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Slc25a24 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24 [ Mus musculus (house mouse) ]

Gene ID: 229731, updated on 11-Apr-2024

Summary

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Official Symbol
Slc25a24provided by MGI
Official Full Name
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24provided by MGI
Primary source
MGI:MGI:1917160
See related
Ensembl:ENSMUSG00000040322 AllianceGenome:MGI:1917160
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SCaMC-1; 2610016M12Rik
Summary
Predicted to enable ATP transmembrane transporter activity and calcium ion binding activity. Predicted to be involved in several processes, including ATP transport; cellular response to calcium ion; and cellular response to oxidative stress. Located in mitochondrion. Is expressed in cartilage; genitourinary system; and trachea. Orthologous to human SLC25A24 (solute carrier family 25 member 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 19.5), large intestine adult (RPKM 18.1) and 21 other tissues See more
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Genomic context

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Location:
3 F3; 3 48.13 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (109030465..109075725)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (109123149..109168409)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 54 Neighboring gene predicted gene, 19391 Neighboring gene STARR-seq mESC enhancer starr_08697 Neighboring gene zona pellucida binding protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:109144693-109144846 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:109164872-109165133 Neighboring gene vav 3 oncogene Neighboring gene STARR-positive B cell enhancer mm9_chr3:109251268-109251568 Neighboring gene STARR-seq mESC enhancer starr_08700 Neighboring gene STARR-seq mESC enhancer starr_08701 Neighboring gene STARR-seq mESC enhancer starr_08702 Neighboring gene STARR-seq mESC enhancer starr_08703

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SLC25A24 as a novel susceptibility gene for low fat mass in humans and mice. Urano T, et al. J Clin Endocrinol Metab, 2015 Apr. PMID 25599384
  2. SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering. Traba J, et al. Cell Death Differ, 2012 Apr. PMID 22015608, Free PMC Article
  3. Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+ activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3. Amigo I, et al. J Biol Chem, 2013 Mar 15. PMID 23344948, Free PMC Article
  4. Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains. del Arco A, et al. J Biol Chem, 2004 Jun 4. PMID 15054102
  5. The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Rinschen MM, et al. Hum Mol Genet, 2016 Apr 1. PMID 26792178, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arginine-methylated c-Myc affects mitochondrial mitophagy in mouse acute kidney injury via Slc25a24.
    Title: Arginine-methylated c-Myc affects mitochondrial mitophagy in mouse acute kidney injury via Slc25a24.
  2. Genetic analyses in human and mouse models revealed the importance of SLC25A24/Slc25a24 in the regulation of body fat mass and adipogenesis.
    Title: SLC25A24 as a novel susceptibility gene for low fat mass in humans and mice.
  3. SCaMC-1 exerts a negative feedback control between cellular Ca(2+) overload and mPT-dependent cell death, suggesting that the carrier might represent a novel target for cancer therapy.
    Title: SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP:phosphate antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP:phosphate antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables adenine nucleotide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ADP transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ATP transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenine nucleotide transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial ATP transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial adenyl nucleotide antiporter SLC25A24
Names
calcium-binding mitochondrial carrier protein SCaMC-1
small calcium-binding mitochondrial carrier protein 1
solute carrier family 25 member 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172685.3 → NP_766273.1  mitochondrial adenyl nucleotide antiporter SLC25A24

    See identical proteins and their annotated locations for NP_766273.1

    Status: PROVISIONAL

    Source sequence(s)
    AL671921, AL845310
    Consensus CDS
    CCDS17772.1
    UniProtKB/Swiss-Prot
    Q3TCQ2, Q3THY3, Q7TPC2, Q8BMD8
    Related
    ENSMUSP00000029477.7, ENSMUST00000029477.11
    Conserved Domains (4) summary
    cd00051
    Location:28 → 85
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    PTZ00169
    Location:199 → 470
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:194 → 281
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:25 → 84
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    109030465..109075725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMD8.1 GenPept UniProtKB/Swiss-Prot:Q8BMD8

Gene LinkOut

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