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Ncoa5 nuclear receptor coactivator 5 [ Mus musculus (house mouse) ]

Gene ID: 228869, updated on 5-Mar-2024

Summary

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Official Symbol
Ncoa5provided by MGI
Official Full Name
nuclear receptor coactivator 5provided by MGI
Primary source
MGI:MGI:2385165
See related
Ensembl:ENSMUSG00000039804 AllianceGenome:MGI:2385165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CIA
Summary
Enables chromatin binding activity. Acts upstream of or within glucose homeostasis and negative regulation of insulin receptor signaling pathway. Predicted to be located in actin cytoskeleton and nucleoplasm. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Orthologous to human NCOA5 (nuclear receptor coactivator 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 28.4), CNS E18 (RPKM 25.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H3; 2 85.32 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164842273..164876794, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165000353..165034871, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164768440-164768694 Neighboring gene matrix metallopeptidase 9 Neighboring gene solute carrier family 12, member 5 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06346 Neighboring gene STARR-positive B cell enhancer ABC_E2060 Neighboring gene STARR-positive B cell enhancer ABC_E4518 Neighboring gene CD40 antigen Neighboring gene RIKEN cDNA 1700025C18 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NCOA5 deficiency promotes a unique liver protumorigenic microenvironment through p21(WAF1/CIP1) overexpression, which is reversed by metformin. Williams M, et al. Oncogene, 2020 May. PMID 32203160, Free PMC Article
  2. NCOA5 Haplo-insufficiency Results in Male Mouse Infertility through Increased IL-6 Expression in the Epididymis. Gao S, et al. Sci Rep, 2019 Oct 29. PMID 31664153, Free PMC Article
  3. An LXR-NCOA5 gene regulatory complex directs inflammatory crosstalk-dependent repression of macrophage cholesterol efflux. Gillespie MA, et al. EMBO J, 2015 May 5. PMID 25755249, Free PMC Article
  4. CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant. Sauvé F, et al. Mol Cell Biol, 2001 Jan. PMID 11113208, Free PMC Article
  5. NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma. Gao S, et al. Cancer Cell, 2013 Dec 9. PMID 24332041, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NCOA5 Haploinsufficiency in Myeloid-Lineage Cells Sufficiently Causes Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma.
    Title: NCOA5 Haploinsufficiency in Myeloid-Lineage Cells Sufficiently Causes Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma.
  2. NCOA5 deficiency promotes a unique liver protumorigenic microenvironment through p21(WAF1/CIP1) overexpression, which is reversed by metformin.
    Title: NCOA5 deficiency promotes a unique liver protumorigenic microenvironment through p21(WAF1/CIP1) overexpression, which is reversed by metformin.
  3. NCOA5 functions as an LXR corepressor.A central role for NCOA5 in mediating crosstalk between pro-inflammatory and anti-inflammatory pathways that results in repression of macrophage cholesterol efflux.
    Title: An LXR-NCOA5 gene regulatory complex directs inflammatory crosstalk-dependent repression of macrophage cholesterol efflux.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28864

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within glucose homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear receptor coactivator 5
Names
NCoA-5
coactivator independent of AF-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144892.1 → NP_659141.1  nuclear receptor coactivator 5

    See identical proteins and their annotated locations for NP_659141.1

    Status: VALIDATED

    Source sequence(s)
    BC017152
    Consensus CDS
    CCDS17068.1
    UniProtKB/Swiss-Prot
    A2A5L2, Q91W39
    Related
    ENSMUSP00000046388.9, ENSMUST00000040381.15
    Conserved Domains (2) summary
    COG0124
    Location:186 → 256
    HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    PRK14971
    Location:459 → 543
    PRK14971; DNA polymerase III subunits gamma and tau; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164842273..164876794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499369.5 → XP_006499432.2  nuclear receptor coactivator 5 isoform X1

    UniProtKB/TrEMBL
    B7ZC24
    Related
    ENSMUSP00000113166.2, ENSMUST00000122070.2
    Conserved Domains (1) summary
    COG0124
    Location:186 → 256
    HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

  2. XM_030250665.1 → XP_030106525.1  nuclear receptor coactivator 5 isoform X3

    UniProtKB/TrEMBL
    B7ZC23

  3. XM_036161618.1 → XP_036017511.1  nuclear receptor coactivator 5 isoform X3

    UniProtKB/TrEMBL
    B7ZC23

  4. XM_017317897.2 → XP_017173386.1  nuclear receptor coactivator 5 isoform X2

    UniProtKB/TrEMBL
    Q8BX12
    Conserved Domains (1) summary
    COG0124
    Location:38 → 108
    HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91W39.1 GenPept UniProtKB/Swiss-Prot:Q91W39

Gene LinkOut

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