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Dlgap4 DLG associated protein 4 [ Mus musculus (house mouse) ]

Gene ID: 228836, updated on 21-Apr-2024

Summary

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Official Symbol
Dlgap4provided by MGI
Official Full Name
DLG associated protein 4provided by MGI
Primary source
MGI:MGI:2138865
See related
Ensembl:ENSMUSG00000061689 AllianceGenome:MGI:2138865
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DAP4; DAP-4; WBP16; Sapap4; SAPAP-4
Summary
This gene encodes a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. The encoded protein may play a role in synapse organization and neuronal signalling. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 22.1), CNS E18 (RPKM 21.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H1; 2 77.54 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156455431..156606283)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156613633..156764363)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156373177-156373360 Neighboring gene AAR2 splicing factor homolog Neighboring gene predicted gene 14169 Neighboring gene predicted gene 14172 Neighboring gene predicted gene, 52566 Neighboring gene RIKEN cDNA 4930405A21 gene Neighboring gene STARR-seq mESC enhancer starr_06181 Neighboring gene STARR-seq mESC enhancer starr_06182 Neighboring gene myosin, light polypeptide 9, regulatory Neighboring gene ribosomal protein L9 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sapap4 deficiency leads to postsynaptic defects and abnormal behaviors relevant to hyperkinetic neuropsychiatric disorder in mice. Wang T, et al. Cereb Cortex, 2023 Feb 7. PMID 35368073
  2. Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice. Schob C, et al. Transl Psychiatry, 2019 Jan 16. PMID 30664629, Free PMC Article
  3. SAPAP4 Deletion Causes Synaptic Dysfunction in the nucleus accumbens. Wu B, et al. Biochem Biophys Res Commun, 2018 Nov 10. PMID 30322620
  4. Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder. Wan Y, et al. Biol Psychiatry, 2014 Apr 15. PMID 23414593, Free PMC Article
  5. Novel role of the synaptic scaffold protein Dlgap4 in ventricular surface integrity and neuronal migration during cortical development. Romero DM, et al. Nat Commun, 2022 May 18. PMID 35585091, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sapap4 deficiency leads to postsynaptic defects and abnormal behaviors relevant to hyperkinetic neuropsychiatric disorder in mice.
    Title: Sapap4 deficiency leads to postsynaptic defects and abnormal behaviors relevant to hyperkinetic neuropsychiatric disorder in mice.
  2. Novel role of the synaptic scaffold protein Dlgap4 in ventricular surface integrity and neuronal migration during cortical development.
    Title: Novel role of the synaptic scaffold protein Dlgap4 in ventricular surface integrity and neuronal migration during cortical development.
  3. The behavioural alterations of SAPAP4-deficient mice are associated with dramatic changes in synapse morphology, function and plasticity, indicating that SAPAP4 is critical for the development of functional neuronal networks
    Title: Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice.
  4. The findings demonstrate that SAPAP4 plays a critical role in in the synaptic function of the nucleus accumbens.
    Title: SAPAP4 Deletion Causes Synaptic Dysfunction in the nucleus accumbens.
  5. Detection of significantly increased postsynaptic density-95 induced by behavioral training at the protein level per se is intriguing and supports the proposed importance of this molecule for neuronal information storage.
    Title: Behavioral testing upregulates pCaMKII, BDNF, PSD-95 and egr-1 in hippocampus of FVB/N mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0964, MGC37636, MGC117830

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in modification of postsynaptic structure IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modification of postsynaptic structure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synapse maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signaling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cholinergic synapse IC
Inferred by Curator
more info
 PubMed 
is_active_in cholinergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cholinergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuromuscular junction IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic specialization IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic specialization IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic specialization IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
disks large-associated protein 4
Names
PSD-95/SAP90-binding protein 4
SAP90/PSD-95-associated protein 4
WW domain-binding protein 16
discs, large homolog-associated protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042487.1 → NP_001035952.1  disks large-associated protein 4 isoform b

    See identical proteins and their annotated locations for NP_001035952.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks several 5' coding exons, and initiates translation at an alternate start codon, compared to variant 1. It represents use of an alternate promoter. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    BC058948, BC085475, CF725232
    Consensus CDS
    CCDS38299.1
    UniProtKB/TrEMBL
    Q3UCF7
    Related
    ENSMUSP00000096749.6, ENSMUST00000099145.6
    Conserved Domains (1) summary
    pfam03359
    Location:121 → 453
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  2. NM_001042488.2 → NP_001035953.1  disks large-associated protein 4 isoform c

