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Prrg4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) [ Mus musculus (house mouse) ]

Gene ID: 228413, updated on 5-Mar-2024

Summary

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Official Symbol
Prrg4provided by MGI
Official Full Name
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)provided by MGI
Primary source
MGI:MGI:2442211
See related
Ensembl:ENSMUSG00000027171 AllianceGenome:MGI:2442211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TMG4; 9930111I18Rik
Summary
Predicted to enable WW domain binding activity. Predicted to be located in extracellular region and membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human PRRG4 (proline rich and Gla domain 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 2.9), bladder adult (RPKM 1.7) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E2; 2 54.98 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (104657374..104680216, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (104830741..104849872, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39898 Neighboring gene TAR DNA binding protein pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7844 Neighboring gene STARR-seq mESC enhancer starr_05298 Neighboring gene STARR-positive B cell enhancer mm9_chr2:104728128-104728428 Neighboring gene coiled-coil domain containing 73 Neighboring gene STARR-positive B cell enhancer mm9_chr2:104828551-104828851 Neighboring gene eukaryotic translation initiation factor 3, subunit M Neighboring gene predicted gene, 38521

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117538

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane gamma-carboxyglutamic acid protein 4
Names
proline-rich Gla protein 4
proline-rich gamma-carboxyglutamic acid protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178695.5 → NP_848810.3  transmembrane gamma-carboxyglutamic acid protein 4 precursor

    See identical proteins and their annotated locations for NP_848810.3

    Status: VALIDATED

    Source sequence(s)
    AK035530, AK038703
    Consensus CDS
    CCDS16493.1
    UniProtKB/Swiss-Prot
    Q8BGN6, Q8BM25
    UniProtKB/TrEMBL
    Q3TLN5, Q4KL73
    Related
    ENSMUSP00000028593.5, ENSMUST00000028593.11
    Conserved Domains (2) summary
    pfam00594
    Location:57 → 97
    Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    cl15239
    Location:78 → 178
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    104657374..104680216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250334.2 → XP_030106194.1  transmembrane gamma-carboxyglutamic acid protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q8BGN6, Q8BM25
    UniProtKB/TrEMBL
    Q3TLN5, Q4KL73
    Conserved Domains (2) summary
    pfam00594
    Location:57 → 97
    Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    cl15239
    Location:78 → 178
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGN6.1 GenPept UniProtKB/Swiss-Prot:Q8BGN6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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