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Zfp770 zinc finger protein 770 [ Mus musculus (house mouse) ]

Gene ID: 228491, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp770provided by MGI
Official Full Name
zinc finger protein 770provided by MGI
Primary source
MGI:MGI:2445100
See related
Ensembl:ENSMUSG00000040321 AllianceGenome:MGI:2445100
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf770; 6430601A21Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF770 (zinc finger protein 770). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 3.5), cerebellum adult (RPKM 2.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E4; 2 57.61 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (114023937..114031945, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (114193456..114201432, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54143 Neighboring gene VISTA enhancer mm182 Neighboring gene STARR-positive B cell enhancer mm9_chr2:113971248-113971549 Neighboring gene aquarius Neighboring gene STARR-positive B cell enhancer ABC_E1593 Neighboring gene STARR-seq mESC enhancer starr_05403 Neighboring gene microRNA 7002 Neighboring gene STARR-seq mESC enhancer starr_05404 Neighboring gene STARR-seq mESC enhancer starr_05405 Neighboring gene STARR-seq mESC enhancer starr_05406 Neighboring gene STARR-seq mESC enhancer starr_05407 Neighboring gene STARR-seq mESC enhancer starr_05408 Neighboring gene STARR-seq mESC enhancer starr_05409 Neighboring gene predicted gene, 31146 Neighboring gene STARR-seq mESC enhancer starr_05410 Neighboring gene predicted gene, 54144

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 770

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175466.5 → NP_780675.1  zinc finger protein 770

    See identical proteins and their annotated locations for NP_780675.1

    Status: VALIDATED

    Source sequence(s)
    AL844569
    Consensus CDS
    CCDS16566.1
    UniProtKB/Swiss-Prot
    Q3TPP6, Q8BIQ8, Q8BK15, Q8BLQ1
    UniProtKB/TrEMBL
    B2RPX9
    Related
    ENSMUSP00000052194.4, ENSMUST00000050668.4
    Conserved Domains (2) summary
    sd00017
    Location:166 → 186
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:500 → 524
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    114023937..114031945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161339.1 → XP_036017232.1  zinc finger protein 770 isoform X1

    UniProtKB/Swiss-Prot
    Q3TPP6, Q8BIQ8, Q8BK15, Q8BLQ1
    UniProtKB/TrEMBL
    B2RPX9
    Conserved Domains (2) summary
    sd00017
    Location:166 → 186
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:500 → 524
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BIQ8.1 GenPept UniProtKB/Swiss-Prot:Q8BIQ8

Gene LinkOut

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