    See identical proteins and their annotated locations for NP_001035953.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks several 5' coding exons, and initiates translation at a downstream in-frame start codon, compared to variant 1. It represents use of an alternate promoter. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK150554, BC058948, BX004793, BY298512
    Consensus CDS
    CCDS38300.1
    UniProtKB/TrEMBL
    E9PUF2, F6YMR0
    Related
    ENSMUSP00000105194.3, ENSMUST00000109566.9
    Conserved Domains (1) summary
    pfam03359
    Location:1 → 285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  3. NM_001277186.1 → NP_001264115.1  disks large-associated protein 4 isoform d

    See identical proteins and their annotated locations for NP_001264115.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon and contains an alternate in-frame exon, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    BC058948, BX004793, BX571766, BY122638, CJ111046, CJ117510, CX210973
    Consensus CDS
    CCDS71171.1
    UniProtKB/Swiss-Prot
    B1AZP2
    Related
    ENSMUSP00000105195.4, ENSMUST00000109567.10
    Conserved Domains (1) summary
    pfam03359
    Location:647 → 989
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  4. NM_001277187.1 → NP_001264116.1  disks large-associated protein 4 isoform e

    See identical proteins and their annotated locations for NP_001264116.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (e) is shorter than isoform a.
    Source sequence(s)
    BC058948, BX004793, BY122638, CJ111046, CJ117510, CX210973
    Consensus CDS
    CCDS71172.1
    UniProtKB/TrEMBL
    B7ZNS2
    Related
    ENSMUSP00000105196.4, ENSMUST00000109568.10
    Conserved Domains (1) summary
    pfam03359
    Location:643 → 975
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  5. NM_146128.6 → NP_666240.4  disks large-associated protein 4 isoform a

    See identical proteins and their annotated locations for NP_666240.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BC058948, BX004793, BY122638, CJ111046, CJ117510, CX210973
    Consensus CDS
    CCDS16968.1
    UniProtKB/Swiss-Prot
    B1AZP2, B1AZP3, B7ZNS1, Q3KQQ8, Q6PD44, Q6XBF1, Q80TN3, Q8R3U9
    Related
    ENSMUSP00000126980.3, ENSMUST00000169464.9
    Conserved Domains (1) summary
    pfam03359
    Location:660 → 992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    156455431..156606283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161542.1 → XP_036017435.1  disks large-associated protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B1AZP2, B1AZP3, B7ZNS1, Q3KQQ8, Q6PD44, Q6XBF1, Q80TN3, Q8R3U9
    Conserved Domains (1) summary
    pfam03359
    Location:660 → 992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  2. XM_017317840.3 → XP_017173329.1  disks large-associated protein 4 isoform X4

    Conserved Domains (1) summary
    pfam03359
    Location:650 → 917
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  3. XM_006499341.4 → XP_006499404.1  disks large-associated protein 4 isoform X3

    Conserved Domains (1) summary
    pfam03359
    Location:660 → 920
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  4. XM_036161546.1 → XP_036017439.1  disks large-associated protein 4 isoform X2

    Conserved Domains (1) summary
    pfam03359
    Location:647 → 989
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  5. XM_006499340.5 → XP_006499403.1  disks large-associated protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006499403.1

    UniProtKB/Swiss-Prot
    B1AZP2, B1AZP3, B7ZNS1, Q3KQQ8, Q6PD44, Q6XBF1, Q80TN3, Q8R3U9
    Conserved Domains (1) summary
    pfam03359
    Location:660 → 992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  6. XM_030250649.1 → XP_030106509.1  disks large-associated protein 4 isoform X9

    UniProtKB/TrEMBL
    E9PUF2, F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:1 → 285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  7. XM_036161568.1 → XP_036017461.1  disks large-associated protein 4 isoform X9

    UniProtKB/TrEMBL
    E9PUF2, F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:1 → 285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  8. XM_006499350.5 → XP_006499413.1  disks large-associated protein 4 isoform X9

    See identical proteins and their annotated locations for XP_006499413.1

    UniProtKB/TrEMBL
    E9PUF2, F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:1 → 285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  9. XM_030250650.2 → XP_030106510.1  disks large-associated protein 4 isoform X9

