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ZSWIM8 zinc finger SWIM-type containing 8 [ Homo sapiens (human) ]

Gene ID: 23053, updated on 11-Apr-2024

Summary

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Official Symbol
ZSWIM8provided by HGNC
Official Full Name
zinc finger SWIM-type containing 8provided by HGNC
Primary source
HGNC:HGNC:23528
See related
Ensembl:ENSG00000214655 MIM:619213; AllianceGenome:HGNC:23528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA0913
Summary
Enables ubiquitin ligase-substrate adaptor activity. Involved in positive regulation of miRNA catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 21.6), spleen (RPKM 16.0) and 25 other tissues See more
Orthologs
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Genomic context

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See ZSWIM8 in Genome Data Viewer
Location:
10q22.2
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73785606..73801793)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74657006..74673193)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75545364..75561551)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3575 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:75543706-75543880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2488 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75548316-75549515 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1 Neighboring gene NDST2-ZSWIM8-AS1 readthrough Neighboring gene ZSWIM8 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2489 Neighboring gene N-deacetylase and N-sulfotransferase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2490 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:75574449-75574702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75579102-75579602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75579603-75580103 Neighboring gene calcium/calmodulin dependent protein kinase II gamma Neighboring gene MPRA-validated peak1013 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75617818-75618318 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75618319-75618819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2493

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming. Han J, et al. Science, 2020 Dec 18. PMID 33184234, Free PMC Article
  2. ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation. Okumura F, et al. Sci Rep, 2021 Oct 22. PMID 34686700, Free PMC Article
  3. A transcript finishing initiative for closing gaps in the human transcriptome. Sogayar MC, et al. Genome Res, 2004 Jul. PMID 15197164, Free PMC Article
  4. The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation. Shi CY, et al. Science, 2020 Dec 18. PMID 33184237, Free PMC Article
  5. The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization. Molina-Pelayo C, et al. Life Sci Alliance, 2022 Aug 8. PMID 35940847, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization.
    Title: The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization.
  2. ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation.
    Title: ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation.
  3. The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation.
    Title: The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation.
  4. A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming.
    Title: A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ34302, KIAA0913, MGC168869, MGC168870, 4832404P21Rik

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of miRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in target-directed miRNA degradation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc finger SWIM domain-containing protein 8
Names
Dorado
Pelado

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242487.2 → NP_001229416.1  zinc finger SWIM domain-containing protein 8 isoform 2

    See identical proteins and their annotated locations for NP_001229416.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AB020720, AC022400, BC040726, BC151206
    Consensus CDS
    CCDS60560.1
    UniProtKB/Swiss-Prot
    A7E2V4, B2RP37, O94987, Q17RS8, Q2TAB8, Q6P439, Q8IW81, Q8NB34, Q9H8F3
    UniProtKB/TrEMBL
    S4R393
    Related
    ENSP00000474748.1, ENST00000605216.5
    Conserved Domains (1) summary
    cl19527
    Location:131 → 263
    SWIM; SWIM zinc finger

  2. NM_001242488.2 → NP_001229417.1  zinc finger SWIM domain-containing protein 8 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in the 3' coding region with the latter resulting in a frameshift, compared to variant 1. It encodes isoform 3, which has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB020720, AC022400, BC040726, BC111006, BC151206
    UniProtKB/TrEMBL
    S4R393
    Conserved Domains (1) summary
    cl19527
    Location:131 → 263
    SWIM; SWIM zinc finger

  3. NM_001367799.1 → NP_001354728.1  zinc finger SWIM domain-containing protein 8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC022400
    Consensus CDS
    CCDS91266.1
    UniProtKB/TrEMBL
    S4R393, S4R410
    Related
    ENSP00000474944.1, ENST00000604729.6

  4. NM_015037.4 → NP_055852.2  zinc finger SWIM domain-containing protein 8 isoform 1

    See identical proteins and their annotated locations for NP_055852.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform (1).
    Source sequence(s)
    AB020720, AC022400, AK023742, BC040726, BC151206
    Consensus CDS
    CCDS44440.1
    UniProtKB/TrEMBL
    S4R393
    Related
    ENSP00000381693.2, ENST00000398706.6
    Conserved Domains (1) summary
    cl19527
    Location:131 → 263
    SWIM; SWIM zinc finger

RNA

  1. NR_160292.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC022400

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    73785606..73801793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269648.3 → XP_005269705.1  zinc finger SWIM domain-containing protein 8 isoform X1

    UniProtKB/TrEMBL
    S4R393
    Conserved Domains (1) summary
    cl19527
    Location:131 → 263
    SWIM; SWIM zinc finger

  2. XM_017015978.2 → XP_016871467.1  zinc finger SWIM domain-containing protein 8 isoform X2

    UniProtKB/TrEMBL
    S4R393

  3. XM_006717725.4 → XP_006717788.1  zinc finger SWIM domain-containing protein 8 isoform X11

    UniProtKB/TrEMBL
    S4R393
    Related
    ENSP00000474043.1, ENST00000603114.5
    Conserved Domains (1) summary
    cl19527
    Location:131 → 263
    SWIM; SWIM zinc finger

