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Otud7b OTU domain containing 7B [ Mus musculus (house mouse) ]

Gene ID: 229603, updated on 21-Apr-2024

Summary

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Official Symbol
Otud7bprovided by MGI
Official Full Name
OTU domain containing 7Bprovided by MGI
Primary source
MGI:MGI:2654703
See related
Ensembl:ENSMUSG00000038495 AllianceGenome:MGI:2654703
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Za20d1; CEZANNE; Trabid2; 2900060B22Rik; 4930463P07Rik
Summary
Enables K63-linked polyubiquitin modification-dependent protein binding activity and thiol-dependent deubiquitinase. Involved in several processes, including negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of transcription by RNA polymerase II; and protein K48-linked deubiquitination. Acts upstream of or within in utero embryonic development and protein deubiquitination. Located in cytoplasm. Orthologous to human OTUD7B (OTU deubiquitinase 7B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 8.7), lung adult (RPKM 6.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.1; 3 41.65 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96011759..96068446)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96104504..96161129)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 45 Neighboring gene STARR-positive B cell enhancer ABC_E2674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:95861936-95862045 Neighboring gene predicted gene, 54210 Neighboring gene STARR-positive B cell enhancer ABC_E6079 Neighboring gene predicted gene, 30044 Neighboring gene STARR-positive B cell enhancer ABC_E4561 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:95976180-95976363 Neighboring gene STARR-seq mESC enhancer starr_08407 Neighboring gene myotubularin related protein 11 Neighboring gene predicted gene, 22027 Neighboring gene splicing factor 3b, subunit 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling. An W, et al. Cardiovasc Res, 2022 Jan 29. PMID 33599243, Free PMC Article
  2. The Clock-Controlled lncRNA-AK028245 Participates in the Immune Response via Immune Response Factors OTUD7B and A20. Qi F, et al. J Biol Rhythms, 2020 Dec. PMID 32748687
  3. Downregulation of miR-146a-5p Inhibits Choroidal Neovascularization via the NF-κB Signaling Pathway by Targeting OTUD7B. Li L, et al. Curr Eye Res, 2020 Dec. PMID 32438838
  4. Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma. Wang JH, et al. Cell Death Dis, 2017 Sep 7. PMID 28880268, Free PMC Article
  5. Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner. Bremm A, et al. EMBO Rep, 2014 Dec. PMID 25355043, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ovarian Tumor Domain-Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Kruppel-Like Factor 4.
    Title: Ovarian Tumor Domain-Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Krüppel-Like Factor 4.
  2. The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2.
    Title: The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2.
  3. Cezanne is a critical regulator of pathological arterial remodelling by targeting beta-catenin signalling.
    Title: Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling.
  4. OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis.
    Title: OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis.
  5. Downregulation of miR-146a-5p Inhibits Choroidal Neovascularization via the NF-kappaB Signaling Pathway by Targeting OTUD7B.
    Title: Downregulation of miR-146a-5p Inhibits Choroidal Neovascularization via the NF-κB Signaling Pathway by Targeting OTUD7B.
  6. The Clock-Controlled lncRNA-AK028245 Participates in the Immune Response via Immune Response Factors OTUD7B and A20.
    Title: The Clock-Controlled lncRNA-AK028245 Participates in the Immune Response via Immune Response Factors OTUD7B and A20.
  7. Cezanne may be a novel antioncogene that has a pivotal role in the invasion of hepatocellular carcinoma.
    Title: Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma.
  8. TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling
    Title: TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.
  9. These findings establish Otud7b as a positive regulator of T cell receptor-proximal signaling and T cell activation, highlighting the importance of deubiquitination in regulating Zap70 function.
    Title: Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination.
  10. Inflammatory responses to ischemia are controlled by a balance between ubiquitination and deubiquitination, and Cezanne is a key regulator of this process.
    Title: Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mucosal immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked deubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
OTU domain-containing protein 7B
Names
TRAF binding domain containing 2
cellular zinc finger anti-NF-kappa-B protein
zinc finger A20 domain-containing protein 1
zinc finger protein Cezanne
zinc finger, A20 domain containing 1
NP_001020784.1
NP_001020785.1
XP_006501448.1
XP_006501449.1
XP_006501452.1
XP_017175035.1
XP_017175037.1
XP_030108444.1
XP_030108445.1
XP_036018961.1
XP_036018962.1
XP_036018963.1
XP_036018964.1
XP_036018965.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025613.1 → NP_001020784.1  OTU domain-containing protein 7B

    See identical proteins and their annotated locations for NP_001020784.1

    Status: VALIDATED

    Source sequence(s)
    AC092094, AK044701, BB596613
    Consensus CDS
    CCDS17629.1
    UniProtKB/Swiss-Prot
    B2RUR8, Q8CFS0
    Related
    ENSMUSP00000088291.3, ENSMUST00000090785.9
    Conserved Domains (3) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:798 → 820
    zf-A20; A20-like zinc finger
    cl19932
    Location:189 → 359
    OTU; OTU-like cysteine protease

