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Gatb glutamyl-tRNA amidotransferase subunit B [ Mus musculus (house mouse) ]

Gene ID: 229487, updated on 11-Apr-2024

Summary

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Official Symbol
Gatbprovided by MGI
Official Full Name
glutamyl-tRNA amidotransferase subunit Bprovided by MGI
Primary source
MGI:MGI:2442496
See related
Ensembl:ENSMUSG00000028085 AllianceGenome:MGI:2442496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pet112; Pet112l; 9430026F02Rik
Summary
Predicted to enable glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Predicted to be involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 41. Orthologous to human GATB (glutamyl-tRNA amidotransferase subunit B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 8.6), heart adult (RPKM 5.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gatb in Genome Data Viewer
Location:
3 F1; 3 37.83 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (85481409..85562945)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (85574102..85655624)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31419 Neighboring gene microRNA 466k Neighboring gene STARR-seq mESC enhancer starr_08109 Neighboring gene predicted gene 3740 Neighboring gene STARR-positive B cell enhancer ABC_E6064 Neighboring gene predicted gene, 54168 Neighboring gene predicted gene, 46809 Neighboring gene STARR-seq mESC enhancer starr_08111 Neighboring gene FHF complex subunit HOOK interacting protein 1A Neighboring gene predicted gene, 40082 Neighboring gene STARR-seq mESC enhancer starr_08112 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Glutamyl-tRNAGln amidotransferase is essential for mammalian mitochondrial translation in vivo. Echevarría L, et al. Biochem J, 2014 May 15. PMID 24579914
  2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC11629

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables carbon-nitrogen ligase activity, with glutamine as amido-N-donor IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutaminyl-tRNAGln biosynthesis via transamidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutaminyl-tRNAGln biosynthesis via transamidation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of glutamyl-tRNA(Gln) amidotransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glutamyl-tRNA(Gln) amidotransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
Names
PET112 homolog
cytochrome c oxidase assembly factor PET112 homolog
cytochrome oxidase assembly factor PET112 homolog
glu-AdT subunit B
glutamyl-tRNA(Gln) amidotransferase, subunit B
probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
NP_001386159.1
NP_659145.1
XP_006501392.1
XP_006501393.1
XP_006501394.1
XP_011238382.1
XP_036018934.1
XP_036018935.1
XP_036018936.1
XP_036018937.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399230.1 → NP_001386159.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102296, AC102338
    UniProtKB/TrEMBL
    Q8BW84
    Related
    ENSMUSP00000103301.2, ENSMUST00000107674.2
    Conserved Domains (1) summary
    PRK05477
    Location:62 → 516
    gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

  2. NM_144896.5 → NP_659145.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_659145.1

    Status: VALIDATED

    Source sequence(s)
    AC102296, AC102338
    Consensus CDS
    CCDS17441.1
    UniProtKB/Swiss-Prot
    Q8BMU3, Q8BUY3, Q99JT1
    UniProtKB/TrEMBL
    Q3TLZ6
    Related
    ENSMUSP00000119949.2, ENSMUST00000127348.8
    Conserved Domains (3) summary
    PRK05477
    Location:62 → 555
    gatB; aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated
    pfam02637
    Location:406 → 555
    GatB_Yqey; GatB domain
    pfam02934
    Location:65 → 351
    GatB_N; GatB/GatE catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    85481409..85562945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501329.3 → XP_006501392.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X1

    Conserved Domains (1) summary
    PRK05477
    Location:62 → 580
    gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

  2. XM_006501330.2 → XP_006501393.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X2

    Conserved Domains (1) summary
    PRK05477
    Location:62 → 620
    gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

  3. XM_036163041.1 → XP_036018934.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X3

    UniProtKB/TrEMBL
    Q3TLZ6
    Conserved Domains (1) summary
    PRK05477
    Location:62 → 575
    gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

  4. XM_006501331.3 → XP_006501394.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X4

    UniProtKB/TrEMBL
    Q3TLZ6
    Conserved Domains (1) summary
    PRK05477
    Location:62 → 515
    gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

  5. XM_036163042.1 → XP_036018935.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X5

    UniProtKB/TrEMBL
    Q3TLZ6
    Conserved Domains (1) summary
    PRK05477
    Location:62 → 510
    gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

  6. XM_036163044.1 → XP_036018937.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X8

    Conserved Domains (1) summary
    PRK05477
    Location:54 → 458
    gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

  7. XM_036163043.1 → XP_036018936.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X7

    Conserved Domains (1) summary
    PRK05477
    Location:54 → 503
    gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

  8. XM_011240080.3 → XP_011238382.1  glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform X6

    Conserved Domains (1) summary
    PRK05477
    Location:54 → 463
    gatB; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB

RNA

  1. XR_375512.3 RNA Sequence

  2. XR_004941305.1 RNA Sequence

  3. XR_003954307.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JT1.1 GenPept UniProtKB/Swiss-Prot:Q99JT1

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