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Xkr7 X-linked Kx blood group related 7 [ Mus musculus (house mouse) ]

Gene ID: 228787, updated on 5-Mar-2024

Summary

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Official Symbol
Xkr7provided by MGI
Official Full Name
X-linked Kx blood group related 7provided by MGI
Primary source
MGI:MGI:3526711
See related
Ensembl:ENSMUSG00000042631 AllianceGenome:MGI:3526711
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in apoptotic process involved in development; engulfment of apoptotic cell; and phosphatidylserine exposure on apoptotic cell surface. Is active in plasma membrane. Orthologous to human XKR7 (XK related 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 4.3), CNS E18 (RPKM 3.2) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H1; 2 75.41 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152873772..152902214)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (153031852..153060294)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene tubulin tyrosine ligase-like family, member 9 Neighboring gene predicted gene 14199 Neighboring gene STARR-positive B cell enhancer mm9_chr2:152840956-152841257 Neighboring gene p53 and DNA damage regulated 1 Neighboring gene predicted gene, 32286 Neighboring gene cerebral cavernous malformation 2-like Neighboring gene hemopoietic cell kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Exposure of phosphatidylserine by Xk-related protein family members during apoptosis. Suzuki J, et al. J Biol Chem, 2014 Oct 31. PMID 25231987, Free PMC Article
  2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in apoptotic process involved in development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in engulfment of apoptotic cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylserine exposure on apoptotic cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
XK-related protein 7
Names
X Kell blood group precursor related family member 7 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011732.1 → NP_001011732.1  XK-related protein 7

    See identical proteins and their annotated locations for NP_001011732.1

    Status: PROVISIONAL

    Source sequence(s)
    AY534253
    Consensus CDS
    CCDS16905.1
    UniProtKB/Swiss-Prot
    A2ATH3, Q5GH64
    Related
    ENSMUSP00000049346.7, ENSMUST00000037235.7
    Conserved Domains (1) summary
    pfam09815
    Location:59 → 442
    XK-related; XK-related protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152873772..152902214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250595.1 → XP_030106455.1  XK-related protein 7 isoform X3

    Conserved Domains (2) summary
    PHA02682
    Location:219 → 315
    PHA02682; ORF080 virion core protein; Provisional
    pfam09815
    Location:1 → 222
    XK-related; XK-related protein

  2. XM_006499323.4 → XP_006499386.1  XK-related protein 7 isoform X2

    Conserved Domains (2) summary
    PHA02682
    Location:246 → 372
    PHA02682; ORF080 virion core protein; Provisional
    pfam09815
    Location:2 → 249
    XK-related; XK-related protein

  3. XM_006499321.4 → XP_006499384.1  XK-related protein 7 isoform X1

    Conserved Domains (2) summary
    PHA02682
    Location:253 → 379
    PHA02682; ORF080 virion core protein; Provisional
    pfam09815
    Location:10 → 256
    XK-related; XK-related protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5GH64.1 GenPept UniProtKB/Swiss-Prot:Q5GH64

Gene LinkOut

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