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E130308A19Rik RIKEN cDNA E130308A19 gene [ Mus musculus (house mouse) ]

Gene ID: 230259, updated on 5-Mar-2024

Summary

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Official Symbol
E130308A19Rikprovided by MGI
Official Full Name
RIKEN cDNA E130308A19 geneprovided by MGI
Primary source
MGI:MGI:2442164
See related
Ensembl:ENSMUSG00000045071 AllianceGenome:MGI:2442164
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Is expressed in neural retina. Orthologous to human KIAA1958 (KIAA1958). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 1.9), whole brain E14.5 (RPKM 1.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 B3; 4 32.73 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (59626116..59757649)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (59626116..59757649)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene polypyrimidine tract binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_10379 Neighboring gene STARR-positive B cell enhancer ABC_E4631 Neighboring gene STARR-positive B cell enhancer ABC_E6183 Neighboring gene STARR-positive B cell enhancer ABC_E835 Neighboring gene STARR-seq mESC enhancer starr_10381 Neighboring gene hydroxysteroid dehydrogenase like 2 Neighboring gene predicted gene, 54283 Neighboring gene STARR-seq mESC enhancer starr_10382 Neighboring gene STARR-positive B cell enhancer ABC_E421 Neighboring gene STARR-seq mESC enhancer starr_10383 Neighboring gene STARR-positive B cell enhancer ABC_E7970 Neighboring gene STARR-positive B cell enhancer ABC_E3493 Neighboring gene INTS3 and NABP interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E6184 Neighboring gene STARR-positive B cell enhancer ABC_E9590 Neighboring gene STARR-positive B cell enhancer ABC_E10237 Neighboring gene sorting nexin family member 30 Neighboring gene sorting nexin 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC47072

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  

General protein information

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Preferred Names
uncharacterized protein KIAA1958 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015681.2 → NP_001015681.1  uncharacterized protein KIAA1958 homolog isoform 2

    See identical proteins and their annotated locations for NP_001015681.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longer isoform (2).
    Source sequence(s)
    AK047478, AK081604
    Consensus CDS
    CCDS18223.1
    UniProtKB/Swiss-Prot
    B1AX79, Q8BN62, Q8C4P0, Q8K1X8
    UniProtKB/TrEMBL
    Q0P6E2
    Related
    ENSMUSP00000065702.5, ENSMUST00000070150.11
    Conserved Domains (1) summary
    pfam12012
    Location:532 → 686
    DUF3504; Domain of unknown function (DUF3504)

  2. NM_153158.5 → NP_694798.1  uncharacterized protein KIAA1958 homolog isoform 1

    See identical proteins and their annotated locations for NP_694798.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains an alternate 3' terminal exon compared to variant 2. It encodes isoform 1, which is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AK047478, AK047601, AL806512
    Consensus CDS
    CCDS18224.1
    UniProtKB/Swiss-Prot
    Q8C4P0
    Related
    ENSMUSP00000062493.7, ENSMUST00000052420.7
    Conserved Domains (2) summary
    COG3456
    Location:255 → 411
    COG3456; Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport]
    cl00213
    Location:523 → 669
    DNA_BRE_C; DNA breaking-rejoining enzymes, C-terminal catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    59626116..59757649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537855.4 → XP_006537918.1  uncharacterized protein KIAA1958 homolog isoform X1

    See identical proteins and their annotated locations for XP_006537918.1

    Conserved Domains (2) summary
    pfam12012
    Location:577 → 725
    DUF3504; Domain of unknown function (DUF3504)
    pfam17823
    Location:226 → 386
    DUF5585; Family of unknown function (DUF5585)

  2. XM_006537861.3 → XP_006537924.1  uncharacterized protein KIAA1958 homolog isoform X2

    See identical proteins and their annotated locations for XP_006537924.1

    UniProtKB/Swiss-Prot
    Q8C4P0
    Conserved Domains (2) summary
    COG3456
    Location:255 → 411
    COG3456; Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport]
    cl00213
    Location:523 → 669
    DNA_BRE_C; DNA breaking-rejoining enzymes, C-terminal catalytic domain

  3. XM_006537864.4 → XP_006537927.1  uncharacterized protein KIAA1958 homolog isoform X3

    Conserved Domains (1) summary
    COG3456
    Location:255 → 387
    COG3456; Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport]

  4. XM_011250008.4 → XP_011248310.1  uncharacterized protein KIAA1958 homolog isoform X1

    See identical proteins and their annotated locations for XP_011248310.1

    Conserved Domains (2) summary
    pfam12012
    Location:577 → 725
    DUF3504; Domain of unknown function (DUF3504)
    pfam17823
    Location:226 → 386
    DUF5585; Family of unknown function (DUF5585)

  5. XM_036163991.1 → XP_036019884.1  uncharacterized protein KIAA1958 homolog isoform X2

    Conserved Domains (2) summary
    COG3456
    Location:255 → 411
    COG3456; Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport]
    cl00213
    Location:523 → 669
    DNA_BRE_C; DNA breaking-rejoining enzymes, C-terminal catalytic domain

  6. XM_006537858.3 → XP_006537921.1  uncharacterized protein KIAA1958 homolog isoform X1

    See identical proteins and their annotated locations for XP_006537921.1

    Conserved Domains (2) summary
    pfam12012
    Location:577 → 725
    DUF3504; Domain of unknown function (DUF3504)
    pfam17823
    Location:226 → 386
    DUF5585; Family of unknown function (DUF5585)

RNA

  1. XR_004941861.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C4P0.1 GenPept UniProtKB/Swiss-Prot:Q8C4P0

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