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Fcrl1 Fc receptor-like 1 [ Mus musculus (house mouse) ]

Gene ID: 229499, updated on 8-May-2024

Summary

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Official Symbol
Fcrl1provided by MGI
Official Full Name
Fc receptor-like 1provided by MGI
Primary source
MGI:MGI:2442862
See related
Ensembl:ENSMUSG00000059994 AllianceGenome:MGI:2442862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bxmh1; Fcrh1; Ifgp1; Bxmas1; Bxmh1b; Fcrh1l; Fcrh1s; A230020G22Rik
Summary
Predicted to enable coreceptor activity and transmembrane signaling receptor activity. Predicted to be involved in B cell activation and cell surface receptor signaling pathway. Predicted to be located in cell surface. Predicted to be integral component of plasma membrane. Orthologous to human FCRL1 (Fc receptor like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 18.8), mammary gland adult (RPKM 4.3) and 1 other tissue See more
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Genomic context

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Location:
3 F1; 3 38.19 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87283656..87311274)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87376353..87403967)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31879 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87127693-87127994 Neighboring gene predicted gene, 31940 Neighboring gene STARR-positive B cell enhancer ABC_E10187 Neighboring gene STARR-positive B cell enhancer ABC_E9215 Neighboring gene CD5 antigen-like Neighboring gene STARR-positive B cell enhancer ABC_E3443 Neighboring gene STARR-seq mESC enhancer starr_08155 Neighboring gene predicted gene, 40084 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87239522-87239823 Neighboring gene Fc receptor-like 5 Neighboring gene STARR-seq mESC enhancer starr_08157 Neighboring gene STARR-seq mESC enhancer starr_08158 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87291959-87292260 Neighboring gene predicted gene, 40085

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in B cell activation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Fc receptor-like protein 1
Names
BXMAS1-like protein 1
BXMAS1-like protein 1b
IFGP family protein 1
fc receptor homolog 1
fcR-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136236.1 → NP_001129708.1  Fc receptor-like protein 1 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in both the 5' and mid coding regions, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AK038494, AK041750
    Consensus CDS
    CCDS50942.1
    UniProtKB/Swiss-Prot
    Q68SP0, Q7TMH2, Q80WN3, Q8BYS4, Q8R4Y0
    UniProtKB/TrEMBL
    E9Q5S9
    Related
    ENSMUSP00000128235.2, ENSMUST00000167200.7
    Conserved Domains (3) summary
    smart00410
    Location:28 → 98
    IG_like; Immunoglobulin like
    pfam00047
    Location:28 → 104
    ig; Immunoglobulin domain
    pfam13927
    Location:116 → 189
    Ig_3; Immunoglobulin domain

  2. NM_001310545.1 → NP_001297474.1  Fc receptor-like protein 1 isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and has multiple coding region differences compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC163618, AK038494, AK041750, BB219508
    Consensus CDS
    CCDS79937.1
    UniProtKB/Swiss-Prot
    Q68SP0, Q7TMH2, Q80WN3, Q8BYS4, Q8R4Y0
    UniProtKB/TrEMBL
    A0A0A6YY56
    Related
    ENSMUSP00000142286.2, ENSMUST00000194786.6
    Conserved Domains (3) summary
    smart00410
    Location:28 → 98
    IG_like; Immunoglobulin like
    pfam13927
    Location:116 → 189
    Ig_3; Immunoglobulin domain
    cl11960
    Location:28 → 104
    Ig; Immunoglobulin domain

  3. NM_153090.2 → NP_694730.2  Fc receptor-like protein 1 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK038494, AK041750
    Consensus CDS
    CCDS50941.1
    UniProtKB/Swiss-Prot
    Q68SP0, Q7TMH2, Q80WN3, Q8BYS4, Q8R4Y0
    UniProtKB/TrEMBL
    E9Q958
    Related
    ENSMUSP00000130936.2, ENSMUST00000163661.8
    Conserved Domains (3) summary
    smart00410
    Location:48 → 118
    IG_like; Immunoglobulin like
    pfam00047
    Location:48 → 124
    ig; Immunoglobulin domain
    pfam13927
    Location:136 → 209
    Ig_3; Immunoglobulin domain

  4. NM_178165.4 → NP_835459.1  Fc receptor-like protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_835459.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AK038494, AK041750
    Consensus CDS
    CCDS17452.1
    UniProtKB/Swiss-Prot
    Q68SP0, Q7TMH2, Q80WN3, Q8BYS4, Q8R4Y0
    UniProtKB/TrEMBL
    A0A0R4J0W8
    Related
    ENSMUSP00000072300.3, ENSMUST00000072480.9
    Conserved Domains (3) summary
    smart00410
    Location:28 → 98
    IG_like; Immunoglobulin like
    pfam13927
    Location:116 → 189
    Ig_3; Immunoglobulin domain
    cl11960
    Location:28 → 104
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    87283656..87311274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501337.4 → XP_006501400.1  Fc receptor-like protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q68SP0, Q7TMH2, Q80WN3, Q8BYS4, Q8R4Y0
    Conserved Domains (2) summary
    smart00409
    Location:1 → 65
    IG; Immunoglobulin
    pfam13927
    Location:84 → 156
    Ig_3; Immunoglobulin domain

  2. XM_017319541.3 → XP_017175030.1  Fc receptor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q68SP0, Q7TMH2, Q80WN3, Q8BYS4, Q8R4Y0
    Conserved Domains (2) summary
    smart00409
    Location:28 → 98
    IG; Immunoglobulin
    pfam13927
    Location:117 → 189
    Ig_3; Immunoglobulin domain

  3. XM_030252566.2 → XP_030108426.1  Fc receptor-like protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q68SP0, Q7TMH2, Q80WN3, Q8BYS4, Q8R4Y0
    Conserved Domains (2) summary
    smart00409
    Location:1 → 65
    IG; Immunoglobulin
    pfam13927
    Location:84 → 156
    Ig_3; Immunoglobulin domain

RNA

  1. XR_001783682.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4Y0.1 GenPept UniProtKB/Swiss-Prot:Q8R4Y0

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