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MYO16 myosin XVI [ Homo sapiens (human) ]

Gene ID: 23026, updated on 11-Apr-2024

Summary

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Official Symbol
MYO16provided by HGNC
Official Full Name
myosin XVIprovided by HGNC
Primary source
HGNC:HGNC:29822
See related
Ensembl:ENSG00000041515 MIM:615479; AllianceGenome:HGNC:29822
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYR8; MYAP3; NYAP3; Myo16b; PPP1R107
Summary
This gene encodes an unconventional myosin protein. The encoded protein has been proposed to act as a serine/threonine phosphatase-1 targeting or regulatory subunit. Studies in a rat cell line suggest that this protein may regulate cell cycle progression. A variant within this gene may be associated with susceptibility to schizophrenia and elevated expression of this gene has been observed in the frontal cortex of human schizophrenia patients. [provided by RefSeq, Mar 2017]
Expression
Biased expression in brain (RPKM 1.6), fat (RPKM 1.1) and 8 other tissues See more
Orthologs
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Genomic context

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See MYO16 in Genome Data Viewer
Location:
13q33.3
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (108495716..109208005)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (107723546..108435400)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (109248253..109860353)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370355 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32209 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32236 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32244 Neighboring gene Sharpr-MPRA regulatory region 13714 Neighboring gene host cell factor C2 pseudogene 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32288 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32298 Neighboring gene NANOG hESC enhancer GRCh37_chr13:109270467-109270968 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:109304354-109304547 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32357 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:109487341-109487872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7989 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32390 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:109643265-109644464 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:109663206-109663857 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr13:109752798-109753997 Neighboring gene MYO16 antisense RNA 2 Neighboring gene uncharacterized LOC124903208 Neighboring gene uncharacterized LOC105370356 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:109807999-109809198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:109811697-109812202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:109812203-109812708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5497 Neighboring gene uncharacterized LOC124903207 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:109841281-109841780 Neighboring gene MYO16 antisense RNA 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr13:109863465-109864664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:109919619-109920577 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:109923095-109923823 Neighboring gene uncharacterized LOC130494219 Neighboring gene long intergenic non-protein coding RNA 3061

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Fine mapping on chromosome 13q32-34 and brain expression analysis implicates MYO16 in schizophrenia. Rodriguez-Murillo L, et al. Neuropsychopharmacology, 2014 Mar. PMID 24141571, Free PMC Article
  2. Myosin16b: The COOH-tail region directs localization to the nucleus and overexpression delays S-phase progression. Cameron RS, et al. Cell Motil Cytoskeleton, 2007 Jan. PMID 17029291
  3. Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus. Suetsugu H, et al. Hum Mol Genet, 2022 Mar 31. PMID 34850884, Free PMC Article
  4. Genome-wide linkage and association scans for pulse pressure in Chinese twins. Zhang D, et al. Hypertens Res, 2012 Nov. PMID 22763476
  5. Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1. Patel KG, et al. J Neurosci, 2001 Oct 15. PMID 11588169, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus.
    Title: Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus.
  2. KIRREL3 interacting proteins MAP1B and MYO16 are potential candidates for intellectual disability and autism spectrum disorder.
    Title: Autism and Intellectual Disability-Associated KIRREL3 Interacts with Neuronal Proteins MAP1B and MYO16 with Potential Roles in Neurodevelopment.
  3. This study suggest that common variation within MYO16 may contribute to the genetic liability to schizophrenia.
    Title: Fine mapping on chromosome 13q32-34 and brain expression analysis implicates MYO16 in schizophrenia.
  4. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  7. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Human variation in alcohol response is influenced by variation in neuronal signaling genes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Gene network analysis in a pediatric cohort identifies novel lung function genes.
EBI GWAS Catalog
Genome-wide association study of antiphospholipid antibodies.
EBI GWAS Catalog
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
EBI GWAS Catalog
Genome-wide linkage and association scans for pulse pressure in Chinese twins.
EBI GWAS Catalog
GWAS of dental caries patterns in the permanent dentition.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0865