  2. NM_001025614.1 → NP_001020785.1  OTU domain-containing protein 7B

    See identical proteins and their annotated locations for NP_001020785.1

    Status: VALIDATED

    Source sequence(s)
    AC092094, AK044701, BB596613
    Consensus CDS
    CCDS17629.1
    UniProtKB/Swiss-Prot
    B2RUR8, Q8CFS0
    Related
    ENSMUSP00000046413.6, ENSMUST00000035519.12
    Conserved Domains (3) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:798 → 820
    zf-A20; A20-like zinc finger
    cl19932
    Location:189 → 359
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    96011759..96068446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252585.2 → XP_030108445.1  OTU domain-containing protein 7B isoform X2

    Conserved Domains (2) summary
    pfam01754
    Location:706 → 728
    zf-A20; A20-like zinc finger
    cl19932
    Location:97 → 267
    OTU; OTU-like cysteine protease

  2. XM_036163070.1 → XP_036018963.1  OTU domain-containing protein 7B isoform X1

    UniProtKB/Swiss-Prot
    B2RUR8, Q8CFS0
    Conserved Domains (3) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:798 → 820
    zf-A20; A20-like zinc finger
    cl19932
    Location:189 → 359
    OTU; OTU-like cysteine protease

  3. XM_030252584.2 → XP_030108444.1  OTU domain-containing protein 7B isoform X2

    Conserved Domains (2) summary
    pfam01754
    Location:706 → 728
    zf-A20; A20-like zinc finger
    cl19932
    Location:97 → 267
    OTU; OTU-like cysteine protease

  4. XM_017319548.3 → XP_017175037.1  OTU domain-containing protein 7B isoform X2

    Conserved Domains (2) summary
    pfam01754
    Location:706 → 728
    zf-A20; A20-like zinc finger
    cl19932
    Location:97 → 267
    OTU; OTU-like cysteine protease

  5. XM_036163068.1 → XP_036018961.1  OTU domain-containing protein 7B isoform X1

    UniProtKB/Swiss-Prot
    B2RUR8, Q8CFS0
    Conserved Domains (3) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:798 → 820
    zf-A20; A20-like zinc finger
    cl19932
    Location:189 → 359
    OTU; OTU-like cysteine protease

  6. XM_006501385.4 → XP_006501448.1  OTU domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_006501448.1

    UniProtKB/Swiss-Prot
    B2RUR8, Q8CFS0
    Conserved Domains (3) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:798 → 820
    zf-A20; A20-like zinc finger
    cl19932
    Location:189 → 359
    OTU; OTU-like cysteine protease

  7. XM_036163069.1 → XP_036018962.1  OTU domain-containing protein 7B isoform X2

    Conserved Domains (2) summary
    pfam01754
    Location:706 → 728
    zf-A20; A20-like zinc finger
    cl19932
    Location:97 → 267
    OTU; OTU-like cysteine protease

  8. XM_006501389.4 → XP_006501452.1  OTU domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_006501452.1

    UniProtKB/Swiss-Prot
    B2RUR8, Q8CFS0
    Conserved Domains (3) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:798 → 820
    zf-A20; A20-like zinc finger
    cl19932
    Location:189 → 359
    OTU; OTU-like cysteine protease

  9. XM_006501386.3 → XP_006501449.1  OTU domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_006501449.1

    UniProtKB/Swiss-Prot
    B2RUR8, Q8CFS0
    Related
    ENSMUSP00000096449.3, ENSMUST00000098849.3
    Conserved Domains (3) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:798 → 820
    zf-A20; A20-like zinc finger
    cl19932
    Location:189 → 359
    OTU; OTU-like cysteine protease

  10. XM_036163071.1 → XP_036018964.1  OTU domain-containing protein 7B isoform X2

    Conserved Domains (2) summary
    pfam01754
    Location:706 → 728
    zf-A20; A20-like zinc finger
    cl19932
    Location:97 → 267
    OTU; OTU-like cysteine protease

  11. XM_036163072.1 → XP_036018965.1  OTU domain-containing protein 7B isoform X2

    Conserved Domains (2) summary
    pfam01754
    Location:706 → 728
    zf-A20; A20-like zinc finger
    cl19932
    Location:97 → 267
    OTU; OTU-like cysteine protease

  12. XM_017319546.1 → XP_017175035.1  OTU domain-containing protein 7B isoform X1

    UniProtKB/Swiss-Prot
    B2RUR8, Q8CFS0
    Conserved Domains (3) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:798 → 820
    zf-A20; A20-like zinc finger
    cl19932
    Location:189 → 359
    OTU; OTU-like cysteine protease
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RUR8.1 GenPept UniProtKB/Swiss-Prot:B2RUR8

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