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Ralgapb Ral GTPase activating protein, beta subunit (non-catalytic) [ Mus musculus (house mouse) ]

Gene ID: 228850, updated on 21-Apr-2024

Summary

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Official Symbol
Ralgapbprovided by MGI
Official Full Name
Ral GTPase activating protein, beta subunit (non-catalytic)provided by MGI
Primary source
MGI:MGI:2444531
See related
Ensembl:ENSMUSG00000027652 AllianceGenome:MGI:2444531
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p170; B230339M05Rik
Summary
Enables GTPase activator activity. Acts upstream of or within several processes, including Ral protein signal transduction; activation of GTPase activity; and regulation of exocyst localization. Predicted to be located in cytosol. Is expressed in central nervous system and retina. Orthologous to human RALGAPB (Ral GTPase activating protein non-catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 10.3), whole brain E14.5 (RPKM 9.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H1; 2 78.72 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (158251722..158341173)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (158409830..158499253)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7878 Neighboring gene small nucleolar RNA host gene 11 Neighboring gene predicted gene, 25187 Neighboring gene predicted gene, 25129 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:158235029-158235212 Neighboring gene STARR-seq mESC enhancer starr_06233 Neighboring gene predicted gene 14200 Neighboring gene predicted gene, 54127 Neighboring gene adipogenin Neighboring gene Rho GTPase activating protein 40

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RalA controls glucose homeostasis by regulating glucose uptake in brown fat. Skorobogatko Y, et al. Proc Natl Acad Sci U S A, 2018 Jul 24. PMID 29915037, Free PMC Article
  2. A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Chen XW, et al. Mol Biol Cell, 2011 Jan 1. PMID 21148297, Free PMC Article
  3. Annotation and analysis of 10,000 expressed sequence tags from developing mouse eye and adult retina. Yu J, et al. Genome Biol, 2003. PMID 14519200, Free PMC Article
  4. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
  5. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1219, 9330195P16

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Ral protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within activation of GTPase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of exocyst localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
ral GTPase-activating protein subunit beta
Names
ral GTPase-activating protein beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291137.1 → NP_001278066.1  ral GTPase-activating protein subunit beta isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AI836674, AL663091, AL844513, CJ119771
    Consensus CDS
    CCDS71178.1
    UniProtKB/TrEMBL
    B2RRF1, E9Q0J2
    Related
    ENSMUSP00000105111.3, ENSMUST00000109485.9
    Conserved Domains (1) summary
    pfam10428
    Location:354 → 427
    SOG2; RAM signalling pathway protein

  2. NM_001291138.1 → NP_001278067.1  ral GTPase-activating protein subunit beta isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AI836674, AL663091, AL844513, CJ119771
    Consensus CDS
    CCDS71179.1
    UniProtKB/TrEMBL
    A2ACC6, B2RRF1
    Related
    ENSMUSP00000105112.3, ENSMUST00000109486.9
    Conserved Domains (1) summary
    pfam10428
    Location:354 → 427
    SOG2; RAM signalling pathway protein

  3. NM_001363006.1 → NP_001349935.1  ral GTPase-activating protein subunit beta isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL663091, AL844513
    UniProtKB/TrEMBL
    B2RRF1

  4. NM_001369183.1 → NP_001356112.1  ral GTPase-activating protein subunit beta isoform d

    Status: VALIDATED

    Source sequence(s)
    AL663091, AL844513
    UniProtKB/TrEMBL
    A2ACC7
    Related
    ENSMUSP00000116481.2, ENSMUST00000141497.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    158251722..158341173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499359.5 → XP_006499422.1  ral GTPase-activating protein subunit beta isoform X2

    UniProtKB/TrEMBL
    B2RRF1
    Conserved Domains (1) summary
    pfam10428
    Location:354 → 427
    SOG2; RAM signalling pathway protein

  2. XM_006499361.5 → XP_006499424.1  ral GTPase-activating protein subunit beta isoform X3

    UniProtKB/TrEMBL
    B2RRF1
    Conserved Domains (1) summary
    pfam10428
    Location:354 → 427
    SOG2; RAM signalling pathway protein

  3. XM_006499357.5 → XP_006499420.1  ral GTPase-activating protein subunit beta isoform X1

    See identical proteins and their annotated locations for XP_006499420.1

    UniProtKB/TrEMBL
    B2RRF1
    Conserved Domains (1) summary
    pfam10428
    Location:354 → 427
    SOG2; RAM signalling pathway protein

  4. XM_006499363.5 → XP_006499426.1  ral GTPase-activating protein subunit beta isoform X5

    UniProtKB/TrEMBL
    B2RRF1
    Conserved Domains (1) summary
    pfam10428
    Location:354 → 427
    SOG2; RAM signalling pathway protein

  5. XM_036161598.1 → XP_036017491.1  ral GTPase-activating protein subunit beta isoform X7

    UniProtKB/TrEMBL
    B2RRF1

  6. XM_006499362.5 → XP_006499425.1  ral GTPase-activating protein subunit beta isoform X4

    UniProtKB/TrEMBL
    B2RRF1
    Conserved Domains (1) summary
    pfam10428
    Location:354 → 427
    SOG2; RAM signalling pathway protein

  7. XM_011239490.4 → XP_011237792.1  ral GTPase-activating protein subunit beta isoform X6

    UniProtKB/TrEMBL
    B2RRF1, F8WHN4
    Related
    ENSMUSP00000048430.6, ENSMUST00000046274.12
    Conserved Domains (1) summary
    pfam10428
    Location:354 → 427
    SOG2; RAM signalling pathway protein

  8. XM_011239491.4 → XP_011237793.1  ral GTPase-activating protein subunit beta isoform X9

    Conserved Domains (1) summary
    pfam10428
    Location:354 → 427
    SOG2; RAM signalling pathway protein

  9. XM_017317885.3 → XP_017173374.1  ral GTPase-activating protein subunit beta isoform X8

    UniProtKB/TrEMBL
    B2RRF1

  10. XM_006499358.2 → XP_006499421.1  ral GTPase-activating protein subunit beta isoform X1

    See identical proteins and their annotated locations for XP_006499421.1

    UniProtKB/TrEMBL
    B2RRF1
    Conserved Domains (1) summary
    pfam10428
    Location:354 → 427
    SOG2; RAM signalling pathway protein

RNA

  1. XR_004940148.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177227.2: Suppressed sequence

    Description
    NM_177227.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_177658.3: Suppressed sequence

    Description
    NM_177658.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BQZ4.2 GenPept UniProtKB/Swiss-Prot:Q8BQZ4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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