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Kyat3 kynurenine aminotransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 229905, updated on 23-Mar-2024

Summary

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Official Symbol
Kyat3provided by MGI
Official Full Name
kynurenine aminotransferase 3provided by MGI
Primary source
MGI:MGI:2677849
See related
Ensembl:ENSMUSG00000040213 AllianceGenome:MGI:2677849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kat3; Ccbl2; KATIII
Summary
Enables kynurenine-glyoxylate transaminase activity; kynurenine-oxoglutarate transaminase activity; and protein homodimerization activity. Involved in 2-oxoglutarate metabolic process and kynurenine metabolic process. Located in mitochondrion. Orthologous to human KYAT3 (kynurenine aminotransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E18 (RPKM 19.4), liver adult (RPKM 18.7) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 H1; 3 66.69 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (142406780..142450672)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (142701019..142744911)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene guanylate binding protein 2, pseudogene Neighboring gene STARR-seq mESC enhancer starr_09160 Neighboring gene human immunodeficiency virus type I enhancer binding protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1270 Neighboring gene STARR-seq mESC enhancer starr_09161 Neighboring gene STARR-positive B cell enhancer mm9_chr3:142371757-142372058 Neighboring gene STARR-seq mESC enhancer starr_09162 Neighboring gene STARR-positive B cell enhancer ABC_E6141 Neighboring gene STARR-seq mESC enhancer starr_09163 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:142427870-142428053 Neighboring gene general transcription factor IIB Neighboring gene predicted gene, 24457 Neighboring gene predicted gene, 25965 Neighboring gene protein kinase N2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Biochemical and structural properties of mouse kynurenine aminotransferase III. Han Q, et al. Mol Cell Biol, 2009 Feb. PMID 19029248, Free PMC Article
  2. KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain. Lipinski M, et al. Nat Commun, 2020 May 22. PMID 32444594, Free PMC Article
  3. Kynurenine aminotransferase III and glutamine transaminase L are identical enzymes that have cysteine S-conjugate β-lyase activity and can transaminate L-selenomethionine. Pinto JT, et al. J Biol Chem, 2014 Nov 7. PMID 25231977, Free PMC Article
  4. Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases. Han Q, et al. BMC Biochem, 2010 May 19. PMID 20482848, Free PMC Article
  5. Genomic organization and expression analysis of mouse kynurenine aminotransferase II, a possible factor in the pathophysiology of Huntington's disease. Yu P, et al. Mamm Genome, 1999 Sep. PMID 10441733

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential Kat3 Coactivator Usage Regulates Brain Metabolism and Neuronal Differentiation.
    Title: Differential Kat3 Coactivator Usage Regulates Brain Metabolism and Neuronal Differentiation.
  2. KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain.
    Title: KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain.
  3. KAT III inhibited by equimolar methionine and half-life is 3.9 minutes at 65 degree C.
    Title: Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases.
  4. The biochemical and structural properties of mouse KAT III (mKAT III) were determined.
    Title: Biochemical and structural properties of mouse kynurenine aminotransferase III.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • C430041M20

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-S-conjugate beta-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables kynurenine-glyoxylate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kynurenine-oxoglutarate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kynurenine-oxoglutarate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in kynurenine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kynurenine--oxoglutarate transaminase 3
Names
cysteine conjugate-beta lyase 2
cysteine-S-conjugate beta-lyase 2
kynurenine aminotransferase III
kynurenine--glyoxylate transaminase
kynurenine--oxoglutarate transaminase III
NP_001280489.1
NP_776124.1
XP_006501494.1
XP_011238416.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293560.1 → NP_001280489.1  kynurenine--oxoglutarate transaminase 3 isoform1

    See identical proteins and their annotated locations for NP_001280489.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC115865, AK049569, AK145623
    Consensus CDS
    CCDS80040.1
    UniProtKB/Swiss-Prot
    Q71RI9, Q8BJ84
    Related
    ENSMUSP00000101825.2, ENSMUST00000106218.8
    Conserved Domains (2) summary
    cd00609
    Location:67 → 449
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PRK07777
    Location:45 → 450
    PRK07777; aminotransferase; Validated

  2. NM_173763.4 → NP_776124.1  kynurenine--oxoglutarate transaminase 3 isoform 2

    See identical proteins and their annotated locations for NP_776124.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in a 5' exon resulting in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC115865, AK049569, AK145623
    Consensus CDS
    CCDS17881.1
    UniProtKB/Swiss-Prot
    Q71RI9
    Related
    ENSMUSP00000041675.5, ENSMUST00000044392.11
    Conserved Domains (1) summary
    PRK07777
    Location:10 → 415
    PRK07777; putative succinyldiaminopimelate transaminase DapC

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    142406780..142450672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501431.3 → XP_006501494.1  kynurenine--oxoglutarate transaminase 3 isoform X1

    See identical proteins and their annotated locations for XP_006501494.1

    UniProtKB/Swiss-Prot
    Q71RI9
    Conserved Domains (1) summary
    PRK07777
    Location:10 → 415
    PRK07777; putative succinyldiaminopimelate transaminase DapC

  2. XM_011240114.4 → XP_011238416.1  kynurenine--oxoglutarate transaminase 3 isoform X1

    See identical proteins and their annotated locations for XP_011238416.1

    UniProtKB/Swiss-Prot
    Q71RI9
    Conserved Domains (1) summary
    PRK07777
    Location:10 → 415
    PRK07777; putative succinyldiaminopimelate transaminase DapC
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q71RI9.1 GenPept UniProtKB/Swiss-Prot:Q71RI9

Gene LinkOut

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