  4. XM_047424867.1 → XP_047280823.1  zinc finger SWIM domain-containing protein 8 isoform X10

  5. XM_047424860.1 → XP_047280816.1  zinc finger SWIM domain-containing protein 8 isoform X3

  6. XM_047424868.1 → XP_047280824.1  zinc finger SWIM domain-containing protein 8 isoform X12

  7. XM_047424861.1 → XP_047280817.1  zinc finger SWIM domain-containing protein 8 isoform X4

  8. XM_047424869.1 → XP_047280825.1  zinc finger SWIM domain-containing protein 8 isoform X13

  9. XM_047424870.1 → XP_047280826.1  zinc finger SWIM domain-containing protein 8 isoform X14

  10. XM_047424862.1 → XP_047280818.1  zinc finger SWIM domain-containing protein 8 isoform X5

  11. XM_005269655.4 → XP_005269712.1  zinc finger SWIM domain-containing protein 8 isoform X16

    UniProtKB/TrEMBL
    S4R393
    Conserved Domains (1) summary
    cl19527
    Location:131 → 263
    SWIM; SWIM zinc finger

  12. XM_047424865.1 → XP_047280821.1  zinc finger SWIM domain-containing protein 8 isoform X8

  13. XM_047424871.1 → XP_047280827.1  zinc finger SWIM domain-containing protein 8 isoform X15

  14. XM_047424863.1 → XP_047280819.1  zinc finger SWIM domain-containing protein 8 isoform X6

  15. XM_047424872.1 → XP_047280828.1  zinc finger SWIM domain-containing protein 8 isoform X17

  16. XM_047424866.1 → XP_047280822.1  zinc finger SWIM domain-containing protein 8 isoform X9

  17. XM_047424864.1 → XP_047280820.1  zinc finger SWIM domain-containing protein 8 isoform X7

  18. XM_011539544.2 → XP_011537846.1  zinc finger SWIM domain-containing protein 8 isoform X18

    UniProtKB/TrEMBL
    H7BZ52
    Related
    ENSP00000387828.2, ENST00000433366.6
    Conserved Domains (1) summary
    cl19527
    Location:131 → 263
    SWIM; SWIM zinc finger

  19. XM_047424874.1 → XP_047280830.1  zinc finger SWIM domain-containing protein 8 isoform X19

  20. XM_047424875.1 → XP_047280831.1  zinc finger SWIM domain-containing protein 8 isoform X20

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    74657006..74673193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365274.1 → XP_054221249.1  zinc finger SWIM domain-containing protein 8 isoform X1

  2. XM_054365275.1 → XP_054221250.1  zinc finger SWIM domain-containing protein 8 isoform X2

  3. XM_054365283.1 → XP_054221258.1  zinc finger SWIM domain-containing protein 8 isoform X11

  4. XM_054365282.1 → XP_054221257.1  zinc finger SWIM domain-containing protein 8 isoform X10

  5. XM_054365276.1 → XP_054221251.1  zinc finger SWIM domain-containing protein 8 isoform X3

  6. XM_054365284.1 → XP_054221259.1  zinc finger SWIM domain-containing protein 8 isoform X12

  7. XM_054365277.1 → XP_054221252.1  zinc finger SWIM domain-containing protein 8 isoform X4

  8. XM_054365285.1 → XP_054221260.1  zinc finger SWIM domain-containing protein 8 isoform X13

  9. XM_054365286.1 → XP_054221261.1  zinc finger SWIM domain-containing protein 8 isoform X14

  10. XM_054365278.1 → XP_054221253.1  zinc finger SWIM domain-containing protein 8 isoform X5

  11. XM_054365288.1 → XP_054221263.1  zinc finger SWIM domain-containing protein 8 isoform X16

  12. XM_054365280.1 → XP_054221255.1  zinc finger SWIM domain-containing protein 8 isoform X8

  13. XM_054365287.1 → XP_054221262.1  zinc finger SWIM domain-containing protein 8 isoform X15

  14. XM_054365279.1 → XP_054221254.1  zinc finger SWIM domain-containing protein 8 isoform X6

  15. XM_054365289.1 → XP_054221264.1  zinc finger SWIM domain-containing protein 8 isoform X17

  16. XM_054365281.1 → XP_054221256.1  zinc finger SWIM domain-containing protein 8 isoform X9

  17. XM_054365290.1 → XP_054221265.1  zinc finger SWIM domain-containing protein 8 isoform X18

  18. XM_054365291.1 → XP_054221266.1  zinc finger SWIM domain-containing protein 8 isoform X19

  19. XM_054365292.1 → XP_054221267.1  zinc finger SWIM domain-containing protein 8 isoform X20

  20. XM_054365293.1 → XP_054221268.1  zinc finger SWIM domain-containing protein 8 isoform X21

  21. XM_054365294.1 → XP_054221269.1  zinc finger SWIM domain-containing protein 8 isoform X22

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A7E2V4.1 GenPept UniProtKB/Swiss-Prot:A7E2V4

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