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Tshz2 teashirt zinc finger family member 2 [ Mus musculus (house mouse) ]

Gene ID: 228911, updated on 21-Apr-2024

Summary

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Official Symbol
Tshz2provided by MGI
Official Full Name
teashirt zinc finger family member 2provided by MGI
Primary source
MGI:MGI:2153084
See related
Ensembl:ENSMUSG00000047907 AllianceGenome:MGI:2153084
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tsh2; Mtsh2; Zfp218; Sdccag33l; mKIAA4248; teashirt2; B830045G17; 2900073F20Rik
Summary
Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within regulation of gene expression. Predicted to be active in nucleus. Is expressed in several structures, including forelimb; genitourinary system; hindgut; limb bud; and vibrissa. Orthologous to human TSHZ2 (teashirt zinc finger homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 8.3), bladder adult (RPKM 7.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H3; 2 89.47 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (169474430..169914671)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (169632509..170072751)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 34112 Neighboring gene predicted gene 14249 Neighboring gene STARR-seq mESC enhancer starr_06491 Neighboring gene VISTA enhancer mm1064 Neighboring gene predicted gene, 34294 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:169520657-169520858 Neighboring gene predicted gene, 34344 Neighboring gene STARR-seq mESC enhancer starr_06492 Neighboring gene predicted gene, 54131 Neighboring gene STARR-seq mESC enhancer starr_06495 Neighboring gene STARR-seq mESC enhancer starr_06496 Neighboring gene STARR-seq mESC enhancer starr_06499 Neighboring gene STARR-seq mESC enhancer starr_06500 Neighboring gene STARR-seq mESC enhancer starr_06501 Neighboring gene cDNA sequence AY702102 Neighboring gene STARR-seq mESC enhancer starr_06502 Neighboring gene STARR-seq mESC enhancer starr_06503 Neighboring gene RIKEN cDNA A630075F10 gene Neighboring gene STARR-positive B cell enhancer ABC_E6026 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:169978978-169979087 Neighboring gene STARR-positive B cell enhancer ABC_E9210 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:169980510-169980753 Neighboring gene STARR-positive B cell enhancer ABC_E10165 Neighboring gene STARR-positive B cell enhancer ABC_E2658 Neighboring gene zinc finger protein 217 Neighboring gene predicted gene, 34403

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression and regulation of mouse Mtsh1 during limb and branchial arch development. Long Q, et al. Dev Dyn, 2001 Oct. PMID 11668608
  2. Vertebrate orthologues of the Drosophila region-specific patterning gene teashirt. Caubit X, et al. Mech Dev, 2000 Mar 1. PMID 10704881
  3. Teashirt 3 expression in the chick embryo reveals a remarkable association with tendon development. Manfroid I, et al. Gene Expr Patterns, 2006 Oct. PMID 16631416
  4. Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction. Jenkins D, et al. Nephrol Dial Transplant, 2010 Jan. PMID 19745106
  5. Three putative murine Teashirt orthologues specify trunk structures in Drosophila in the same way as the Drosophila teashirt gene. Manfroid I, et al. Development, 2004 Mar. PMID 14973285

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tshz2 and Tshz3 genes were detected in mouse ureters.
    Title: Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction.
  2. role for mTsh genes in the establishment of regional identity and specification of cell types in the developing and adult forebrain
    Title: Expression patterns of the three Teashirt-related genes define specific boundaries in the developing and postnatal mouse forebrain.
  3. three mouse Tsh genes are functionally equivalent to the Drosophila tsh gene when expressed in developing Drosophila embryos
    Title: Three putative murine Teashirt orthologues specify trunk structures in Drosophila in the same way as the Drosophila teashirt gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transposon induced (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4248

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
teashirt homolog 2
Names
SDCCAG33-like protein
serologically defined colon cancer antigen 33 like
teashirt 2
zinc finger protein 218

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363022.2 → NP_001349951.1  teashirt homolog 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AL731822, AL731826
    Consensus CDS
    CCDS50805.1
    UniProtKB/Swiss-Prot
    Q5DTF1, Q68FE9, Q6AXH5, Q9JL71
    Conserved Domains (1) summary
    cd00086
    Location:838 → 906
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  2. NM_001363023.2 → NP_001349952.1  teashirt homolog 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AL731822, AL731826
    Consensus CDS
    CCDS50805.1
    UniProtKB/Swiss-Prot
    Q5DTF1, Q68FE9, Q6AXH5, Q9JL71
    Related
    ENSMUSP00000104787.3, ENSMUST00000109159.3
    Conserved Domains (1) summary
    cd00086
    Location:838 → 906
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  3. NM_080455.4 → NP_536703.2  teashirt homolog 2 isoform a

    See identical proteins and their annotated locations for NP_536703.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AL731822, AL731826
    Consensus CDS
    CCDS50805.1
    UniProtKB/Swiss-Prot
    Q5DTF1, Q68FE9, Q6AXH5, Q9JL71
    Related
    ENSMUSP00000104785.2, ENSMUST00000109157.2
    Conserved Domains (1) summary
    cd00086
    Location:838 → 906
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  4. NM_177659.2 → NP_808327.1  teashirt homolog 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction in the 3' end compared to variant 1. The resulting isoform (b) is shorter at the C-terminus compared to isoform a.
    Source sequence(s)
    AL731822, AL731826
    Conserved Domains (2) summary
    cd00086
    Location:838 → 906
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:218 → 240
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    169474430..169914671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161701.1 → XP_036017594.1  teashirt homolog 2 isoform X4

    Conserved Domains (2) summary
    cd00086
    Location:838 → 906
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:218 → 240
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_006499424.5 → XP_006499487.2  teashirt homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006499487.2

    Conserved Domains (2) summary
    cd00086
    Location:858 → 926
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:238 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_006499426.5 → XP_006499489.2  teashirt homolog 2 isoform X3

    See identical proteins and their annotated locations for XP_006499489.2

    Conserved Domains (2) summary
    cd00086
    Location:858 → 926
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:238 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_006499423.5 → XP_006499486.2  teashirt homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006499486.2

    Conserved Domains (2) summary
    cd00086
    Location:858 → 926
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:238 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_006499425.5 → XP_006499488.2  teashirt homolog 2 isoform X2

    See identical proteins and their annotated locations for XP_006499488.2

    Conserved Domains (2) summary
    cd00086
    Location:858 → 926
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:238 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_030250745.2 → XP_030106605.1  teashirt homolog 2 isoform X1

    Conserved Domains (2) summary
    cd00086
    Location:858 → 926
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:238 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FE9.1 GenPept UniProtKB/Swiss-Prot:Q68FE9

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