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Isg20l2 interferon stimulated exonuclease gene 20-like 2 [ Mus musculus (house mouse) ]

Gene ID: 229504, updated on 11-Apr-2024

Summary

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Official Symbol
Isg20l2provided by MGI
Official Full Name
interferon stimulated exonuclease gene 20-like 2provided by MGI
Primary source
MGI:MGI:2140076
See related
Ensembl:ENSMUSG00000048039 AllianceGenome:MGI:2140076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930429N24
Summary
Predicted to enable exonuclease activity. Predicted to act upstream of or within ribosome biogenesis. Predicted to be active in nucleus. Is expressed in several structures, including brain ventricular layer; dorsal root ganglion; submandibular gland primordium; thymus primordium; and tooth. Orthologous to human ISG20L2 (interferon stimulated exonuclease gene 20 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 26.3), CNS E11.5 (RPKM 14.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F1; 3 38.78 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87837602..87847994)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87930314..87940686)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08165 Neighboring gene heparin binding growth factor Neighboring gene STARR-positive B cell enhancer ABC_E10190 Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene methyltransferase like 25B Neighboring gene STARR-positive B cell enhancer ABC_E9556 Neighboring gene cellular retinoic acid binding protein II Neighboring gene STARR-positive B cell enhancer ABC_E9216 Neighboring gene predicted gene, 32518

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interferon-stimulated 20 kDa exonuclease-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177663.5 → NP_808331.1  interferon-stimulated 20 kDa exonuclease-like 2

    See identical proteins and their annotated locations for NP_808331.1

    Status: VALIDATED

    Source sequence(s)
    AC158233
    Consensus CDS
    CCDS17459.1
    UniProtKB/Swiss-Prot
    Q3U1G5, Q4KMV7, Q8BKA9
    UniProtKB/TrEMBL
    A0A0R4J0R3
    Related
    ENSMUSP00000059783.7, ENSMUST00000055984.7
    Conserved Domains (1) summary
    cd06149
    Location:195 → 351
    ISG20; DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    87837602..87847994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163048.1 → XP_036018941.1  interferon-stimulated 20 kDa exonuclease-like 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3U1G5, Q4KMV7, Q8BKA9
    UniProtKB/TrEMBL
    A0A0R4J0R3
    Conserved Domains (1) summary
    cd06149
    Location:195 → 351
    ISG20; DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U1G5.2 GenPept UniProtKB/Swiss-Prot:Q3U1G5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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