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Haus6 HAUS augmin-like complex, subunit 6 [ Mus musculus (house mouse) ]

Gene ID: 230376, updated on 25-Apr-2024

Summary

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Official Symbol
Haus6provided by MGI
Official Full Name
HAUS augmin-like complex, subunit 6provided by MGI
Primary source
MGI:MGI:1923389
See related
Ensembl:ENSMUSG00000038047 AllianceGenome:MGI:1923389
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D4Ertd27e; mKIAA1574; 9830144E06; 6230416J20Rik
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in centrosome cycle and spindle assembly. Predicted to be located in centriolar satellite; cytosol; and nuclear speck. Predicted to be part of HAUS complex. Predicted to be active in mitotic spindle microtubule. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human HAUS6 (HAUS augmin like complex subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 5.7), liver E14 (RPKM 3.9) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 C4; 4 40.69 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (86497092..86530317, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (86578855..86612075, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene stabilizer of axonemal microtubules 1, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E4635 Neighboring gene STARR-positive B cell enhancer mm9_chr4:86225970-86226270 Neighboring gene Ras-related GTP binding A Neighboring gene small Cajal body-specific RNA 8 Neighboring gene STARR-positive B cell enhancer ABC_E2115 Neighboring gene STARR-seq mESC enhancer starr_10694 Neighboring gene perilipin 2 pseudogene Neighboring gene perilipin 2 Neighboring gene STARR-seq mESC enhancer starr_10695 Neighboring gene STARR-seq mESC enhancer starr_10697 Neighboring gene STARR-seq mESC enhancer starr_10698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:86358735-86358844 Neighboring gene predicted gene, 42312

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold. Schweizer N, et al. Nat Commun, 2021 Oct 15. PMID 34654813, Free PMC Article
  2. Intra-spindle Microtubule Assembly Regulates Clustering of Microtubule-Organizing Centers during Early Mouse Development. Watanabe S, et al. Cell Rep, 2016 Apr 5. PMID 27052165
  3. Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development. Viais R, et al. Elife, 2021 Aug 24. PMID 34427181, Free PMC Article
  4. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
  5. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development.
    Title: Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development.
  2. Augmin is essential for embryonic cell division. Microtubule-organizing center clustering during the blastocyst stage requires augmin.
    Title: Intra-spindle Microtubule Assembly Regulates Clustering of Microtubule-Organizing Centers during Early Mouse Development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of HAUS complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
HAUS augmin-like complex subunit 6
Names
likely ortholog of H. sapiens family with sequence similarity 29, member A (FAM29A)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173400.3 → NP_775576.2  HAUS augmin-like complex subunit 6

    See identical proteins and their annotated locations for NP_775576.2

    Status: VALIDATED

    Source sequence(s)
    AL824707, BB851382, BC068237, BX516644, BY471626
    Consensus CDS
    CCDS18307.1
    UniProtKB/TrEMBL
    Q69ZG0, Q6NV99
    Related
    ENSMUSP00000070504.8, ENSMUST00000070607.9
    Conserved Domains (1) summary
    pfam14661
    Location:15 → 238
    HAUS6_N; HAUS augmin-like complex subunit 6 N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    86497092..86530317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537875.4 → XP_006537938.1  HAUS augmin-like complex subunit 6 isoform X1

    UniProtKB/TrEMBL
    Q69ZG0
    Conserved Domains (1) summary
    pfam14661
    Location:17 → 238
    HAUS6_N; HAUS augmin-like complex subunit 6 N-terminus

  2. XM_036163993.1 → XP_036019886.1  HAUS augmin-like complex subunit 6 isoform X3

    UniProtKB/TrEMBL
    Q6P252
    Conserved Domains (1) summary
    pfam14661
    Location:8 → 99
    HAUS6_N; HAUS augmin-like complex subunit 6 N-terminus

  3. XM_011250010.4 → XP_011248312.1  HAUS augmin-like complex subunit 6 isoform X2

    See identical proteins and their annotated locations for XP_011248312.1

    UniProtKB/TrEMBL
    Q6P252
    Conserved Domains (1) summary
    pfam14661
    Location:8 → 99
    HAUS6_N; HAUS augmin-like complex subunit 6 N-terminus

  4. XM_011250011.2 → XP_011248313.1  HAUS augmin-like complex subunit 6 isoform X2

    See identical proteins and their annotated locations for XP_011248313.1

    UniProtKB/TrEMBL
    Q6P252
    Conserved Domains (1) summary
    pfam14661
    Location:8 → 99
    HAUS6_N; HAUS augmin-like complex subunit 6 N-terminus
Nucleotide Protein Strain
Heading Accession and Version

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