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FNBP1 formin binding protein 1 [ Homo sapiens (human) ]

Gene ID: 23048, updated on 3-Apr-2024

Summary

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Official Symbol
FNBP1provided by HGNC
Official Full Name
formin binding protein 1provided by HGNC
Primary source
HGNC:HGNC:17069
See related
Ensembl:ENSG00000187239 MIM:606191; AllianceGenome:HGNC:17069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBP17
Summary
The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 19.9), spleen (RPKM 17.6) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See FNBP1 in Genome Data Viewer
Location:
9q34.11
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (129887187..130053879, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (142091913..142247931, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (132649466..132805468, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20391 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:132597987-132598487 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132601680-132602180 Neighboring gene chromosome 9 open reading frame 78 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29123 Neighboring gene Sharpr-MPRA regulatory region 12255 Neighboring gene ubiquitin specific peptidase 20 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132632499-132632998 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:132636644-132637144 Neighboring gene Sharpr-MPRA regulatory region 12063 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:132647083-132647764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29125 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:132651249-132652136 Neighboring gene microRNA 6855 Neighboring gene Sharpr-MPRA regulatory region 3297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29128 Neighboring gene Sharpr-MPRA regulatory region 1290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29133 Neighboring gene Sharpr-MPRA regulatory region 9235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29144 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:132786300-132786450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29146 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:132797471-132797971 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:132796970-132797470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20395 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20396 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20397 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132811133-132811633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20398 Neighboring gene G protein-coupled receptor 107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:132878169-132878714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:132881191-132882139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20399 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132904135-132904908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132905683-132906456 Neighboring gene GPR107 adjacent cis regulating lncRNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Membrane tension sensing molecule-FNBP1 is a prognostic biomarker related to immune infiltration in BRCA, LUAD and STAD. Wang Z, et al. BMC Immunol, 2022 Jan 8. PMID 34998385, Free PMC Article
  2. High formin binding protein 17 (FBP17) expression indicates poor differentiation and invasiveness of ductal carcinomas. Suman P, et al. Sci Rep, 2020 Jul 14. PMID 32665637, Free PMC Article
  3. An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation. Echarri A, et al. Nat Commun, 2019 Dec 20. PMID 31862885, Free PMC Article
  4. High expression of FBP17 in invasive breast cancer cells promotes invadopodia formation. Suman P, et al. Med Oncol, 2018 Apr 12. PMID 29651632
  5. Feedback regulation between plasma membrane tension and membrane-bending proteins organizes cell polarity during leading edge formation. Tsujita K, et al. Nat Cell Biol, 2015 Jun. PMID 25938814

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FNBP1 Facilitates Cervical Cancer Cell Survival by the Constitutive Activation of FAK/PI3K/AKT/mTOR Signaling.
    Title: FNBP1 Facilitates Cervical Cancer Cell Survival by the Constitutive Activation of FAK/PI3K/AKT/mTOR Signaling.
  2. Wild-type p53 suppresses formin-binding protein-17 (FBP17) to reduce invasion.
    Title: Wild-type p53 suppresses formin-binding protein-17 (FBP17) to reduce invasion.
  3. Membrane tension sensing molecule-FNBP1 is a prognostic biomarker related to immune infiltration in BRCA, LUAD and STAD.
    Title: Membrane tension sensing molecule-FNBP1 is a prognostic biomarker related to immune infiltration in BRCA, LUAD and STAD.
  4. Sp1-Induced FNBP1 Drives Rigorous 3D Cell Motility in EMT-Type Gastric Cancer Cells.
    Title: Sp1-Induced FNBP1 Drives Rigorous 3D Cell Motility in EMT-Type Gastric Cancer Cells.
  5. High formin binding protein 17 (FBP17) expression indicates poor differentiation and invasiveness of ductal carcinomas.
    Title: High formin binding protein 17 (FBP17) expression indicates poor differentiation and invasiveness of ductal carcinomas.
  6. Study shows that plasma membrane (PM) mechanoadaptation is controlled by a tension-sensing pathway composed of c-Abl tyrosine kinase and membrane curvature regulator FBP17. FBP17 is recruited to caveolae to induce the formation of caveolar rosettes. FBP17 deficient cells have reduced rosette density, lack PM tension buffering capacity under osmotic shock, and cannot adapt to mechanical strain.
    Title: An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation.
  7. FBP17 and CIP4 prime the membrane of resting cells for fast endophilin-mediated endocytosis by recruiting the 5'-lipid phosphatase SHIP2 and lamellipodin to mediate the local production of phosphatidylinositol-3,4-bisphosphate and endophilin pre-enrichment.
    Title: FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis.
  8. Results suggest that FBP17 is highly expressed in breast cancer cells and facilitates the invasion of breast cancer cells.
    Title: High expression of FBP17 in invasive breast cancer cells promotes invadopodia formation.
  9. FBP17 is the local activator of actin polymerization that is inhibited by PM tension in the feedback loop that regulates cell migration.
    Title: Feedback regulation between plasma membrane tension and membrane-bending proteins organizes cell polarity during leading edge formation.
  10. Knockdown of PSTPIP2 inmacrophages enhances the assembly of FBP17, leading to'hyperactivation' of actin nucleation at podosomes and ECM degradation.
    Title: Antagonistic regulation of F-BAR protein assemblies controls actin polymerization during podosome formation.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0554, MGC126804

