U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Taf4 TATA-box binding protein associated factor 4 [ Mus musculus (house mouse) ]

Gene ID: 228980, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Taf4provided by MGI
Official Full Name
TATA-box binding protein associated factor 4provided by MGI
Primary source
MGI:MGI:2152346
See related
Ensembl:ENSMUSG00000039117 AllianceGenome:MGI:2152346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Taf4a; 135kDa; Taf2c1; TAFII130; TAFII135
Summary
Enables DNA binding activity. Acts upstream of or within ovarian follicle development and transcription, DNA-templated. Located in nucleus. Is expressed in brain; spinal cord; tail; and thymus. Orthologous to human TAF4 (TATA-box binding protein associated factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 9.9), colon adult (RPKM 7.4) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2 H4; 2 102.42 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179553945..179618519, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (179912146..179976646, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 36004 Neighboring gene cadherin 4 Neighboring gene STARR-seq mESC enhancer starr_06718 Neighboring gene STARR-seq mESC enhancer starr_06719 Neighboring gene STARR-seq mESC enhancer starr_06720 Neighboring gene STARR-seq mESC enhancer starr_06721 Neighboring gene STARR-seq mESC enhancer starr_06722 Neighboring gene predicted gene, 36066 Neighboring gene STARR-seq mESC enhancer starr_06724 Neighboring gene RIKEN cDNA 4921531C22 gene Neighboring gene STARR-seq mESC enhancer starr_06725 Neighboring gene STARR-positive B cell enhancer ABC_E7896 Neighboring gene LSM family member 14B

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Single cell transcriptomics reveal trans-differentiation of pancreatic beta cells following inactivation of the TFIID subunit Taf4. Kleiber T, et al. Cell Death Dis, 2021 Aug 12. PMID 34385420, Free PMC Article
  2. A TAF4 coactivator function for E proteins that involves enhanced TFIID binding. Chen WY, et al. Genes Dev, 2013 Jul 15. PMID 23873942, Free PMC Article
  3. The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis. Fadloun A, et al. Development, 2007 Aug. PMID 17626060
  4. TAF4 inactivation in embryonic fibroblasts activates TGF beta signalling and autocrine growth. Mengus G, et al. EMBO J, 2005 Aug 3. PMID 16015375, Free PMC Article
  5. A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia. Xu Y, et al. Cancer Cell, 2018 Jan 8. PMID 29316427, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Single cell transcriptomics reveal trans-differentiation of pancreatic beta cells following inactivation of the TFIID subunit Taf4.
    Title: Single cell transcriptomics reveal trans-differentiation of pancreatic beta cells following inactivation of the TFIID subunit Taf4.
  2. Ectopic expression of the TAF4 histone-fold fragment can efficiently squelch TAF12 in cells
    Title: A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia.
  3. Local promoter-proximal HNF4A-TFIID interactions therefore act as instructive signals for post-natal hepatocyte differentiation.
    Title: TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.
  4. Data show that the TFIID subunit TAF4 is essential to restrain the growth promoting properties of collagen 6A3 (Col6a3).
    Title: TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3.
  5. A role for TAF4 as a cofactor in the cellular response to trans retinoic acid.
    Title: Retinoic acid induces TGFbeta-dependent autocrine fibroblast growth.
  6. TAF4 is an important regulator of keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity.
    Title: The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables aryl hydrocarbon receptor binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in DNA-templated transcription initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of transcription factor TFTC complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
transcription initiation factor TFIID subunit 4
Names
TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor
TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kd

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081092.2 → NP_001074561.1  transcription initiation factor TFIID subunit 4

    Status: VALIDATED

    Source sequence(s)
    AL663067
    Consensus CDS
    CCDS38373.1
    UniProtKB/TrEMBL
    E9QAP7
    Related
    ENSMUSP00000038610.8, ENSMUST00000041618.13
    Conserved Domains (2) summary
    pfam05236
    Location:791 → 1039
    TAF4; Transcription initiation factor TFIID component TAF4 family
    pfam07531
    Location:550 → 633
    TAFH; NHR1 homology to TAF

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    179553945..179618519 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500588.2 → XP_006500651.2  transcription initiation factor TFIID subunit 4 isoform X1

    UniProtKB/TrEMBL
    A0A2I3BPN6
    Related
    ENSMUSP00000153863.2, ENSMUST00000227325.2
    Conserved Domains (2) summary
    pfam05236
    Location:779 → 1027
    TAF4; Transcription initiation factor TFIID component TAF4 family
    pfam07531
    Location:550 → 633
    TAFH; NHR1 homology to TAF

RNA

  1. XR_004940192.1 RNA Sequence

  2. XR_004940194.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous