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Tgif2 TGFB-induced factor homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 228839, updated on 11-Apr-2024

Summary

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Official Symbol
Tgif2provided by MGI
Official Full Name
TGFB-induced factor homeobox 2provided by MGI
Primary source
MGI:MGI:1915299
See related
Ensembl:ENSMUSG00000062175 AllianceGenome:MGI:1915299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921501K24; 5730599O09Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including nodal signaling pathway; positive regulation of neuron differentiation; and regulation of gastrulation. Predicted to be located in centrosome and nucleoplasm. Is expressed in several structures, including alimentary system; brain; forelimb phalanx; genitourinary system; and sensory organ. Orthologous to several human genes including TGIF2-RAB5IF (TGIF2-RAB5IF readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 11.1), limb E14.5 (RPKM 10.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H1; 2 77.86 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156681737..156697490)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156839817..156855570)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06181 Neighboring gene myosin, light polypeptide 9, regulatory Neighboring gene STARR-seq mESC enhancer starr_06182 Neighboring gene ribosomal protein L9 pseudogene Neighboring gene VISTA enhancer mm1377 Neighboring gene predicted gene 14230 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156665530-156665639 Neighboring gene RIKEN cDNA 5430405H02 gene Neighboring gene STARR-positive B cell enhancer ABC_E1606 Neighboring gene RAB5 interacting factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156712828-156713029 Neighboring gene Src-like-adaptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Downregulation of TGIF2 is possibly correlated with neuronal apoptosis and autism-like symptoms in mice. Lei J, et al. Brain Behav, 2022 Jun. PMID 35592894, Free PMC Article
  2. TGFβ-induced factor homeobox 2 blocks osteoblastic differentiation through targeting pSmad3/HDAC4/H4ac/Runx2 axis. Yu X, et al. J Cell Physiol, 2019 Nov. PMID 31066043
  3. Circular RNA circCPA4 promotes tumorigenesis by regulating miR-214-3p/TGIF2 in lung cancer. Tao W, et al. Thorac Cancer, 2021 Dec. PMID 34741437, Free PMC Article
  4. The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm. Spagnoli FM, et al. Development, 2008 Feb. PMID 18094028
  5. The Tgif2 gene contains a retained intron within the coding sequence. Melhuish TA, et al. BMC Mol Biol, 2006 Jan 25. PMID 16436215, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of TGIF2 is possibly correlated with neuronal apoptosis and autism-like symptoms in mice.
    Title: Downregulation of TGIF2 is possibly correlated with neuronal apoptosis and autism-like symptoms in mice.
  2. Circular RNA circCPA4 promotes tumorigenesis by regulating miR-214-3p/TGIF2 in lung cancer.
    Title: Circular RNA circCPA4 promotes tumorigenesis by regulating miR-214-3p/TGIF2 in lung cancer.
  3. Gm14230 safeguards cellular juvenescence through recruiting the histone methyltransferase Ezh2 to Tgif2, thereby repressing the functional role of Tgif2 in cellular senescence.
    Title: The juvenility-associated long noncoding RNA Gm14230 maintains cellular juvenescence.
  4. Tgif2 plays an important role in the regulation of osteoblastic differentiation in vitro
    Title: TGFβ-induced factor homeobox 2 blocks osteoblastic differentiation through targeting pSmad3/HDAC4/H4ac/Runx2 axis.
  5. Tgifs play an important role in regulating basic energy metabolism in normal cells, and that this function of Tgifs is amplified in some cancers.
    Title: TGIF transcription factors repress acetyl CoA metabolic gene expression and promote intestinal tumor growth.
  6. Studies indicate the reprogramming activity of TG-interacting factor 2 (TGIF2) and suggest a stepwise reprogramming paradigm.
    Title: Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.
  7. Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect.
    Title: Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l.
  8. loss of Tgif1 causes axial patterning defects that are enhanced by mutations in Tgif2
    Title: Tgif1 and Tgif2 Regulate Axial Patterning in Mouse.
  9. Data show that loss-of-function mutations in both Tgif1 and Tgif2 result in a failure of gastrulation.
    Title: Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation.
  10. TGIF2 is the molecular link between dorsoventral patterning of the endoderm and pancreatic specification.
    Title: The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of amacrine cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within nodal signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of amacrine cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of gastrulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within retina development in camera-type eye IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
homeobox protein TGIF2
Names
5'-TG-3'-interacting factor 2
TALE family homeobox
TGF-beta-induced transcription factor 2
TGFB-induced factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291124.1 → NP_001278053.1  homeobox protein TGIF2 isoform b

    See identical proteins and their annotated locations for NP_001278053.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK029490, AL935150, BQ030806, CF731285
    Consensus CDS
    CCDS71173.1
    UniProtKB/TrEMBL
    Q3TZS1
    Related
    ENSMUSP00000073074.4, ENSMUST00000073352.10
    Conserved Domains (1) summary
    pfam05920
    Location:36 → 75
    Homeobox_KN; Homeobox KN domain

  2. NM_173396.3 → NP_775572.1  homeobox protein TGIF2 isoform a

    See identical proteins and their annotated locations for NP_775572.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK029490, AL935150, BQ030806
    Consensus CDS
    CCDS16969.1
    UniProtKB/Swiss-Prot
    Q8C0Y1
    UniProtKB/TrEMBL
    A2AVY9
    Related
    ENSMUSP00000096745.5, ENSMUST00000081335.13
    Conserved Domains (1) summary
    pfam05920
    Location:36 → 75
    Homeobox_KN; Homeobox KN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    156681737..156697490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499353.3 → XP_006499416.1  homeobox protein TGIF2 isoform X1

    See identical proteins and their annotated locations for XP_006499416.1

    UniProtKB/Swiss-Prot
    Q8C0Y1
    UniProtKB/TrEMBL
    A2AVY9
    Conserved Domains (1) summary
    pfam05920
    Location:36 → 75
    Homeobox_KN; Homeobox KN domain

  2. XM_006499354.5 → XP_006499417.1  homeobox protein TGIF2 isoform X1

    See identical proteins and their annotated locations for XP_006499417.1

    UniProtKB/Swiss-Prot
    Q8C0Y1
    UniProtKB/TrEMBL
    A2AVY9
    Conserved Domains (1) summary
    pfam05920
    Location:36 → 75
    Homeobox_KN; Homeobox KN domain

  3. XM_036161592.1 → XP_036017485.1  homeobox protein TGIF2 isoform X2

    UniProtKB/TrEMBL
    Q3TZS1
    Conserved Domains (1) summary
    pfam05920
    Location:36 → 75
    Homeobox_KN; Homeobox KN domain

  4. XM_006499351.5 → XP_006499414.1  homeobox protein TGIF2 isoform X1

    See identical proteins and their annotated locations for XP_006499414.1

    UniProtKB/Swiss-Prot
    Q8C0Y1
    UniProtKB/TrEMBL
    A2AVY9
    Conserved Domains (1) summary
    pfam05920
    Location:36 → 75
    Homeobox_KN; Homeobox KN domain

  5. XM_030250654.2 → XP_030106514.1  homeobox protein TGIF2 isoform X2

    UniProtKB/TrEMBL
    Q3TZS1
    Conserved Domains (1) summary
    pfam05920
    Location:36 → 75
    Homeobox_KN; Homeobox KN domain

  6. XM_036161591.1 → XP_036017484.1  homeobox protein TGIF2 isoform X2

    UniProtKB/TrEMBL
    Q3TZS1
    Conserved Domains (1) summary
    pfam05920
    Location:36 → 75
    Homeobox_KN; Homeobox KN domain

  7. XM_006499352.5 → XP_006499415.1  homeobox protein TGIF2 isoform X1

    See identical proteins and their annotated locations for XP_006499415.1

    UniProtKB/Swiss-Prot
    Q8C0Y1
    UniProtKB/TrEMBL
    A2AVY9
    Conserved Domains (1) summary
    pfam05920
    Location:36 → 75
    Homeobox_KN; Homeobox KN domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0Y1.1 GenPept UniProtKB/Swiss-Prot:Q8C0Y1

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