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Zbtb5 zinc finger and BTB domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 230119, updated on 5-Mar-2024

Summary

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Official Symbol
Zbtb5provided by MGI
Official Full Name
zinc finger and BTB domain containing 5provided by MGI
Primary source
MGI:MGI:1924601
See related
Ensembl:ENSMUSG00000049657 AllianceGenome:MGI:1924601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0354; 5930421I10; 9430083K24Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and skin. Orthologous to human ZBTB5 (zinc finger and BTB domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 8.9), whole brain E14.5 (RPKM 8.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 B1; 4 23.66 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (44991242..45012412, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (44991242..45012412, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8808 Neighboring gene STARR-positive B cell enhancer ABC_E2110 Neighboring gene predicted gene 12679 Neighboring gene STARR-positive B cell enhancer ABC_E6170 Neighboring gene glyoxylate reductase/hydroxypyruvate reductase Neighboring gene RIKEN cDNA 1700055D18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45025246-45025433 Neighboring gene STARR-positive B cell enhancer ABC_E71 Neighboring gene STARR-seq mESC enhancer starr_10090 Neighboring gene polymerase (RNA) I polypeptide E Neighboring gene F-box protein 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Clone Names

  • KIAA0354

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 5
Names
expressed in brain and neural tube
transcription factor ZNF-POZ

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163283.1 → NP_001156755.1  zinc finger and BTB domain-containing protein 5

    See identical proteins and their annotated locations for NP_001156755.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    BC054551, BC057545, CN665638
    Consensus CDS
    CCDS18129.1
    UniProtKB/Swiss-Prot
    Q3TVR7, Q6GV09, Q7TQG0, Q8BIB5
    Related
    ENSMUSP00000136507.2, ENSMUST00000180217.2
    Conserved Domains (4) summary
    smart00225
    Location:25 → 119
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:608 → 628
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:14 → 119
    BTB; BTB/POZ domain
    pfam13465
    Location:620 → 645
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001163284.1 → NP_001156756.1  zinc finger and BTB domain-containing protein 5

    See identical proteins and their annotated locations for NP_001156756.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    BC054551, BC057545
    Consensus CDS
    CCDS18129.1
    UniProtKB/Swiss-Prot
    Q3TVR7, Q6GV09, Q7TQG0, Q8BIB5
    Related
    ENSMUSP00000103447.3, ENSMUST00000107817.3
    Conserved Domains (4) summary
    smart00225
    Location:25 → 119
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:608 → 628
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:14 → 119
    BTB; BTB/POZ domain
    pfam13465
    Location:620 → 645
    zf-H2C2_2; Zinc-finger double domain

  3. NM_173399.3 → NP_775575.2  zinc finger and BTB domain-containing protein 5

    See identical proteins and their annotated locations for NP_775575.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    BC054551, BC057545
    Consensus CDS
    CCDS18129.1
    UniProtKB/Swiss-Prot
    Q3TVR7, Q6GV09, Q7TQG0, Q8BIB5
    Related
    ENSMUSP00000059919.9, ENSMUST00000055028.9
    Conserved Domains (4) summary
    smart00225
    Location:25 → 119
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:608 → 628
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:14 → 119
    BTB; BTB/POZ domain
    pfam13465
    Location:620 → 645
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    44991242..45012412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TQG0.1 GenPept UniProtKB/Swiss-Prot:Q7TQG0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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