U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Phf24 PHD finger protein 24 [ Mus musculus (house mouse) ]

Gene ID: 230085, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Phf24provided by MGI
Official Full Name
PHD finger protein 24provided by MGI
Primary source
MGI:MGI:2140712
See related
Ensembl:ENSMUSG00000036062 AllianceGenome:MGI:2140712
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GINIP
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception of pain; gamma-aminobutyric acid signaling pathway; and regulation of GABAergic synaptic transmission. Is expressed in male reproductive gland or organ; nervous system; retina; and small intestine. Orthologous to human PHF24 (PHD finger protein 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 28.7), frontal lobe adult (RPKM 19.6) and 4 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4 A5; 4 22.91 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (42872619..42944752)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (42872618..42944752)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930578G10 gene Neighboring gene predicted gene 9615 Neighboring gene spermatogenesis associated 31 subfamily F member 1A Neighboring gene STARR-seq mESC enhancer starr_10042 Neighboring gene spermatogenesis associated 31 subfamily F member 3 Neighboring gene predicted gene, 52697 Neighboring gene STARR-positive B cell enhancer ABC_E660 Neighboring gene DnaJ heat shock protein family (Hsp40) member B5 Neighboring gene SPATA31 subfamily G member 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Peripheral nerve injury induces loss of nociceptive neuron-specific Gαi-interacting protein in neuropathic pain rat. Liu Z, et al. Mol Pain, 2016. PMID 27145804, Free PMC Article
  2. Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions. Hoeffel G, et al. Nature, 2021 Jun. PMID 34012116
  3. GINIP, a Gαi-interacting protein, functions as a key modulator of peripheral GABAB receptor-mediated analgesia. Gaillard S, et al. Neuron, 2014 Oct 1. PMID 25242222, Free PMC Article
  4. Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae. Jiang D, et al. J Comp Neurol, 2020 Apr 1. PMID 31609468, Free PMC Article
  5. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GINIP is predominantly expressed by small nonpeptidergic nociceptive neurons and that nerve injury triggers loss of GINIP expression.
    Title: Peripheral nerve injury induces loss of nociceptive neuron-specific Gαi-interacting protein in neuropathic pain rat.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA1045, A230025O18

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
PHD finger protein 24

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346526.1 → NP_001333455.1  PHD finger protein 24 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Variants 1, 3, 4 and 6 encode the same isoform (1).
    Source sequence(s)
    AL672276, AL772334, CJ250336
    Consensus CDS
    CCDS84719.1
    UniProtKB/Swiss-Prot
    A2AG28, Q80TL4, Q8BH08
    Conserved Domains (1) summary
    pfam16744
    Location:126 → 198
    Zf_RING; KIAA1045 RING finger

  2. NM_001355693.1 → NP_001342622.1  PHD finger protein 24 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 3, 4 and 6 encode the same isoform (1).
    Source sequence(s)
    AK045544, AK138412, AW456637, BC057092, BM944560, BY289608, BY289935, CA327828, CJ114289, CX243634
    Consensus CDS
    CCDS84719.1
    UniProtKB/Swiss-Prot
    A2AG28, Q80TL4, Q8BH08
    Related
    ENSMUSP00000103609.2, ENSMUST00000107975.8
    Conserved Domains (1) summary
    pfam16744
    Location:126 → 198
    Zf_RING; KIAA1045 RING finger

  3. NM_001355694.1 → NP_001342623.1  PHD finger protein 24 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 3, 4 and 6 encode the same isoform (1).
    Source sequence(s)
    AK045544, AK138412, AL672276, AW456637, BC057092, CJ107729
    Consensus CDS
    CCDS84719.1
    UniProtKB/Swiss-Prot
    A2AG28, Q80TL4, Q8BH08
    Conserved Domains (1) summary
    pfam16744
    Location:126 → 198
    Zf_RING; KIAA1045 RING finger