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
formin-binding protein 1
Names
formin-binding protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033946.2 RefSeqGene

    Range
    15690..171692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001363755.1 → NP_001350684.1  formin-binding protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AA848014, AK023681, AL158207, DA043485
    Consensus CDS
    CCDS87699.1
    UniProtKB/TrEMBL
    A0A994J4A3
    Related
    ENSP00000347907.3, ENST00000355681.3
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:378 → 454
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:524 → 579
    SH3; Src Homology 3 domain superfamily

  2. NM_001411018.1 → NP_001397947.1  formin-binding protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL136141, AL158207
    Consensus CDS
    CCDS94507.1
    UniProtKB/TrEMBL
    A0A994J3U5
    Related
    ENSP00000515359.1, ENST00000703533.1

  3. NM_015033.3 → NP_055848.1  formin-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_055848.1

    Status: REVIEWED

    Source sequence(s)
    AB011126, AL158207, AW575478, CK005680
    Consensus CDS
    CCDS48040.1
    UniProtKB/Swiss-Prot
    B7ZL12, E9PGQ4, O60301, Q3MIN8, Q5TC87, Q5TC88, Q6P658, Q7LGG2, Q96RU3, Q9H8H8, Q9NWD1
    UniProtKB/TrEMBL
    A0A994J4A3
    Related
    ENSP00000413625.1, ENST00000446176.7
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:407 → 483
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:553 → 608
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    129887187..130053879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251834.3 → XP_005251891.1  formin-binding protein 1 isoform X33

    See identical proteins and their annotated locations for XP_005251891.1

    UniProtKB/TrEMBL
    A0A994J4A3, B7ZL14, E7EPB7
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:341 → 417
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:487 → 542
    SH3; Src Homology 3 domain superfamily

  2. XM_047423022.1 → XP_047278978.1  formin-binding protein 1 isoform X32

  3. XM_047423021.1 → XP_047278977.1  formin-binding protein 1 isoform X28

  4. XM_047423020.1 → XP_047278976.1  formin-binding protein 1 isoform X27

    Related
    ENSP00000515374.1, ENST00000703558.1

  5. XM_047423018.1 → XP_047278974.1  formin-binding protein 1 isoform X24

  6. XM_047423017.1 → XP_047278973.1  formin-binding protein 1 isoform X23

  7. XM_005251826.3 → XP_005251883.1  formin-binding protein 1 isoform X20

    See identical proteins and their annotated locations for XP_005251883.1

    UniProtKB/TrEMBL
    A0A994J4A3, B7ZL13
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:397 → 473
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:543 → 598
    SH3; Src Homology 3 domain superfamily

