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ZNF507 zinc finger protein 507 [ Homo sapiens (human) ]

Gene ID: 22847, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF507provided by HGNC
Official Full Name
zinc finger protein 507provided by HGNC
Primary source
HGNC:HGNC:23783
See related
Ensembl:ENSG00000168813 MIM:620567; AllianceGenome:HGNC:23783
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Zfp507
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 9.1), thyroid (RPKM 7.3) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19q13.11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (32345610..32387667)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (34864228..34906309)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (32836516..32878573)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 472 Neighboring gene uncharacterized LOC124904688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10479 Neighboring gene uncharacterized LOC124904689 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:32845640-32845808 Neighboring gene Sharpr-MPRA regulatory region 4314 Neighboring gene DPY19L3 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10481 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:32911836-32912044 Neighboring gene dpy-19 like C-mannosyltransferase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14429

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF507 affects TGF-β signaling via TGFBR1 and MAP3K8 activation in the progression of prostate cancer to an aggressive state. Kwon W, et al. J Exp Clin Cancer Res, 2021 Sep 18. PMID 34537073, Free PMC Article
  2. ZNF146/OZF and ZNF507 target LINE-1 sequences. Creamer KM, et al. G3 (Bethesda), 2022 Mar 4. PMID 35100360, Free PMC Article
  3. The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis. Funato Y, et al. Dev Cell, 2020 Nov 23. PMID 32918875
  4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Kikuno R, et al. DNA Res, 1999 Jun 30. PMID 10470851
  5. USP7 Regulates Cytokinesis through FBXO38 and KIF20B. Georges A, et al. Sci Rep, 2019 Feb 25. PMID 30804394, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF146/OZF and ZNF507 target LINE-1 sequences.
    Title: ZNF146/OZF and ZNF507 target LINE-1 sequences.
  2. ZNF507 affects TGF-beta signaling via TGFBR1 and MAP3K8 activation in the progression of prostate cancer to an aggressive state.
    Title: ZNF507 affects TGF-β signaling via TGFBR1 and MAP3K8 activation in the progression of prostate cancer to an aggressive state.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 507

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136156.2 → NP_001129628.1  zinc finger protein 507

    See identical proteins and their annotated locations for NP_001129628.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC007773, AL713775, BU681879, BX640881, CK820221, DB165165
    Consensus CDS
    CCDS32985.1
    UniProtKB/Swiss-Prot
    A8K911, Q2TBF1, Q6MZU0, Q8TCN5, Q9UPR8
    UniProtKB/TrEMBL
    B9EGE7
    Related
    ENSP00000348162.4, ENST00000355898.6
    Conserved Domains (2) summary
    sd00017
    Location:643 → 663
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:773 → 797
    zf-H2C2_2; Zinc-finger double domain

  2. NM_014910.5 → NP_055725.2  zinc finger protein 507

    See identical proteins and their annotated locations for NP_055725.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC007773, BU681879, BX640881, CK820221, DB165165
    Consensus CDS
    CCDS32985.1
    UniProtKB/Swiss-Prot
    A8K911, Q2TBF1, Q6MZU0, Q8TCN5, Q9UPR8
    UniProtKB/TrEMBL
    B9EGE7
    Related
    ENSP00000312277.2, ENST00000311921.8
    Conserved Domains (2) summary
    sd00017
    Location:643 → 663
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:773 → 797
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    32345610..32387667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    34864228..34906309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TCN5.2 GenPept UniProtKB/Swiss-Prot:Q8TCN5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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