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Gbp7 guanylate binding protein 7 [ Mus musculus (house mouse) ]

Gene ID: 229900, updated on 27-Feb-2024

Summary

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Official Symbol
Gbp7provided by MGI
Official Full Name
guanylate binding protein 7provided by MGI
Primary source
MGI:MGI:2444421
See related
Ensembl:ENSMUSG00000040253 AllianceGenome:MGI:2444421
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GBP-7; 9830147J24Rik
Summary
Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within adhesion of symbiont to host and defense response to other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Is expressed in thymus primordium. Orthologous to human GBP7 (guanylate binding protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 4.7), liver E18 (RPKM 2.7) and 23 other tissues See more
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Genomic context

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Location:
3 H1; 3 66.69 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (142236097..142255912)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (142530336..142550151)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr3:142138865-142139166 Neighboring gene predicted gene, 54184 Neighboring gene STARR-positive B cell enhancer ABC_E3477 Neighboring gene STARR-positive B cell enhancer ABC_E4602 Neighboring gene guanylate binding protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E3478 Neighboring gene guanylate binding protein 3 Neighboring gene predicted gene, 40158 Neighboring gene STARR-positive B cell enhancer ABC_E10218 Neighboring gene STARR-positive B cell enhancer mm9_chr3:142263123-142263423 Neighboring gene guanylate binding protein 2b Neighboring gene predicted gene, 54185

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Biochemical and structural characterization of murine GBP7, a guanylate binding protein with an elongated C-terminal tail. Legewie L, et al. Biochem J, 2019 Nov 15. PMID 31689351
  2. Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus Replication by Suppressing Innate Immunity via NF-κB and JAK-STAT Signaling Pathways. Feng M, et al. J Virol, 2021 Feb 24. PMID 33408175, Free PMC Article
  3. Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection. Steffens N, et al. mBio, 2020 Jan 21. PMID 31964735, Free PMC Article
  4. Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Meunier E, et al. Nature, 2014 May 15. PMID 24739961
  5. In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. Olszewski MA, et al. J Interferon Cytokine Res, 2006 May. PMID 16689661

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus Replication by Suppressing Innate Immunity via NF-kappaB and JAK-STAT Signaling Pathways.
    Title: Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus Replication by Suppressing Innate Immunity via NF-κB and JAK-STAT Signaling Pathways.
  2. GBP7 exhibits a concentration-dependent GTPase activity and an apparent GTP turnover number of 20 min-1.
    Title: Biochemical and structural characterization of murine GBP7, a guanylate binding protein with an elongated C-terminal tail.
  3. findings show that at least 4 IFN-gamma-inducible Gbps--Gbp1, Gbp6, Gbp7, and Gbp10--conferred cell-autonomous immunity to listerial or mycobacterial infection within macrophages and gene-deficient animals
    Title: A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within adhesion of symbiont to host IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to interferon-beta IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytolysis in another organism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to protozoan IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to protozoan IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in symbiont-containing vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
guanylate-binding protein 7
Names
GTP-binding protein 7
guanine nucleotide-binding protein 7
guanylate-binding protein 4-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083312.2 → NP_001076781.1  guanylate-binding protein 7

    See identical proteins and their annotated locations for NP_001076781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC102108, AK087751
    Consensus CDS
    CCDS38657.1
    UniProtKB/Swiss-Prot
    Q6KAN1, Q78UK8, Q8BU48, Q91Z40
    Related
    ENSMUSP00000132970.2, ENSMUST00000171263.8
    Conserved Domains (3) summary
    pfam02841
    Location:283 → 579
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:18 → 281
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:289 → 579
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. NM_145545.4 → NP_663520.2  guanylate-binding protein 7

    See identical proteins and their annotated locations for NP_663520.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC102108, AK036666
    Consensus CDS
    CCDS38657.1
    UniProtKB/Swiss-Prot
    Q6KAN1, Q78UK8, Q8BU48, Q91Z40
    Related
    ENSMUSP00000049104.10, ENSMUST00000045097.11
    Conserved Domains (3) summary
    pfam02841
    Location:283 → 579
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:18 → 281
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:289 → 579
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    142236097..142255912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91Z40.2 GenPept UniProtKB/Swiss-Prot:Q91Z40

Gene LinkOut

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