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Zfp189 zinc finger protein 189 [ Mus musculus (house mouse) ]

Gene ID: 230162, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp189provided by MGI
Official Full Name
zinc finger protein 189provided by MGI
Primary source
MGI:MGI:2444707
See related
Ensembl:ENSMUSG00000039634 AllianceGenome:MGI:2444707
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C430015I23Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain and eye. Orthologous to human ZNF189 (zinc finger protein 189). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 2.7), CNS E14 (RPKM 2.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp189 in Genome Data Viewer
Location:
4 B1; 4 26.55 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (49521176..49531558)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (49521176..49531558)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52736 Neighboring gene mitochondrial ribosomal protein L50 Neighboring gene aldolase B, fructose-bisphosphate Neighboring gene post-GPI attachment to proteins GalNAc transferase 4 Neighboring gene predicted gene, 33106

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zinc finger protein 189 promotes the differentiation of lamina propria T helper 17.1 cells in dextran sulfate sodium-induced colitis. Xia Z, et al. Autoimmunity, 2023 Dec. PMID 36942486
  2. CREB Binding at the Zfp189 Promoter Within Medium Spiny Neuron Subtypes Differentially Regulates Behavioral and Physiological Adaptations Over the Course of Cocaine Use. Teague CD, et al. Biol Psychiatry, 2023 Mar 15. PMID 36253194, Free PMC Article
  3. Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex. Lorsch ZS, et al. Nat Neurosci, 2019 Sep. PMID 31427770, Free PMC Article
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zinc finger protein 189 promotes the differentiation of lamina propria T helper 17.1 cells in dextran sulfate sodium-induced colitis.
    Title: Zinc finger protein 189 promotes the differentiation of lamina propria T helper 17.1 cells in dextran sulfate sodium-induced colitis.
  2. CREB Binding at the Zfp189 Promoter Within Medium Spiny Neuron Subtypes Differentially Regulates Behavioral and Physiological Adaptations Over the Course of Cocaine Use.
    Title: CREB Binding at the Zfp189 Promoter Within Medium Spiny Neuron Subtypes Differentially Regulates Behavioral and Physiological Adaptations Over the Course of Cocaine Use.
  3. Zfp189 in prefrontal cortical neurons...promotes behavioral resilience
    Title: Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 189

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289901.1 → NP_001276830.1  zinc finger protein 189

    See identical proteins and their annotated locations for NP_001276830.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK049475, AK051265, BY085925, BY420591
    Consensus CDS
    CCDS18175.1
    UniProtKB/TrEMBL
    Q8BKP2
    Related
    ENSMUSP00000036663.7, ENSMUST00000042964.13
    Conserved Domains (4) summary
    cd07765
    Location:12 → 39
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:116 → 506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:328 → 348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:368 → 393
    zf-H2C2_2; Zinc-finger double domain

  2. NM_145547.3 → NP_663522.2  zinc finger protein 189

    See identical proteins and their annotated locations for NP_663522.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK049475, AK051265, BY085925, BY420591
    Consensus CDS
    CCDS18175.1
    UniProtKB/TrEMBL
    Q8BKP2
    Related
    ENSMUSP00000103324.2, ENSMUST00000107696.2
    Conserved Domains (4) summary
    cd07765
    Location:12 → 39
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:116 → 506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:328 → 348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:368 → 393
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    49521176..49531558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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