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Adamtsl4 ADAMTS-like 4 [ Mus musculus (house mouse) ]

Gene ID: 229595, updated on 21-Apr-2024

Summary

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Official Symbol
Adamtsl4provided by MGI
Official Full Name
ADAMTS-like 4provided by MGI
Primary source
MGI:MGI:2389008
See related
Ensembl:ENSMUSG00000015850 AllianceGenome:MGI:2389008
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tsrc1; ADAMTSL-4
Summary
The protein encoded by this gene is a member of the ADAMTS superfamily of secreted proteins, which contain a metalloprotease domain at the N-terminus and a C-terminal ancillary domain. ADAMTS-like proteins lack protease activity and resemble the ancillary domain of ADAMTS proteins. ADAMTS-like proteins have been implicated in regulation of the extracellular matrix. The encoded protein contains 7 thrombospondin type 1 repeats, a conserved extracellular domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Expression
Broad expression in lung adult (RPKM 18.4), bladder adult (RPKM 18.2) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.1; 3 40.74 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95583511..95595232, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95676201..95687927, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10, pseudogene 1 Neighboring gene endosulfine alpha Neighboring gene CRISPRi-validated Mcl1 enhancer cluster Neighboring gene STARR-seq mESC enhancer starr_08389 Neighboring gene STARR-seq mESC enhancer starr_08391 Neighboring gene myeloid cell leukemia sequence 1 Neighboring gene STARR-seq mESC enhancer starr_08393 Neighboring gene STARR-seq mESC enhancer starr_08394 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:95511513-95511622 Neighboring gene microRNA 7014 Neighboring gene extracellular matrix protein 1 Neighboring gene threonyl-tRNA synthetase 2, mitochondrial (putative) Neighboring gene STARR-positive B cell enhancer ABC_E2087

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic and functional linkage between ADAMTS superfamily proteins and fibrillin-1: a novel mechanism influencing microfibril assembly and function. Hubmacher D, et al. Cell Mol Life Sci, 2011 Oct. PMID 21858451, Free PMC Article
  2. TSRC1, a widely expressed gene containing seven thrombospondin type I repeats. Buchner DA, et al. Gene, 2003 Mar 27. PMID 12706885
  3. Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation. Collin GB, et al. Hum Mol Genet, 2015 Dec 15. PMID 26405179, Free PMC Article
  4. O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Du J, et al. Dev Biol, 2010 Oct 1. PMID 20637190, Free PMC Article
  5. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the first ADAMTSL4 mouse model, tvrm267, bearing a nonsense mutation in Adamtsl4
    Title: Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation.
  2. O-fucose modification of thrombospondin type 1 repeats was essential for modulation of growth factor signaling during gastrulation.
    Title: O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28749

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within epithelial cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within extracellular matrix organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within pigment cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in interstitial matrix IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ADAMTS-like protein 4
Names
thrombospondin repeat containing 1
thrombospondin repeat protein 1
thrombospondin repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301705.1 → NP_001288634.1  ADAMTS-like protein 4 precursor

    See identical proteins and their annotated locations for NP_001288634.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093317, AI595354, AY158701, BY196249, BY204619
    Consensus CDS
    CCDS17618.1
    UniProtKB/Swiss-Prot
    Q148X6, Q80T21
    Related
    ENSMUSP00000113424.2, ENSMUST00000117782.8
    Conserved Domains (5) summary
    smart00209
    Location:46 → 70
    TSP1; Thrombospondin type 1 repeats
    PHA03247
    Location:161 → 360
    PHA03247; large tegument protein UL36; Provisional
    pfam05986
    Location:449 → 563
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:995 → 1024
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:691 → 747
    TSP1_ADAMTS; Thrombospondin type 1 domain

  2. NM_144899.3 → NP_659148.2  ADAMTS-like protein 4 precursor

    See identical proteins and their annotated locations for NP_659148.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093317, AI595354, AY158701, BY204619
    Consensus CDS
    CCDS17618.1
    UniProtKB/Swiss-Prot
    Q148X6, Q80T21
    Related
    ENSMUSP00000015994.4, ENSMUST00000015994.4
    Conserved Domains (5) summary
    smart00209
    Location:46 → 70
    TSP1; Thrombospondin type 1 repeats
    PHA03247
    Location:161 → 360
    PHA03247; large tegument protein UL36; Provisional
    pfam05986
    Location:449 → 563
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:995 → 1024
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:691 → 747
    TSP1_ADAMTS; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95583511..95595232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163061.1 → XP_036018954.1  ADAMTS-like protein 4 isoform X2

    Conserved Domains (4) summary
    smart00209
    Location:46 → 70
    TSP1; Thrombospondin type 1 repeats
    PHA03247
    Location:170 → 360
    PHA03247; large tegument protein UL36; Provisional
    pfam05986
    Location:449 → 563
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam19030
    Location:691 → 747
    TSP1_ADAMTS; Thrombospondin type 1 domain

  2. XM_036163059.1 → XP_036018952.1  ADAMTS-like protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q148X6, Q80T21
    Conserved Domains (5) summary
    smart00209
    Location:46 → 70
    TSP1; Thrombospondin type 1 repeats
    PHA03247
    Location:161 → 360
    PHA03247; large tegument protein UL36; Provisional
    pfam05986
    Location:449 → 563
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:995 → 1024
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:691 → 747
    TSP1_ADAMTS; Thrombospondin type 1 domain

  3. XM_036163062.1 → XP_036018955.1  ADAMTS-like protein 4 isoform X3

    Conserved Domains (4) summary
    smart00209
    Location:46 → 70
    TSP1; Thrombospondin type 1 repeats
    PHA03247
    Location:170 → 360
    PHA03247; large tegument protein UL36; Provisional
    pfam05986
    Location:449 → 563
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam19030
    Location:691 → 747
    TSP1_ADAMTS; Thrombospondin type 1 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80T21.1 GenPept UniProtKB/Swiss-Prot:Q80T21

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