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Nudt6 nudix hydrolase 6 [ Mus musculus (house mouse) ]

Gene ID: 229228, updated on 5-Mar-2024

Summary

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Official Symbol
Nudt6provided by MGI
Official Full Name
nudix hydrolase 6provided by MGI
Primary source
MGI:MGI:2387618
See related
Ensembl:ENSMUSG00000050174 AllianceGenome:MGI:2387618
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asfgf2b
Summary
Predicted to enable ADP-ribose diphosphatase activity; NAD binding activity; and NADH pyrophosphatase activity. Predicted to be involved in negative regulation of cell cycle and negative regulation of cell population proliferation. Predicted to be located in cytoplasm. Is expressed in brain. Orthologous to human NUDT6 (nudix hydrolase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 10.9), mammary gland adult (RPKM 7.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 B; 3 18.46 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (37459126..37474391, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (37404982..37420242, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene Bardet-Biedl syndrome 12 Neighboring gene 28S ribosomal protein S33, mitochondrial pseudogene Neighboring gene fibroblast growth factor 2, opposite strand Neighboring gene fibroblast growth factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E1616 Neighboring gene AFG2 AAA ATPase homolog A Neighboring gene predicted gene, 36412 Neighboring gene RIKEN cDNA 4930594O21 gene Neighboring gene PRELI domain containing 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Temporal expression analysis of angiogenesis-related genes in brain development. Ozkan A, et al. Vasc Cell, 2012 Oct 1. PMID 23020941, Free PMC Article
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC27904

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP-ribose diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADH pyrophosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nucleoside diphosphate-linked moiety X motif 6
Names
antisense basic fibroblast growth factor B
nudix (nucleoside diphosphate linked moiety X)-type motif 6
nudix motif 6
NP_001277973.1
NP_705789.1
XP_006535522.1
XP_006535523.1
XP_006535525.1
XP_011247972.1
XP_011247973.1
XP_011247974.1
XP_011247976.1
XP_011247977.1
XP_017175028.1
XP_030108418.1
XP_030108419.1
XP_030108420.1
XP_036018924.1
XP_036018925.1
XP_036018926.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291044.1 → NP_001277973.1  nucleoside diphosphate-linked moiety X motif 6 isoform 1

    See identical proteins and their annotated locations for NP_001277973.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL669927
    Consensus CDS
    CCDS71237.1
    UniProtKB/Swiss-Prot
    Q8CH40, Q8R2T3
    UniProtKB/TrEMBL
    Q3ULU4
    Related
    ENSMUSP00000056219.7, ENSMUST00000052645.13
    Conserved Domains (1) summary
    cd04670
    Location:139 → 272
    Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

  2. NM_153561.3 → NP_705789.1  nucleoside diphosphate-linked moiety X motif 6 isoform 2

    See identical proteins and their annotated locations for NP_705789.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL669927
    Consensus CDS
    CCDS38418.1
    UniProtKB/Swiss-Prot
    Q8CH40, Q8R2T3
    UniProtKB/TrEMBL
    A0A0R4J176
    Related
    ENSMUSP00000096733.3, ENSMUST00000099130.9
    Conserved Domains (1) summary
    cd04670
    Location:139 → 271
    Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    37459126..37474391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249671.3 → XP_011247973.1  nucleoside diphosphate-linked moiety X motif 6 isoform X4

    Conserved Domains (2) summary
    cd04670
    Location:71 → 204
    Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
    pfam18290
    Location:8 → 58
    Nudix_hydro; Nudix hydrolase domain

  2. XM_030252560.2 → XP_030108420.1  nucleoside diphosphate-linked moiety X motif 6 isoform X10

    Conserved Domains (1) summary
    cl00447
    Location:10 → 118
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  3. XM_036163033.1 → XP_036018926.1  nucleoside diphosphate-linked moiety X motif 6 isoform X12

