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Prune1 prune exopolyphosphatase [ Mus musculus (house mouse) ]

Gene ID: 229589, updated on 21-Apr-2024

Summary

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Official Symbol
Prune1provided by MGI
Official Full Name
prune exopolyphosphataseprovided by MGI
Primary source
MGI:MGI:1925152
See related
Ensembl:ENSMUSG00000015711 AllianceGenome:MGI:1925152
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prune; HTCD37; DRES-17; PRUNEM1; Prune-M1; C130058A12; 9230112O05Rik
Summary
Predicted to enable exopolyphosphatase activity; phosphatase activity; and tubulin binding activity. Predicted to be involved in regulation of microtubule polymerization and regulation of neurogenesis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including exocrine gland; eye; genitourinary system; gut; and nervous system. Orthologous to human PRUNE1 (prune exopolyphosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 23.6), whole brain E14.5 (RPKM 20.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.1; 3 40.74 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95160985..95190817, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95253674..95283506, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 Neighboring gene CDC42 small effector 1 Neighboring gene predicted gene 128 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like Neighboring gene STARR-positive B cell enhancer ABC_E2672 Neighboring gene MINDY lysine 48 deubiquitinase 1 Neighboring gene annexin A9 Neighboring gene STARR-positive B cell enhancer ABC_E9560 Neighboring gene predicted gene, 53243 Neighboring gene ceramide synthase 2 Neighboring gene SET domain, bifurcated 1 Neighboring gene STARR-seq mESC enhancer starr_08380 Neighboring gene predicted gene, 37500

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction. Carotenuto M, et al. Naunyn Schmiedebergs Arch Pharmacol, 2015 Feb. PMID 25138575
  2. NMIHBA results from hypomorphic PRUNE1 variants that lack short-chain exopolyphosphatase activity. Nistala H, et al. Hum Mol Genet, 2021 Jan 6. PMID 33105479, Free PMC Article
  3. Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity. Forus A, et al. Oncogene, 2001 Oct 18. PMID 11687967
  4. Generation of Conditional Knockout Alleles for PRUNE-1. Wu X, et al. Cells, 2023 Feb 6. PMID 36831191, Free PMC Article
  5. PRUNE and NM23-M1 expression in embryonic and adult mouse brain. Carotenuto P, et al. J Bioenerg Biomembr, 2006 Aug. PMID 17033939

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction
    Title: A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables exopolyphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables inorganic diphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables pyrophosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
exopolyphosphatase PRUNE1
Names
protein prune homolog
prune homolog
NP_775482.1
XP_030108440.1
XP_036018950.1
XP_036018951.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173347.2 → NP_775482.1  exopolyphosphatase PRUNE1

    See identical proteins and their annotated locations for NP_775482.1

    Status: PROVISIONAL

    Source sequence(s)
    BC057546
    Consensus CDS
    CCDS17610.1
    UniProtKB/Swiss-Prot
    Q80VU0, Q8BIW1
    Related
    ENSMUSP00000015855.8, ENSMUST00000015855.8
    Conserved Domains (2) summary
    COG1227
    Location:21 → 286
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:218 → 357
    DHHA2; DHHA2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95160985..95190817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252580.1 → XP_030108440.1  exopolyphosphatase PRUNE1 isoform X2

    Conserved Domains (2) summary
    COG1227
    Location:3 → 255
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:187 → 327
    DHHA2; DHHA2 domain

  2. XM_036163058.1 → XP_036018951.1  exopolyphosphatase PRUNE1 isoform X2

    Conserved Domains (2) summary
    COG1227
    Location:3 → 255
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:187 → 327
    DHHA2; DHHA2 domain

  3. XM_036163057.1 → XP_036018950.1  exopolyphosphatase PRUNE1 isoform X1

    Conserved Domains (2) summary
    COG1227
    Location:9 → 274
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:206 → 346
    DHHA2; DHHA2 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BIW1.1 GenPept UniProtKB/Swiss-Prot:Q8BIW1

Gene LinkOut

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