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Slc16a4 solute carrier family 16 (monocarboxylic acid transporters), member 4 [ Mus musculus (house mouse) ]

Gene ID: 229699, updated on 11-Apr-2024

Summary

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Official Symbol
Slc16a4provided by MGI
Official Full Name
solute carrier family 16 (monocarboxylic acid transporters), member 4provided by MGI
Primary source
MGI:MGI:2385183
See related
Ensembl:ENSMUSG00000027896 AllianceGenome:MGI:2385183
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MCT 5
Summary
Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in choroid plexus; cranium; otic capsule; and thoracic segment skeleton. Orthologous to human SLC16A4 (solute carrier family 16 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 15.5), limb E14.5 (RPKM 2.4) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Slc16a4 in Genome Data Viewer
Location:
3 F2.3; 3 46.81 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107198543..107219437)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107291230..107312115)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A630076J17 gene Neighboring gene STARR-positive B cell enhancer ABC_E6103 Neighboring gene prokineticin 1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:107081789-107082089 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 Neighboring gene RNA binding motif protein 15 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:107136515-107136698 Neighboring gene STARR-seq mESC enhancer starr_08664 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide pseudogene Neighboring gene predicted gene, 35700

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer. Babu E, et al. Biochem J, 2015 Jul 1. PMID 26173258
  2. Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice. Pierre K, et al. J Physiol, 2007 Sep 1. PMID 17599960, Free PMC Article
  3. Distribution of monocarboxylate transporters in the peripheral nervous system suggests putative roles in lactate shuttling and myelination. Domènech-Estévez E, et al. J Neurosci, 2015 Mar 11. PMID 25762662, Free PMC Article
  4. Lipid signatures reflect the function of the murine primary placentation†. Lee JG, et al. Biol Reprod, 2022 Mar 19. PMID 34850819
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study showed that mouse MCT1, MCT2, and MCT4 are expressed in the PNS. While DRG neurons express MCT1, myelinating Schwann cells.
    Title: Distribution of monocarboxylate transporters in the peripheral nervous system suggests putative roles in lactate shuttling and myelination.
  2. Expression of cerebral MCT isoforms can be modulated by alterations of peripheral metabolism, suggesting that the adult brain is sensitive and adapts to new metabolic states.
    Title: Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Clone Names

  • MGC37305

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
monocarboxylate transporter 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310705.2 → NP_001297634.1  monocarboxylate transporter 5 isoform 2

    See identical proteins and their annotated locations for NP_001297634.1

    Status: VALIDATED

    Source sequence(s)
    AC132405
    Consensus CDS
    CCDS79997.1
    UniProtKB/Swiss-Prot
    Q8R0M8
    Related
    ENSMUSP00000102334.2, ENSMUST00000106723.2
    Conserved Domains (2) summary
    cd06174
    Location:24 → 198
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:27 → 447
    MFS_1; Major Facilitator Superfamily

  2. NM_146136.3 → NP_666248.1  monocarboxylate transporter 5 isoform 1

    See identical proteins and their annotated locations for NP_666248.1

    Status: VALIDATED

    Source sequence(s)
    AC132405
    Consensus CDS
    CCDS17736.1
    UniProtKB/Swiss-Prot
    Q8BLA5, Q8BWE3, Q8R0M8, Q8R157
    Related
    ENSMUSP00000029502.8, ENSMUST00000029502.14
    Conserved Domains (2) summary
    cd06174
    Location:24 → 482
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:7 → 479
    2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    107198543..107219437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163075.1 → XP_036018968.1  monocarboxylate transporter 5 isoform X1

    Conserved Domains (1) summary
    cl28910
    Location:20 → 461
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0M8.1 GenPept UniProtKB/Swiss-Prot:Q8R0M8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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