    UniProtKB/TrEMBL
    Q8CH41
    Conserved Domains (1) summary
    cl00447
    Location:1 → 106
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  4. XM_030252559.2 → XP_030108419.1  nucleoside diphosphate-linked moiety X motif 6 isoform X10

    Conserved Domains (1) summary
    cl00447
    Location:10 → 118
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  5. XM_006535459.2 → XP_006535522.1  nucleoside diphosphate-linked moiety X motif 6 isoform X3

    Conserved Domains (2) summary
    cd04670
    Location:86 → 219
    Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
    pfam18290
    Location:26 → 73
    Nudix_hydro; Nudix hydrolase domain

  6. XM_006535460.4 → XP_006535523.1  nucleoside diphosphate-linked moiety X motif 6 isoform X10

    Conserved Domains (1) summary
    cl00447
    Location:10 → 118
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  7. XM_006535462.1 → XP_006535525.1  nucleoside diphosphate-linked moiety X motif 6 isoform X12

    See identical proteins and their annotated locations for XP_006535525.1

    UniProtKB/TrEMBL
    Q8CH41
    Related
    ENSMUSP00000142653.2, ENSMUST00000146324.8
    Conserved Domains (1) summary
    cl00447
    Location:1 → 106
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  8. XM_036163032.1 → XP_036018925.1  nucleoside diphosphate-linked moiety X motif 6 isoform X11

    Conserved Domains (1) summary
    cl00447
    Location:10 → 117
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  9. XM_036163031.1 → XP_036018924.1  nucleoside diphosphate-linked moiety X motif 6 isoform X5

    Conserved Domains (2) summary
    cd04670
    Location:71 → 203
    Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
    pfam18290
    Location:8 → 58
    Nudix_hydro; Nudix hydrolase domain

  10. XM_011249670.1 → XP_011247972.1  nucleoside diphosphate-linked moiety X motif 6 isoform X2

    UniProtKB/Swiss-Prot
    Q8CH40, Q8R2T3
    Conserved Domains (2) summary
    pfam18290
    Location:43 → 126
    Nudix_hydro; Nudix hydrolase domain
    cl00447
    Location:142 → 234
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  11. XM_017319539.1 → XP_017175028.1  nucleoside diphosphate-linked moiety X motif 6 isoform X1

    UniProtKB/Swiss-Prot
    Q8CH40, Q8R2T3
    Conserved Domains (2) summary
    pfam18290
    Location:43 → 126
    Nudix_hydro; Nudix hydrolase domain
    cl00447
    Location:146 → 235
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  12. XM_011249675.2 → XP_011247977.1  nucleoside diphosphate-linked moiety X motif 6 isoform X9

    See identical proteins and their annotated locations for XP_011247977.1

    UniProtKB/TrEMBL
    A0A0G2JDN4
    Conserved Domains (1) summary
    pfam18290
    Location:43 → 126
    Nudix_hydro; Nudix hydrolase domain

  13. XM_011249674.1 → XP_011247976.1  nucleoside diphosphate-linked moiety X motif 6 isoform X8

    See identical proteins and their annotated locations for XP_011247976.1

    UniProtKB/TrEMBL
    A0A0G2JDN4
    Conserved Domains (1) summary
    pfam18290
    Location:43 → 126
    Nudix_hydro; Nudix hydrolase domain

  14. XM_011249672.1 → XP_011247974.1  nucleoside diphosphate-linked moiety X motif 6 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JDN4
    Conserved Domains (2) summary
    pfam18290
    Location:43 → 126
    Nudix_hydro; Nudix hydrolase domain
    cl00447
    Location:139 → 181
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  15. XM_030252558.1 → XP_030108418.1  nucleoside diphosphate-linked moiety X motif 6 isoform X7

    UniProtKB/TrEMBL
    A0A0G2JDN4
    Conserved Domains (1) summary
    pfam18290
    Location:43 → 126
    Nudix_hydro; Nudix hydrolase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CH40.1 GenPept UniProtKB/Swiss-Prot:Q8CH40

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