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Gm128 predicted gene 128 [ Mus musculus (house mouse) ]

Gene ID: 229588, updated on 5-Mar-2024

Summary

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Official Symbol
Gm128provided by MGI
Official Full Name
predicted gene 128provided by MGI
Primary source
MGI:MGI:2684974
See related
Ensembl:ENSMUSG00000068860 AllianceGenome:MGI:2684974
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ment; pmis1
Summary
Involved in regulation of cell population proliferation. Predicted to be located in extracellular region. Orthologous to human C1orf56 (chromosome 1 open reading frame 56). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 324.2) See more
Orthologs
human all
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Genomic context

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See Gm128 in Genome Data Viewer
Location:
3 F2.1; 3 40.74 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95144230..95148946, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95236919..95241635, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene GA repeat binding protein, beta 2 Neighboring gene STARR-seq mESC enhancer starr_08372 Neighboring gene predicted gene, 16740 Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 Neighboring gene CDC42 small effector 1 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like Neighboring gene prune exopolyphosphatase Neighboring gene STARR-positive B cell enhancer ABC_E2672 Neighboring gene MINDY lysine 48 deubiquitinase 1 Neighboring gene annexin A9 Neighboring gene STARR-positive B cell enhancer ABC_E9560 Neighboring gene predicted gene, 53243 Neighboring gene ceramide synthase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa. Yamaguchi R, et al. Mol Biol Cell, 2012 Jul. PMID 22621904, Free PMC Article
  2. Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis. Hlady RA, et al. J Clin Invest, 2012 Jan. PMID 22133874, Free PMC Article
  3. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identify Ment (Gm128) as an enhancer of lymphomagenesis that contributes to the tumor suppressor function of Dnmt3b
    Title: Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein MENT
Names
methylated in normal thymocytes protein
protein missing in infertile spermatozoa 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024841.3 → NP_001020012.1  protein MENT precursor

    See identical proteins and their annotated locations for NP_001020012.1

    Status: PROVISIONAL

    Source sequence(s)
    AK144488
    Consensus CDS
    CCDS17608.1
    UniProtKB/Swiss-Prot
    Q569E4
    UniProtKB/TrEMBL
    G9MDF2
    Related
    ENSMUSP00000088324.6, ENSMUST00000090815.6
    Conserved Domains (1) summary
    pfam15322
    Location:36 → 345
    PMSI1; Protein missing in infertile sperm 1, putative

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95144230..95148946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252579.1 → XP_030108439.1  protein MENT isoform X1

    UniProtKB/TrEMBL
    D3YUZ7
    Related
    ENSMUSP00000102815.2, ENSMUST00000107197.2
    Conserved Domains (1) summary
    pfam15322
    Location:36 → 183
    PMSI1; Protein missing in infertile sperm 1, putative
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q569E4.1 GenPept UniProtKB/Swiss-Prot:Q569E4

Gene LinkOut

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