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Cdc14a CDC14 cell division cycle 14A [ Mus musculus (house mouse) ]

Gene ID: 229776, updated on 21-Apr-2024

Summary

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Official Symbol
Cdc14aprovided by MGI
Official Full Name
CDC14 cell division cycle 14Aprovided by MGI
Primary source
MGI:MGI:2442676
See related
Ensembl:ENSMUSG00000033502 AllianceGenome:MGI:2442676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdc14; CDC14A2; CDC14a1; A830059A17Rik
Summary
Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Involved in sensory perception of sound. Located in kinociliary basal body and stereocilium tip. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study autosomal recessive nonsyndromic deafness 32. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 32. Orthologous to human CDC14A (cell division cycle 14A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 22.3), CNS E11.5 (RPKM 3.0) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 G1; 3 50.24 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (116066202..116222390, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (116272553..116428741, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08771 Neighboring gene G-protein coupled receptor 88 Neighboring gene predicted gene, 46839 Neighboring gene STARR-seq mESC enhancer starr_08772 Neighboring gene STARR-seq mESC enhancer starr_08773 Neighboring gene STARR-positive B cell enhancer ABC_E10208 Neighboring gene STARR-seq mESC enhancer starr_08775 Neighboring gene STARR-positive B cell enhancer ABC_E2097 Neighboring gene STARR-positive B cell enhancer ABC_E3463 Neighboring gene predicted gene, 40125 Neighboring gene predicted gene, 22361 Neighboring gene predicted gene, 26358

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells. Villarroya-Beltri C, et al. EMBO J, 2023 Jan 4. PMID 36326833, Free PMC Article
  2. Cdc14a has a role in spermatogenesis, sperm maturation and male fertility. Wen Z, et al. Exp Cell Res, 2020 Oct 1. PMID 32679235
  3. The role of Cdc14 phosphatases in the control of cell division. Clifford DM, et al. Biochem Soc Trans, 2008 Jun. PMID 18481975
  4. Phospho‑regulation of Cdc14A by polo‑like kinase 1 is involved in β‑cell function and cell cycle regulation. Hu H, et al. Mol Med Rep, 2019 Nov. PMID 31545409
  5. Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair. Lin H, et al. Mol Cell Biol, 2015 Nov. PMID 26283732, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells.
    Title: Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells.
  2. Cdc14a has a role in spermatogenesis, sperm maturation and male fertility.
    Title: Cdc14a has a role in spermatogenesis, sperm maturation and male fertility.
  3. PLK1 promoted cell proliferation and insulin secretion while inhibiting cellular apoptosis in betaTC3 cell lines under both low and high glucose conditions. In addition, the phosphoregulation of Cdc14A by PLK1 may be involved in betaTC3 cell cycle regulation and insulin secretion under high glucose conditions.
    Title: Phospho‑regulation of Cdc14A by polo‑like kinase 1 is involved in β‑cell function and cell cycle regulation.
  4. CDC14A activity is necessary for hearing and male fertility.
    Title: CDC14A phosphatase is essential for hearing and male fertility in mouse and human.
  5. Cdc14B knockout (Cdc14B(-/-)) mouse embryonic fibroblasts showed defects in repairing ionizing radiation-induced DNA double-strand breaks, which occurred only at late passages when Cdc14A levels were low.
    Title: Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.
  6. CDC14A regulates oocyte maturation and functions to promote the meiosis I-to-meiosis II transition as its homolog does in budding yeast.
    Title: The CDC14A phosphatase regulates oocyte maturation in mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of exit from mitosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in kinociliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinocilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stereocilium tip IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dual specificity protein phosphatase CDC14A
Names
CDC14 cell division cycle 14 homolog A
NP_001074287.1
NP_001167024.1
NP_001342575.1
NP_001365922.1
NP_001365923.1
XP_017175051.1
XP_030108457.1
XP_036018972.1
XP_036018973.1
XP_036018974.1
XP_036018975.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080818.2 → NP_001074287.1  dual specificity protein phosphatase CDC14A isoform 1

    See identical proteins and their annotated locations for NP_001074287.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AK052560, AK142294, BC072644
    Consensus CDS
    CCDS38611.1
    UniProtKB/Swiss-Prot
    Q6GQT0, Q8BZ66
    Related
    ENSMUSP00000087950.5, ENSMUST00000090464.7
    Conserved Domains (3) summary
    COG2453
    Location:175 → 329
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    pfam14671
    Location:17 → 152
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:187 → 326
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. NM_001173553.2 → NP_001167024.1  dual specificity protein phosphatase CDC14A isoform 2

    See identical proteins and their annotated locations for NP_001167024.1

    Status: VALIDATED

    Source sequence(s)
    AK142294, BC072644
    Consensus CDS
    CCDS51058.1
    UniProtKB/Swiss-Prot
    Q6GQT0
    Related
    ENSMUSP00000102100.3, ENSMUST00000106491.7
    Conserved Domains (3) summary
    COG2453
    Location:126 → 280
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    pfam14671
    Location:17 → 108
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:138 → 277
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  3. NM_001355646.1 → NP_001342575.1  dual specificity protein phosphatase CDC14A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC165364, BC072644
    Conserved Domains (1) summary
    cl28904
    Location:1 → 43
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  4. NM_001378993.1 → NP_001365922.1  dual specificity protein phosphatase CDC14A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC165364
    Conserved Domains (2) summary
    cd14499
    Location:163 → 336
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:10 → 154
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

  5. NM_001378994.1 → NP_001365923.1  dual specificity protein phosphatase CDC14A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC165364
    UniProtKB/TrEMBL
    A0A5F8MPZ4
    Related
    ENSMUSP00000159189.2, ENSMUST00000239145.2
    Conserved Domains (2) summary
    cd14499
    Location:105 → 278
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:1 → 96
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    116066202..116222390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163080.1 → XP_036018973.1  dual specificity protein phosphatase CDC14A isoform X2

    Conserved Domains (2) summary
    cd14499
    Location:178 → 351
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:10 → 169
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

  2. XM_036163082.1 → XP_036018975.1  dual specificity protein phosphatase CDC14A isoform X4

    Conserved Domains (1) summary
    cl28904
    Location:1 → 43
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. XM_036163079.1 → XP_036018972.1  dual specificity protein phosphatase CDC14A isoform X1

    Conserved Domains (2) summary
    cd14499
    Location:178 → 351
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:10 → 169
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

  4. XM_036163081.1 → XP_036018974.1  dual specificity protein phosphatase CDC14A isoform X3

    Conserved Domains (1) summary
    cl28904
    Location:1 → 43
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  5. XM_030252597.2 → XP_030108457.1  dual specificity protein phosphatase CDC14A isoform X3

    Conserved Domains (1) summary
    cl28904
    Location:1 → 43
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  6. XM_017319562.3 → XP_017175051.1  dual specificity protein phosphatase CDC14A isoform X3

    Conserved Domains (1) summary
    cl28904
    Location:1 → 43
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RNA

  1. XR_004941316.1 RNA Sequence

  2. XR_004941317.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6GQT0.2 GenPept UniProtKB/Swiss-Prot:Q6GQT0

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