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MSRB2 methionine sulfoxide reductase B2 [ Homo sapiens (human) ]

Gene ID: 22921, updated on 7-Apr-2024

Summary

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Official Symbol
MSRB2provided by HGNC
Official Full Name
methionine sulfoxide reductase B2provided by HGNC
Primary source
HGNC:HGNC:17061
See related
Ensembl:ENSG00000148450 MIM:613782; AllianceGenome:HGNC:17061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBS1; MSRB; PILB; CBS-1; CGI-131
Summary
Predicted to enable actin binding activity; peptide-methionine (R)-S-oxide reductase activity; and zinc ion binding activity. Predicted to be involved in actin filament polymerization and protein repair. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart (RPKM 17.2), liver (RPKM 8.9) and 24 other tissues See more
Orthologs
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Genomic context

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See MSRB2 in Genome Data Viewer
Location:
10p12.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (23095579..23122013)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (23114573..23140973)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (23384508..23410942)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376451 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:23164275-23164885 Neighboring gene armadillo repeat containing 3 Neighboring gene uncharacterized LOC107984215 Neighboring gene RNA, 5S ribosomal pseudogene 304 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:23341078-23341578 Neighboring gene NANOG hESC enhancer GRCh37_chr10:23344706-23345245 Neighboring gene Sharpr-MPRA regulatory region 11378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3149 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3150 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta pseudogene 3 Neighboring gene uncharacterized LOC124900299

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Overexpression of mitochondrial methionine sulfoxide reductase B2 protects leukemia cells from oxidative stress-induced cell death and protein damage. Cabreiro F, et al. J Biol Chem, 2008 Jun 13. PMID 18424444
  2. A second human methionine sulfoxide reductase (hMSRB2) reducing methionine-R-sulfoxide displays a tissue expression pattern distinct from hMSRB1. Hansel A, et al. Redox Rep, 2003. PMID 14980072
  3. Activity, tissue distribution and site-directed mutagenesis of a human peptide methionine sulfoxide reductase of type B: hCBS1. Jung S, et al. FEBS Lett, 2002 Sep 11. PMID 12220640
  4. Mitochondrial methionine sulfoxide reductase B2 links oxidative stress to Alzheimer's disease-like pathology. Xiang XJ, et al. Exp Neurol, 2019 Aug. PMID 31078523
  5. Identification of activators of methionine sulfoxide reductases A and B. Cudic P, et al. Biochem Biophys Res Commun, 2016 Jan 22. PMID 26718410, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Release of the enzyme MsrB2 from damaged mitochondria, initiating autophagosome formation, represents a novel regulatory mechanism for oxidative stress-induced mitophagy.
    Title: Mitochondrial MsrB2 serves as a switch and transducer for mitophagy.
  2. the role for mitochondrial MSRB2 in Alzheimer's disease pathology is indispensible.
    Title: Mitochondrial methionine sulfoxide reductase B2 links oxidative stress to Alzheimer's disease-like pathology.
  3. this study we have identified, for the first time, compounds structurally related to the natural products fusaricidins that markedly activate recombinant bovine and human MsrA and human MsrB.
    Title: Identification of activators of methionine sulfoxide reductases A and B.
  4. Silencing the expression of the main Msr elements-MsrA, MsrB1, or MsrB2 exacerbates sensitivity toward oxidative stress.
    Title: Proteome alteration in oxidative stress-sensitive methionine sulfoxide reductase-silenced HEK293 cells.
  5. the mitochondrial methionine-R-sulfoxide reductase B2 (MSRB2) is a specific interaction partner of LG72.
    Title: Identification of the mitochondrial MSRB2 as a binding partner of LG72.
  6. Data show that glutaredoxin acts as a reductant for methionine sulfoxide reductases A and B (MsrA and MsrB) with or without resolving cysteine.
    Title: Glutaredoxin serves as a reductant for methionine sulfoxide reductases with or without resolving cysteine.
  7. MSR enzymes are differentially expressed in human skin.
    Title: Differential expression of the antioxidant repair enzyme methionine sulfoxide reductase (MSRA and MSRB) in human skin.
  8. almost absent catalase and methionine sulfoxide reductase A and B protein expression in human gray/white scalp hair shafts in association with a functional loss of methionine sulfoxide repair in the entire gray hair follicle
    Title: Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
  10. upon oxidative stress, the overexpression of methionine sulfoxide reductase B2 leads to the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role
    Title: Overexpression of mitochondrial methionine sulfoxide reductase B2 protects leukemia cells from oxidative stress-induced cell death and protein damage.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC26104

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-methionine-(R)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptide-methionine (R)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-methionine (R)-S-oxide reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables peptide-methionine (R)-S-oxide reductase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein repair ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein repair TAS
Traceable Author Statement
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
methionine-R-sulfoxide reductase B2, mitochondrial
Names
pilin-like transcription factor
NP_036360.3
XP_011517728.1
XP_054221207.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012228.4 → NP_036360.3  methionine-R-sulfoxide reductase B2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_036360.3

    Status: VALIDATED

    Source sequence(s)
    AF151889, AL139281, BC117471
    Consensus CDS
    CCDS41495.1
    UniProtKB/Swiss-Prot
    Q17R44, Q4G1C7, Q9Y3D2, Q9Y5W6
    Related
    ENSP00000365693.3, ENST00000376510.8
    Conserved Domains (1) summary
    pfam01641
    Location:53 → 179
    SelR; SelR domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    23095579..23122013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519426.3 → XP_011517728.1  methionine-R-sulfoxide reductase B2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A6NCQ5
    Conserved Domains (1) summary
    cl15841
    Location:51 → 100
    SelR; SelR domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    23114573..23140973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365232.1 → XP_054221207.1  methionine-R-sulfoxide reductase B2, mitochondrial isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y3D2.2 GenPept UniProtKB/Swiss-Prot:Q9Y3D2

Gene LinkOut

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