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St7l suppression of tumorigenicity 7-like [ Mus musculus (house mouse) ]

Gene ID: 229681, updated on 5-Mar-2024

Summary

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Official Symbol
St7lprovided by MGI
Official Full Name
suppression of tumorigenicity 7-likeprovided by MGI
Primary source
MGI:MGI:2386964
See related
Ensembl:ENSMUSG00000045576 AllianceGenome:MGI:2386964
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
St7r
Summary
Involved in negative regulation of cell growth. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including genitourinary system; inner ear; liver; lung; and spleen. Orthologous to human ST7L (suppression of tumorigenicity 7 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 3.0), limb E14.5 (RPKM 2.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.2; 3 45.88 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (104771822..104837384)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (104864506..104949328)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene Mov10 RISC complex RNA helicase Neighboring gene STARR-seq mESC enhancer starr_08622 Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:104667925-104668034 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08625 Neighboring gene wingless-type MMTV integration site family, member 2B Neighboring gene predicted gene, 46819

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ST7-mediated suppression of tumorigenicity of prostate cancer cells is characterized by remodeling of the extracellular matrix. Hooi CF, et al. Oncogene, 2006 Jun 29. PMID 16474848
  2. Molecular cloning and characterization of mouse St7r (St7-like, St7l). Saitoh T, et al. Int J Mol Med, 2002 Jul. PMID 12060862
  3. Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule. Ficker M, et al. Dev Biol, 2004 Apr 1. PMID 15031101
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the first report on molecular cloning and initial characterization of mouse St7r
    Title: Molecular cloning and characterization of mouse St7r (St7-like, St7l).
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC130399

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
suppressor of tumorigenicity 7 protein-like
Names
ST7-related protein
tumor suppressor ST7 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253702.1 → NP_001240631.1  suppressor of tumorigenicity 7 protein-like isoform 2

    See identical proteins and their annotated locations for NP_001240631.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC166156, AI834981, AK030273, BC058781
    Consensus CDS
    CCDS57250.1
    UniProtKB/Swiss-Prot
    Q8K4P7
    UniProtKB/TrEMBL
    Q8CDC5
    Related
    ENSMUSP00000102380.2, ENSMUST00000106769.8
    Conserved Domains (1) summary
    cd11557
    Location:75 → 510
    ST7; Suppression of tumorigenicity 7

  2. NM_001253703.1 → NP_001240632.1  suppressor of tumorigenicity 7 protein-like isoform 3

    See identical proteins and their annotated locations for NP_001240632.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame internal segment compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC166156, AI834981, AK030273, AK144075
    Consensus CDS
    CCDS79994.1
    UniProtKB/Swiss-Prot
    Q8K4P7
    UniProtKB/TrEMBL
    Q8CDC5
    Related
    ENSMUSP00000143759.2, ENSMUST00000200132.5
    Conserved Domains (1) summary
    cd11557
    Location:75 → 464
    ST7; Suppression of tumorigenicity 7

  3. NM_153091.3 → NP_694731.1  suppressor of tumorigenicity 7 protein-like isoform 1

    See identical proteins and their annotated locations for NP_694731.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC166156, AI834981, AK030273, BC058781
    Consensus CDS
    CCDS17705.1
    UniProtKB/Swiss-Prot
    Q3T9Y2, Q3UNR1, Q8K4P7
    Related
    ENSMUSP00000058455.7, ENSMUST00000059271.13
    Conserved Domains (1) summary
    cd11557
    Location:75 → 542
    ST7; Suppression of tumorigenicity 7

RNA

  1. NR_045578.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of an exon compared to variant 1, that causes a frameshift. This transcript is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC166156, AI834981, AK030273, AK148099, BC058781

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    104771822..104837384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252589.2 → XP_030108449.1  suppressor of tumorigenicity 7 protein-like isoform X1

    Conserved Domains (1) summary
    cd11557
    Location:1 → 330
    ST7; Suppression of tumorigenicity 7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4P7.1 GenPept UniProtKB/Swiss-Prot:Q8K4P7

Gene LinkOut

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