  4. NM_001355695.1 → NP_001342624.1  PHD finger protein 24 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses alternate in-frame splice sites in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal in-frame segment, and is shorter, compared to isoform 1. Variants 2 and 5 encode the same isoform (2).
    Source sequence(s)
    AK038528, AK045544, AK138412, AW456637, CJ107729
    Consensus CDS
    CCDS18083.1
    Related
    ENSMUSP00000071011.3, ENSMUST00000069184.9
    Conserved Domains (1) summary
    pfam16744
    Location:89 → 161
    Zf_RING; KIAA1045 RING finger

  5. NM_001374110.1 → NP_001361039.1  PHD finger protein 24 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 3, 4 and 6 encode the same isoform (1)
    Source sequence(s)
    AL672276
    UniProtKB/Swiss-Prot
    A2AG28, Q80TL4, Q8BH08
    Conserved Domains (1) summary
    pfam16744
    Location:126 → 198
    Zf_RING; KIAA1045 RING finger

  6. NM_172690.3 → NP_766278.1  PHD finger protein 24 isoform 2

    See identical proteins and their annotated locations for NP_766278.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate in-frame splice sites in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal in-frame segment, and is shorter, compared to isoform 1. Variants 2 and 5 encode the same isoform (2).
    Source sequence(s)
    AK045544, AK138412, AW456637, BC057092, CJ107729
    Consensus CDS
    CCDS18083.1
    UniProtKB/Swiss-Prot
    Q80TL4
    Related
    ENSMUSP00000103610.3, ENSMUST00000107976.9
    Conserved Domains (1) summary
    pfam16744
    Location:89 → 161
    Zf_RING; KIAA1045 RING finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    42872619..42944752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253408.2 → XP_030109268.1  PHD finger protein 24 isoform X2

    UniProtKB/Swiss-Prot
    A2AG28, Q80TL4, Q8BH08
    Conserved Domains (1) summary
    pfam16744
    Location:126 → 198
    Zf_RING; KIAA1045 RING finger

  2. XM_030253409.2 → XP_030109269.1  PHD finger protein 24 isoform X2

    UniProtKB/Swiss-Prot
    A2AG28, Q80TL4, Q8BH08
    Conserved Domains (1) summary
    pfam16744
    Location:126 → 198
    Zf_RING; KIAA1045 RING finger

  3. XM_030253410.2 → XP_030109270.1  PHD finger protein 24 isoform X4

    Conserved Domains (1) summary
    pfam16744
    Location:89 → 161
    Zf_RING; KIAA1045 RING finger

  4. XM_017320124.3 → XP_017175613.1  PHD finger protein 24 isoform X4

    UniProtKB/Swiss-Prot
    Q80TL4
    Conserved Domains (1) summary
    pfam16744
    Location:89 → 161
    Zf_RING; KIAA1045 RING finger

  5. XM_036163987.1 → XP_036019880.1  PHD finger protein 24 isoform X5

    UniProtKB/TrEMBL
    F6SBE4
    Conserved Domains (1) summary
    pfam16744
    Location:1 → 67
    Zf_RING; KIAA1045 RING finger

  6. XM_030253411.1 → XP_030109271.1  PHD finger protein 24 isoform X5

    UniProtKB/TrEMBL
    F6SBE4
    Conserved Domains (1) summary
    pfam16744
    Location:1 → 67
    Zf_RING; KIAA1045 RING finger

  7. XM_006537819.4 → XP_006537882.1  PHD finger protein 24 isoform X4

    See identical proteins and their annotated locations for XP_006537882.1

    UniProtKB/Swiss-Prot
    Q80TL4
    Conserved Domains (1) summary
    pfam16744
    Location:89 → 161
    Zf_RING; KIAA1045 RING finger

  8. XM_006537809.4 → XP_006537872.1  PHD finger protein 24 isoform X1

    Conserved Domains (1) summary
    pfam16744
    Location:157 → 229
    Zf_RING; KIAA1045 RING finger

  9. XM_017320123.3 → XP_017175612.1  PHD finger protein 24 isoform X3

    Conserved Domains (1) summary
    pfam16744
    Location:99 → 171
    Zf_RING; KIAA1045 RING finger
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TL4.2 GenPept UniProtKB/Swiss-Prot:Q80TL4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous