFI5, Q8R0C4
    UniProtKB/TrEMBL
    Q3U4M2
    Related
    ENSMUSP00000053160.8, ENSMUST00000058905.8
    Conserved Domains (3) summary
    PRK09194
    Location:42 → 470
    PRK09194; prolyl-tRNA synthetase; Provisional
    cd00779
    Location:65 → 354
    ProRS_core_prok; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
    cd00861
    Location:369 → 470
    ProRS_anticodon_short; ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    106508266..106512479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CFI5.2 GenPept UniProtKB/Swiss-Prot:Q8CFI5

Gene LinkOut

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