    UniProtKB/TrEMBL
    E9PUF2, F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:1 → 285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  10. XM_006499343.5 → XP_006499406.1  disks large-associated protein 4 isoform X8

    See identical proteins and their annotated locations for XP_006499406.1

    UniProtKB/TrEMBL
    F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:17 → 298
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  11. XM_006499348.5 → XP_006499411.1  disks large-associated protein 4 isoform X9

    See identical proteins and their annotated locations for XP_006499411.1

    UniProtKB/TrEMBL
    E9PUF2, F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:1 → 285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  12. XM_017317843.2 → XP_017173332.1  disks large-associated protein 4 isoform X7

    UniProtKB/TrEMBL
    Q3UCF7
    Conserved Domains (1) summary
    pfam03359
    Location:111 → 450
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  13. XM_017317848.2 → XP_017173337.1  disks large-associated protein 4 isoform X9

    UniProtKB/TrEMBL
    E9PUF2, F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:1 → 285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  14. XM_036161580.1 → XP_036017473.1  disks large-associated protein 4 isoform X9

    UniProtKB/TrEMBL
    E9PUF2, F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:1 → 285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  15. XM_036161581.1 → XP_036017474.1  disks large-associated protein 4 isoform X9

    UniProtKB/TrEMBL
    E9PUF2, F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:1 → 285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  16. XM_036161571.1 → XP_036017464.1  disks large-associated protein 4 isoform X9

    UniProtKB/TrEMBL
    E9PUF2, F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:1 → 285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  17. XM_006499346.5 → XP_006499409.1  disks large-associated protein 4 isoform X8

    See identical proteins and their annotated locations for XP_006499409.1

    UniProtKB/TrEMBL
    F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:17 → 298
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  18. XM_030250653.2 → XP_030106513.1  disks large-associated protein 4 isoform X9

    UniProtKB/TrEMBL
    E9PUF2, F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:1 → 285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  19. XM_006499349.3 → XP_006499412.1  disks large-associated protein 4 isoform X9

    See identical proteins and their annotated locations for XP_006499412.1

    UniProtKB/TrEMBL
    E9PUF2, F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:1 → 285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  20. XM_030250652.2 → XP_030106512.1  disks large-associated protein 4 isoform X9

    UniProtKB/TrEMBL
    E9PUF2, F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:1 → 285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  21. XM_006499344.4 → XP_006499407.1  disks large-associated protein 4 isoform X8

    See identical proteins and their annotated locations for XP_006499407.1

    UniProtKB/TrEMBL
    F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:17 → 298
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  22. XM_030250651.2 → XP_030106511.1  disks large-associated protein 4 isoform X9

    UniProtKB/TrEMBL
    E9PUF2, F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:1 → 285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  23. XM_036161559.1 → XP_036017452.1  disks large-associated protein 4 isoform X8

    UniProtKB/TrEMBL
    F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:17 → 298
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  24. XM_036161553.1 → XP_036017446.1  disks large-associated protein 4 isoform X6

    UniProtKB/TrEMBL
    Q3UCF7
    Conserved Domains (1) summary
    pfam03359
    Location:149 → 491
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  25. XM_006499342.5 → XP_006499405.1  disks large-associated protein 4 isoform X5

    UniProtKB/TrEMBL
    Q3UCF7
    Conserved Domains (1) summary
    pfam03359
    Location:162 → 494
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  26. XM_006499345.5 → XP_006499408.1  disks large-associated protein 4 isoform X8

    See identical proteins and their annotated locations for XP_006499408.1

    UniProtKB/TrEMBL
    F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:17 → 298
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  27. XM_017317850.3 → XP_017173339.1  disks large-associated protein 4 isoform X9

    UniProtKB/TrEMBL
    E9PUF2, F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:1 → 285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  28. XM_036161569.1 → XP_036017462.1  disks large-associated protein 4 isoform X9

    UniProtKB/TrEMBL
    E9PUF2, F6YMR0
    Conserved Domains (1) summary
    pfam03359
    Location:1 → 285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

RNA

  1. XR_003952548.2 RNA Sequence

  2. XR_003952547.2 RNA Sequence

  3. XR_003952549.2 RNA Sequence

  4. XR_001782346.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1AZP2.1 GenPept UniProtKB/Swiss-Prot:B1AZP2

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