  8. XM_047423014.1 → XP_047278970.1  formin-binding protein 1 isoform X9

  9. XM_005251824.3 → XP_005251881.1  formin-binding protein 1 isoform X17

    See identical proteins and their annotated locations for XP_005251881.1

    UniProtKB/TrEMBL
    A0A994J4A3
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:402 → 478
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:548 → 603
    SH3; Src Homology 3 domain superfamily

  10. XM_047423016.1 → XP_047278972.1  formin-binding protein 1 isoform X16

  11. XM_047423013.1 → XP_047278969.1  formin-binding protein 1 isoform X7

  12. XM_011518402.2 → XP_011516704.1  formin-binding protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8V8TQ35, A0A994J6U4
    Related
    ENSP00000514403.1, ENST00000699492.1
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:435 → 511
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cd12071
    Location:581 → 636
    SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17

  13. XM_011518401.2 → XP_011516703.1  formin-binding protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A994J6U4
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:435 → 511
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cd12071
    Location:582 → 637
    SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17

  14. XM_017014492.3 → XP_016869981.1  formin-binding protein 1 isoform X29

    UniProtKB/TrEMBL
    A0A994J6U4

  15. XM_005251833.4 → XP_005251890.1  formin-binding protein 1 isoform X31

    UniProtKB/TrEMBL
    A0A994J4A3
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:341 → 417
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:487 → 542
    SH3; Src Homology 3 domain superfamily

  16. XM_005251831.4 → XP_005251888.1  formin-binding protein 1 isoform X30

    UniProtKB/TrEMBL
    A0A994J4A3
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:346 → 422
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:493 → 548
    SH3; Src Homology 3 domain superfamily

  17. XM_047423019.1 → XP_047278975.1  formin-binding protein 1 isoform X26

  18. XM_005251830.4 → XP_005251887.1  formin-binding protein 1 isoform X25

    UniProtKB/TrEMBL
    A0A994J4A3
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:373 → 449
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:520 → 575
    SH3; Src Homology 3 domain superfamily

  19. XM_047423015.1 → XP_047278971.1  formin-binding protein 1 isoform X15

  20. XM_006717016.4 → XP_006717079.1  formin-binding protein 1 isoform X12

    UniProtKB/TrEMBL
    A0A994J6U4
    Related
    ENSP00000515376.1, ENST00000703560.1
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:406 → 482
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:553 → 608
    SH3; Src Homology 3 domain superfamily

  21. XM_005251828.4 → XP_005251885.1  formin-binding protein 1 isoform X22

    UniProtKB/TrEMBL
    A0A994J4A3, H0Y7W6
    Related
    ENSP00000415602.3, ENST00000449089.7
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:392 → 468
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:538 → 593
    SH3; Src Homology 3 domain superfamily

  22. XM_005251827.4 → XP_005251884.1  formin-binding protein 1 isoform X21

    UniProtKB/TrEMBL
    A0A994J4A3
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:392 → 468
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:539 → 594
    SH3; Src Homology 3 domain superfamily

  23. XM_005251825.4 → XP_005251882.1  formin-binding protein 1 isoform X19

    UniProtKB/TrEMBL
    A0A994J4A3
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:397 → 473
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:543 → 598
    SH3; Src Homology 3 domain superfamily

  24. XM_017014488.3 → XP_016869977.1  formin-binding protein 1 isoform X18

    UniProtKB/TrEMBL
    A0A994J4A3

  25. XM_005251815.4 → XP_005251872.1  formin-binding protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A994J6U4
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:425 → 501
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:572 → 627
    SH3; Src Homology 3 domain superfamily

  26. XM_005251823.4 → XP_005251880.1  formin-binding protein 1 isoform X14

    UniProtKB/TrEMBL
    A0A994J4A3
    Related
    ENSP00000515358.1, ENST00000703532.1
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:402 → 478
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:548 → 603
    SH3; Src Homology 3 domain superfamily

  27. XM_005251822.4 → XP_005251879.1  formin-binding protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A994J4A3
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:402 → 478
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:549 → 604
    SH3; Src Homology 3 domain superfamily

