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Zfp334 zinc finger protein 334 [ Mus musculus (house mouse) ]

Gene ID: 228876, updated on 30-Apr-2024

Summary

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Official Symbol
Zfp334provided by MGI
Official Full Name
zinc finger protein 334provided by MGI
Primary source
MGI:MGI:2388656
See related
Ensembl:ENSMUSG00000017667 AllianceGenome:MGI:2388656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D2Ertd535e
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; brain; eye; genitourinary system; and spinal cord. Orthologous to human ZNF334 (zinc finger protein 334). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 11.8), whole brain E14.5 (RPKM 7.8) and 21 other tissues See more
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Genomic context

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Location:
2 H3; 2 85.53 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165216184..165230234, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165374264..165388315, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene engulfment and cell motility 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:165147221-165147404 Neighboring gene STARR-positive B cell enhancer ABC_E418 Neighboring gene zinc finger protein 663 Neighboring gene STARR-seq mESC enhancer starr_06348 Neighboring gene predicted gene, 29831 Neighboring gene osteoclast stimulatory transmembrane protein Neighboring gene solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 Neighboring gene origin of replication near adenosine deaminase Neighboring gene predicted gene 14437

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC27911

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 334

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178411.3 → NP_848498.2  zinc finger protein 334

    See identical proteins and their annotated locations for NP_848498.2

    Status: VALIDATED

    Source sequence(s)
    AL591064
    Consensus CDS
    CCDS17079.1
    UniProtKB/TrEMBL
    A2A4U6, Q8CGF0
    Related
    ENSMUSP00000099373.4, ENSMUST00000103084.4
    Conserved Domains (3) summary
    smart00349
    Location:9 → 68
    KRAB; krueppel associated box
    COG5048
    Location:262 → 678
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238 → 258
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    165216184..165230234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161641.1 → XP_036017534.1  zinc finger protein 334 isoform X4

    UniProtKB/TrEMBL
    Q8CGF0
    Conserved Domains (3) summary
    smart00349
    Location:9 → 68
    KRAB; krueppel associated box
    COG5048
    Location:261 → 677
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:237 → 257
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_036161639.1 → XP_036017532.1  zinc finger protein 334 isoform X1

    UniProtKB/TrEMBL
    Q8CGF0
    Conserved Domains (3) summary
    smart00349
    Location:20 → 79
    KRAB; krueppel associated box
    COG5048
    Location:273 → 689
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:249 → 269
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_011239500.3 → XP_011237802.1  zinc finger protein 334 isoform X2

    UniProtKB/TrEMBL
    Q8CGF0
    Conserved Domains (3) summary
    smart00349
    Location:20 → 79
    KRAB; krueppel associated box
    COG5048
    Location:272 → 688
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:248 → 268
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_006499377.5 → XP_006499440.1  zinc finger protein 334 isoform X1

    UniProtKB/TrEMBL
    Q8CGF0
    Conserved Domains (3) summary
    smart00349
    Location:20 → 79
    KRAB; krueppel associated box
    COG5048
    Location:273 → 689
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:249 → 269
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_036161640.1 → XP_036017533.1  zinc finger protein 334 isoform X3

    UniProtKB/TrEMBL
    A2A4U6, Q8CGF0
    Conserved Domains (3) summary
    smart00349
    Location:9 → 68
    KRAB; krueppel associated box
    COG5048
    Location:262 → 678
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238 → 258
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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