Amigo1 adhesion molecule with Ig like domain 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Amigo1provided by MGI
Official Full Name: adhesion molecule with Ig like domain 1provided by MGI
Primary source: MGI:MGI:2653612
See related: Ensembl:ENSMUSG00000050947 AllianceGenome:MGI:2653612
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ali2; Amigo
Summary: Enables potassium channel regulator activity. Involved in positive regulation of potassium ion transmembrane transport. Acts upstream of or within positive regulation of synapse assembly. Located in dendrite and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human AMIGO1 (adhesion molecule with Ig like domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 13.9), cerebellum adult (RPKM 10.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.3; 3 46.86 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (108093605..108099602)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (108186289..108192286)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The AMIGO1-KCNB1 complex is involved in schizophrenia-related behavioral domains in mice.
Title: AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related Phenotypes.
Data show that AMIGO is a glycosylated protein widely expressed in the central nervous system (CNS), and can be found in neurons, astrocytes as well as oligodendrocytes.
Title: AMIGO is expressed in multiple brain cell types and may regulate dendritic growth and neuronal survival.
AMIGO is a function-modulating auxiliary subunit for Kv2.1.
Title: AMIGO is an auxiliary subunit of the Kv2.1 potassium channel.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Amigo1 (e-PCR), detects polymorphism
- UniSTS:525534

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables potassium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axonal fasciculation	ISO Inferred from Sequence Orthology more info
involved_in axonal fasciculation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info	PubMed
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to L-glutamate	ISO Inferred from Sequence Orthology more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in myelination	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection fasciculation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axonogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in pericellular basket	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: amphoterin-induced protein 1

Names: AMIGO-1; alivin 2; amphoterin induced gene and ORF (Amigo)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004293.3 → NP_001004293.1 amphoterin-induced protein 1 isoform a precursor

See identical proteins and their annotated locations for NP_001004293.1

Status: VALIDATED

Source sequence(s)

AL671854

Consensus CDS

CCDS17753.1

UniProtKB/Swiss-Prot

A2AE40, Q69ZQ0, Q80ZD8, Q8R5D4, Q921U9

Related

ENSMUSP00000102267.2, ENSMUST00000106656.2

Conserved Domains (5) summary

smart00410
Location:279 → 357

IG_like; Immunoglobulin like

cd00116
Location:64 → 198

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:44 → 64

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:110 → 170

LRR_8; Leucine rich repeat

cl11960
Location:283 → 342

Ig; Immunoglobulin domain
NM_001287093.2 → NP_001274022.1 amphoterin-induced protein 1 isoform b precursor

Status: VALIDATED

Source sequence(s)

AL671854

Consensus CDS

CCDS71305.1

UniProtKB/Swiss-Prot

Q80ZD8

Related

ENSMUSP00000102270.3, ENSMUST00000106659.3

Conserved Domains (2) summary

PRK15370
Location:30 → 213

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

sd00033
Location:44 → 64

LRR_RI; leucine-rich repeat [structural motif]
NM_001411560.1 → NP_001398489.1 amphoterin-induced protein 1 isoform a precursor

Status: VALIDATED

Source sequence(s)

AL671854

UniProtKB/Swiss-Prot

A2AE40, Q69ZQ0, Q80ZD8, Q8R5D4, Q921U9
NM_001411561.1 → NP_001398490.1 amphoterin-induced protein 1 isoform a precursor

Status: VALIDATED

Source sequence(s)

AL671854

UniProtKB/Swiss-Prot

A2AE40, Q69ZQ0, Q80ZD8, Q8R5D4, Q921U9
NM_001411562.1 → NP_001398491.1 amphoterin-induced protein 1 isoform d precursor

Status: VALIDATED

Source sequence(s)

AL671854
NM_001411563.1 → NP_001398492.1 amphoterin-induced protein 1 isoform d precursor

Status: VALIDATED

Source sequence(s)

AL671854
NM_001411564.1 → NP_001398493.1 amphoterin-induced protein 1 isoform e precursor

Status: VALIDATED

Source sequence(s)

AL671854
NM_001411565.1 → NP_001398494.1 amphoterin-induced protein 1 isoform e precursor

Status: VALIDATED

Source sequence(s)

AL671854
NM_146137.4 → NP_666249.2 amphoterin-induced protein 1 isoform a precursor

See identical proteins and their annotated locations for NP_666249.2

Status: VALIDATED

Source sequence(s)

AL671854

Consensus CDS

CCDS17753.1

UniProtKB/Swiss-Prot

A2AE40, Q69ZQ0, Q80ZD8, Q8R5D4, Q921U9

Related

ENSMUSP00000061244.7, ENSMUST00000050909.7

Conserved Domains (5) summary

smart00410
Location:279 → 357

IG_like; Immunoglobulin like

cd00116
Location:64 → 198

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:44 → 64

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:110 → 170

LRR_8; Leucine rich repeat

cl11960
Location:283 → 342

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

108093605..108099602

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163076.1 → XP_036018969.1 amphoterin-induced protein 1 isoform X1

Conserved Domains (2) summary

PRK15370
Location:30 → 213

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

sd00033
Location:44 → 64

LRR_RI; leucine-rich repeat [structural motif]