  28. XM_005251821.4 → XP_005251878.1  formin-binding protein 1 isoform X11

    UniProtKB/TrEMBL
    A0A994J4A3
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:407 → 483
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:553 → 608
    SH3; Src Homology 3 domain superfamily

  29. XM_005251820.4 → XP_005251877.1  formin-binding protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A994J3V8, A0A994J4A3
    Related
    ENSP00000515375.1, ENST00000703559.1
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:407 → 483
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:554 → 609
    SH3; Src Homology 3 domain superfamily

  30. XM_047423012.1 → XP_047278968.1  formin-binding protein 1 isoform X6

  31. XM_047423011.1 → XP_047278967.1  formin-binding protein 1 isoform X4

  32. XM_011518400.4 → XP_011516702.1  formin-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A994J6U4
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:435 → 511
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cd12071
    Location:581 → 636
    SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17

  33. XM_011518399.4 → XP_011516701.1  formin-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A994J6U4
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:435 → 511
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cd12071
    Location:582 → 637
    SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    142091913..142247931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362428.1 → XP_054218403.1  formin-binding protein 1 isoform X33

  2. XM_054362427.1 → XP_054218402.1  formin-binding protein 1 isoform X32

  3. XM_054362424.1 → XP_054218399.1  formin-binding protein 1 isoform X28

  4. XM_054362423.1 → XP_054218398.1  formin-binding protein 1 isoform X27

  5. XM_054362420.1 → XP_054218395.1  formin-binding protein 1 isoform X24

  6. XM_054362419.1 → XP_054218394.1  formin-binding protein 1 isoform X23

  7. XM_054362416.1 → XP_054218391.1  formin-binding protein 1 isoform X20

  8. XM_054362405.1 → XP_054218380.1  formin-binding protein 1 isoform X9

  9. XM_054362413.1 → XP_054218388.1  formin-binding protein 1 isoform X17

  10. XM_054362412.1 → XP_054218387.1  formin-binding protein 1 isoform X16

  11. XM_054362403.1 → XP_054218378.1  formin-binding protein 1 isoform X7

  12. XM_054362401.1 → XP_054218376.1  formin-binding protein 1 isoform X5

  13. XM_054362399.1 → XP_054218374.1  formin-binding protein 1 isoform X3

  14. XM_054362426.1 → XP_054218401.1  formin-binding protein 1 isoform X31

  15. XM_054362425.1 → XP_054218400.1  formin-binding protein 1 isoform X30

  16. XM_054362422.1 → XP_054218397.1  formin-binding protein 1 isoform X26

  17. XM_054362421.1 → XP_054218396.1  formin-binding protein 1 isoform X25

  18. XM_054362411.1 → XP_054218386.1  formin-binding protein 1 isoform X15

  19. XM_054362408.1 → XP_054218383.1  formin-binding protein 1 isoform X12

  20. XM_054362418.1 → XP_054218393.1  formin-binding protein 1 isoform X22

  21. XM_054362417.1 → XP_054218392.1  formin-binding protein 1 isoform X21

  22. XM_054362415.1 → XP_054218390.1  formin-binding protein 1 isoform X19

  23. XM_054362414.1 → XP_054218389.1  formin-binding protein 1 isoform X18

  24. XM_054362404.1 → XP_054218379.1  formin-binding protein 1 isoform X8

  25. XM_054362410.1 → XP_054218385.1  formin-binding protein 1 isoform X14

  26. XM_054362409.1 → XP_054218384.1  formin-binding protein 1 isoform X13

  27. XM_054362407.1 → XP_054218382.1  formin-binding protein 1 isoform X11

  28. XM_054362406.1 → XP_054218381.1  formin-binding protein 1 isoform X10

  29. XM_054362402.1 → XP_054218377.1  formin-binding protein 1 isoform X6

  30. XM_054362400.1 → XP_054218375.1  formin-binding protein 1 isoform X4

  31. XM_054362398.1 → XP_054218373.1  formin-binding protein 1 isoform X2

  32. XM_054362397.1 → XP_054218372.1  formin-binding protein 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96RU3.2 GenPept UniProtKB/Swiss-Prot:Q96RU3

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