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Gpr149 G protein-coupled receptor 149 [ Mus musculus (house mouse) ]

Gene ID: 229357, updated on 11-Apr-2024

Summary

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Official Symbol
Gpr149provided by MGI
Official Full Name
G protein-coupled receptor 149provided by MGI
Primary source
MGI:MGI:2443628
See related
Ensembl:ENSMUSG00000043441 AllianceGenome:MGI:2443628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
R35; Ieda; PGR10; 9630018L10Rik
Summary
Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Acts upstream of or within antral ovarian follicle growth; negative regulation of ovulation; and preantral ovarian follicle growth. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Orthologous to human GPR149 (G protein-coupled receptor 149). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 1.6), whole brain E14.5 (RPKM 0.6) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 E1; 3 29.97 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (62436851..62512861, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (62529430..62605440, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07812 Neighboring gene Rho guanine nucleotide exchange factor 26 Neighboring gene predicted gene, 33923 Neighboring gene STARR-seq mESC enhancer starr_07813 Neighboring gene STARR-seq mESC enhancer starr_07814 Neighboring gene DEAH-box helicase 36 Neighboring gene STARR-seq mESC enhancer starr_07815 Neighboring gene STARR-seq mESC enhancer starr_07816 Neighboring gene STARR-seq mESC enhancer starr_07817 Neighboring gene STARR-seq mESC enhancer starr_07818 Neighboring gene mediator of cell motility 1 pseudogene Neighboring gene predicted gene, 40062

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination. Suo N, et al. Glia, 2022 Oct. PMID 35758525
  2. Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice. Edson MA, et al. Endocrinology, 2010 Jan. PMID 19887567, Free PMC Article
  3. Etv1 Controls the Establishment of Non-overlapping Motor Innervation of Neighboring Facial Muscles during Development. Tenney AP, et al. Cell Rep, 2019 Oct 8. PMID 31597102, Free PMC Article
  4. The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning. Kurrasch DM, et al. J Neurosci, 2007 Dec 12. PMID 18077674, Free PMC Article
  5. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gpr149 is involved in energy homeostasis in the male mouse.
    Title: Gpr149 is involved in energy homeostasis in the male mouse.
  2. The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination.
    Title: The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination.
  3. Gpr149 null mice are one of the few models with enhanced fertility.
    Title: Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within antral ovarian follicle growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within estrous cycle phase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of ovulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within preantral ovarian follicle growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 149
Names
G protein-coupled receptor PGR10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356525.1 → NP_001343454.1  probable G-protein coupled receptor 149 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114424, AC115721
    Conserved Domains (1) summary
    cd15011
    Location:37 → 375
    7tmA_GPR149; G protein-coupled receptor 149, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_177346.5 → NP_796320.2  probable G-protein coupled receptor 149 isoform 1

    See identical proteins and their annotated locations for NP_796320.2

    Status: VALIDATED

    Source sequence(s)
    AC114424, AC115721
    Consensus CDS
    CCDS17380.1
    UniProtKB/Swiss-Prot
    Q3TMB1, Q3UVY1, Q80T52, Q8BXA3, Q8BZC0
    Related
    ENSMUSP00000060893.6, ENSMUST00000058535.6
    Conserved Domains (1) summary
    pfam00001
    Location:56 → 211
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    62436851..62512861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240076.3 → XP_011238378.1  probable G-protein coupled receptor 149 isoform X1

    Conserved Domains (1) summary
    cd15011
    Location:37 → 375
    7tmA_GPR149; G protein-coupled receptor 149, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UVY1.1 GenPept UniProtKB/Swiss-Prot:Q3UVY1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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