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Kif18a kinesin family member 18A [ Mus musculus (house mouse) ]

Gene ID: 228421, updated on 11-Apr-2024

Summary

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Official Symbol
Kif18aprovided by MGI
Official Full Name
kinesin family member 18Aprovided by MGI
Primary source
MGI:MGI:2446977
See related
Ensembl:ENSMUSG00000027115 AllianceGenome:MGI:2446977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gcd2; B130001M12Rik
Summary
Predicted to enable several functions, including ATP hydrolysis activity; cytoskeletal protein binding activity; and plus-end-directed microtubule motor activity. Acts upstream of or within nuclear division; regulation of microtubule cytoskeleton organization; and seminiferous tubule development. Located in kinetochore and mitotic spindle midzone. Is expressed in central nervous system; gonad; and retina. Orthologous to human KIF18A (kinesin family member 18A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 8.8), CNS E11.5 (RPKM 7.2) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Kif18a in Genome Data Viewer
Location:
2 E3; 2 56.55 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (109111165..109172094)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (109280738..109341749)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05346 Neighboring gene predicted gene 13923 Neighboring gene methyltransferase like 15 Neighboring gene STARR-seq mESC enhancer starr_05347 Neighboring gene STARR-seq mESC enhancer starr_05348 Neighboring gene STARR-seq mESC enhancer starr_05349 Neighboring gene STARR-positive B cell enhancer ABC_E5956 Neighboring gene STARR-seq mESC enhancer starr_05353 Neighboring gene STARR-seq mESC enhancer starr_05354 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05355 Neighboring gene brain-derived neurotrophic factor antisense RNA Neighboring gene brain derived neurotrophic factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mitotic chromosome alignment ensures mitotic fidelity by promoting interchromosomal compaction during anaphase. Fonseca CL, et al. J Cell Biol, 2019 Apr 1. PMID 30733233, Free PMC Article
  2. Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis. Sepaniac LA, et al. J Cell Biol, 2021 Nov 1. PMID 34515734, Free PMC Article
  3. Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells. Kim S, et al. Genes Genomics, 2020 Jan. PMID 31677127
  4. Targeted deletion of Kif18a protects from colitis-associated colorectal (CAC) tumors in mice through impairing Akt phosphorylation. Zhu H, et al. Biochem Biophys Res Commun, 2013 Aug 16. PMID 23872115
  5. Germinal Cell Aplasia in Kif18a Mutant Male Mice Due to Impaired Chromosome Congression and Dysregulated BubR1 and CENP-E. Liu XS, et al. Genes Cancer, 2010 Jan. PMID 20981276, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis.
    Title: Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis.
  2. phylogenetic analysis revealed that the KIF18A gene family is remarkably conserved across vertebrates.
    Title: Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells.
  3. Kif18a is specifically required for mitotic progression during germ line development.
    Title: Kif18a is specifically required for mitotic progression during germ line development.
  4. In conclusion, Kif18a is critical for colorectal carcinogenesis in the setting of inflammation by mechanisms of increased PI3K-AKT signaling.
    Title: Targeted deletion of Kif18a protects from colitis-associated colorectal (CAC) tumors in mice through impairing Akt phosphorylation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC27627

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule plus-end binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables plus-end-directed microtubule motor activity ISO
Inferred from Sequence Orthology
more info
  
enables tubulin-dependent ATPase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within seminiferous tubule development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in caveola ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle astral microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF18A
Names
N-8 kinesin
kinesin superfamily protein 18A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418960.1 → NP_001405889.1  kinesin-like protein KIF18A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL691430

  2. NM_001418961.1 → NP_001405890.1  kinesin-like protein KIF18A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL691430
    UniProtKB/TrEMBL
    Q8BZ45
    Related
    ENSMUST00000144924.8

  3. NM_001418962.1 → NP_001405891.1  kinesin-like protein KIF18A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL691430
    UniProtKB/TrEMBL
    Q8BY99
    Related
    ENSMUST00000151395.8

  4. NM_001418963.1 → NP_001405892.1  kinesin-like protein KIF18A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL691430

  5. NM_139303.2 → NP_647464.1  kinesin-like protein KIF18A isoform 1

    See identical proteins and their annotated locations for NP_647464.1

    Status: VALIDATED

    Source sequence(s)
    AL691430
    Consensus CDS
    CCDS16507.1
    UniProtKB/Swiss-Prot
    Q3TP77, Q8BLL1, Q91WD7
    Related
    ENSMUSP00000028527.8, ENSMUST00000028527.8
    Conserved Domains (2) summary
    cd01370
    Location:11 → 355
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
    pfam00225
    Location:17 → 355
    Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    109111165..109172094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WD7.1 GenPept UniProtKB/Swiss-Prot:Q91WD7

Gene LinkOut

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