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cerebellum development ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of myosin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
unconventional myosin-XVI
Names
MYO16 variant protein
myosin heavy chain Myr 8
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 3
protein phosphatase 1, regulatory subunit 107
unconventional myosin-16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053147.2 RefSeqGene

    Range
    138897..717291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198950.3 → NP_001185879.1  unconventional myosin-XVI isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL136132, AL157771, AL161431, AL353143, AL390918
    Consensus CDS
    CCDS73598.1
    UniProtKB/TrEMBL
    F8W883
    Related
    ENSP00000401633.3, ENST00000457511.7
    Conserved Domains (6) summary
    smart00242
    Location:426 → 1165
    MYSc; Myosin. Large ATPases
    COG0666
    Location:81 → 332
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:142 → 297
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14878
    Location:437 → 1155
    MYSc_Myo16; class XVI myosin, motor domain
    pfam15439
    Location:1253 → 1590
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    sd00045
    Location:243 → 274
    ANK; ANK repeat [structural motif]

  2. NM_015011.3 → NP_055826.1  unconventional myosin-XVI isoform 2

    See identical proteins and their annotated locations for NP_055826.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL136132, AL157771, AL161431, AL353143, AL390918, AL512648
    Consensus CDS
    CCDS32008.1
    UniProtKB/Swiss-Prot
    A6H8Y0, A8MTX3, Q5VYX4, Q5VYX5, Q5VYX6, Q6ZS13, Q8N3C2, Q8N948, Q9Y6X6
    Related
    ENSP00000349145.2, ENST00000356711.7
    Conserved Domains (6) summary
    smart00242
    Location:404 → 1143
    MYSc; Myosin. Large ATPases
    COG0666
    Location:59 → 310
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:120 → 275
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14878
    Location:415 → 1133
    MYSc_Myo16; class XVI myosin, motor domain
    pfam15439
    Location:1231 → 1568
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    sd00045
    Location:221 → 252
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    108495716..109208005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521062.2 → XP_011519364.1  unconventional myosin-XVI isoform X2

    See identical proteins and their annotated locations for XP_011519364.1

    UniProtKB/Swiss-Prot
    A6H8Y0, A8MTX3, Q5VYX4, Q5VYX5, Q5VYX6, Q6ZS13, Q8N3C2, Q8N948, Q9Y6X6
    Conserved Domains (6) summary
    smart00242
    Location:404 → 1143
    MYSc; Myosin. Large ATPases
    COG0666
    Location:59 → 310
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:120 → 275
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14878
    Location:415 → 1133
    MYSc_Myo16; class XVI myosin, motor domain
    pfam15439
    Location:1231 → 1568
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    sd00045
    Location:221 → 252
    ANK; ANK repeat [structural motif]

  2. XM_047430183.1 → XP_047286139.1  unconventional myosin-XVI isoform X3

  3. XM_047430182.1 → XP_047286138.1  unconventional myosin-XVI isoform X1

  4. XM_047430184.1 → XP_047286140.1  unconventional myosin-XVI isoform X4

  5. XM_047430185.1 → XP_047286141.1  unconventional myosin-XVI isoform X5

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_013171811.1 Reference GRCh38.p14 PATCHES

    Range
    25478..116873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    107723546..108435400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374267.1 → XP_054230242.1  unconventional myosin-XVI isoform X2

  2. XM_054374268.1 → XP_054230243.1  unconventional myosin-XVI isoform X3

  3. XM_054374266.1 → XP_054230241.1  unconventional myosin-XVI isoform X1

  4. XM_054374269.1 → XP_054230244.1  unconventional myosin-XVI isoform X4

  5. XM_054374270.1 → XP_054230245.1  unconventional myosin-XVI isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6X6.3 GenPept UniProtKB/Swiss-Prot:Q9Y6X6

Gene LinkOut

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