U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gmps guanine monophosphate synthetase [ Mus musculus (house mouse) ]

Gene ID: 229363, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Gmpsprovided by MGI
Official Full Name
guanine monophosphate synthetaseprovided by MGI
Primary source
MGI:MGI:2448526
See related
Ensembl:ENSMUSG00000027823 AllianceGenome:MGI:2448526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
670032; Gm9479
Summary
Enables GMP synthase (glutamine-hydrolyzing) activity. Involved in GMP biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human GMPS (guanine monophosphate synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.1), testis adult (RPKM 10.5) and 25 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3 E1; 3 30.08 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (63871054..63928975)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (63963633..64021554)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130311K13 gene Neighboring gene predicted gene, 34379 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:63768480-63768744 Neighboring gene solute carrier family 33 (acetyl-CoA transporter), member 1 Neighboring gene STARR-positive B cell enhancer ABC_E2666 Neighboring gene STARR-seq mESC enhancer starr_07841 Neighboring gene vomeronasal 2, receptor, pseudogene 3 Neighboring gene vomeronasal 2, receptor 1 Neighboring gene predicted gene, 22165

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Studies with GMP synthetase from Ehrlich ascites cells. Purification, properties, and interactions with nucleotide analogs. Spector T. J Biol Chem, 1975 Sep 25. PMID 240826
  2. Proteomic Analysis Reveals GMP Synthetase as p53 Repression Target in Liver Cancer. Holzer K, et al. Am J Pathol, 2017 Feb. PMID 27939741
  3. Characterization of purine nucleotide metabolism in primary rat muscle cultures. Zoref-Shani E, et al. Biochim Biophys Acta, 1982 Jun 16. PMID 6180773
  4. Interactions of GMP with Human Glrx3 and with Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2 Pathway. Mechoud MA, et al. Appl Environ Microbiol, 2020 Jul 2. PMID 32414791, Free PMC Article
  5. ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease. Cozzolino F, et al. Hum Mol Genet, 2021 Jun 17. PMID 33601422

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GMP synthase (glutamine-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GMP synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GMP synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within GMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GMP salvage ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
GMP synthase [glutamine-hydrolyzing]
Names
GMP synthase
GMP synthetase
glutamine amidotransferase
NP_001028472.2
XP_011238380.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033300.2 → NP_001028472.2  GMP synthase [glutamine-hydrolyzing]

    See identical proteins and their annotated locations for NP_001028472.2

    Status: VALIDATED

    Source sequence(s)
    AK049755, AK136966, AK143197, CN528611
    Consensus CDS
    CCDS17383.1
    UniProtKB/Swiss-Prot
    Q3TFR6, Q3THK7, Q3TIH1, Q3UJ21, Q3V343, Q66JZ6
    UniProtKB/TrEMBL
    B2RRH9
    Related
    ENSMUSP00000029405.8, ENSMUST00000029405.8
    Conserved Domains (3) summary
    cd01742
    Location:28 → 207
    GATase1_GMP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase
    PRK00074
    Location:28 → 693
    guaA; GMP synthase; Reviewed
    cd01997
    Location:238 → 692
    GMP_synthase_C; The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    63871054..63928975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240078.3 → XP_011238380.1  GMP synthase [glutamine-hydrolyzing] isoform X1

    Conserved Domains (1) summary
    PRK00074
    Location:80 → 745
    guaA; GMP synthase; Reviewed
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3THK7.2 GenPept UniProtKB/Swiss-Prot:Q3THK7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous