Arhgap1 Rho GTPase activating protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap1provided by MGI
Official Full Name: Rho GTPase activating protein 1provided by MGI
Primary source: MGI:MGI:2445003
See related: Ensembl:ENSMUSG00000027247 AllianceGenome:MGI:2445003
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cdc42GAP; p50rhoGAP; B230365D05Rik
Summary: Enables GTPase activator activity. Acts upstream of or within regulation of GTPase activity. Located in plasma membrane and ruffle. Orthologous to human ARHGAP1 (Rho GTPase activating protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 49.0), lung adult (RPKM 47.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E1; 2 50.63 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (91480463..91502670)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (91650118..91672325)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cdc42GAP deficiency contributes to the Alzheimer's disease phenotype.
Title: Cdc42GAP deficiency contributes to the Alzheimer's disease phenotype.
Structural basis for p50RhoGAP BCH domain-mediated regulation of Rho inactivation.
Title: Structural basis for p50RhoGAP BCH domain-mediated regulation of Rho inactivation.
ARHGAP 18 is a protective gene that maintains EC alignments in the direction of flow. Deletion of ARHGAP 18 led to loss of EC ability to align and promoted
Title: ARHGAP18: A Flow-Responsive Gene That Regulates Endothelial Cell Alignment and Protects Against Atherosclerosis.
These results demonstrate a different requirement of Cdc42 activity in primary mouse embryo fibroblasts suggesting that Cdc42 plays cell-type-specific signaling roles.
Title: Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237116

RH125946 (e-PCR)
- UniSTS:162658

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endosomal transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endocytic recycling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in transferrin transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with sorting endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 1

Names: rho-type GTPase-activating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145902.1 → NP_001139374.1 rho GTPase-activating protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK046291, AL691489, BC089306

Consensus CDS

CCDS50641.1

UniProtKB/TrEMBL

A2AH25, Q8BQW4

Related

ENSMUSP00000106963.3, ENSMUST00000111331.9

Conserved Domains (2) summary

cd04404
Location:279 → 471

RhoGAP-p50rhoGAP; RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol ...

pfam13716
Location:122 → 246

CRAL_TRIO_2; Divergent CRAL/TRIO domain
NM_001359970.1 → NP_001346899.1 rho GTPase-activating protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' structure, resulting in a novel 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 6 encode the same isoform.

Source sequence(s)

AL691489, AL714023

Consensus CDS

CCDS16437.1

UniProtKB/Swiss-Prot

Q5FWK3, Q8C3X5, Q923D8

UniProtKB/TrEMBL

A0A2X0SSA9

Related

ENSMUSP00000088105.5, ENSMUST00000090614.11

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain
NM_146124.4 → NP_666236.3 rho GTPase-activating protein 1 isoform 2

See identical proteins and their annotated locations for NP_666236.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' structure, resulting in a novel 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 6 encode the same isoform.

Source sequence(s)

AK084622, BC089306

Consensus CDS

CCDS16437.1

UniProtKB/Swiss-Prot

Q5FWK3, Q8C3X5, Q923D8

UniProtKB/TrEMBL

A0A2X0SSA9

Related

ENSMUSP00000106962.3, ENSMUST00000111330.3

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain

RNA

NR_027371.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate exon compared to variant 1. This exon disrupts the reading frame of the protein and makes this transcript a candidate for nonsense-mediated mRNA decay. This variant is not thought to encode a protein.

Source sequence(s)

AK046291, AK085554, BC089306, BY294066
NR_027372.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate exon compared to variant 1. This exon disrupts the reading frame of the protein and makes this transcript a candidate for nonsense-mediated mRNA decay. This variant is not thought to encode a protein.

Source sequence(s)

AK046291, AK079048, BC089306, BY294066
NR_027373.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) contains an alternate exon and alternate splice junction compared to variant 1. These differences disrupt the reading frame of the protein and make this transcript a candidate for nonsense-mediated mRNA decay. This variant is not thought to encode a protein.

Source sequence(s)

AK046291, BC089306, BQ571397, BY294066

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

91480463..91502670

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499251.2 → XP_006499314.1 rho GTPase-activating protein 1 isoform X2

UniProtKB/TrEMBL

Q8C5A0

Conserved Domains (2) summary

cd04404
Location:202 → 394

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:45 → 179

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_006499249.3 → XP_006499312.1 rho GTPase-activating protein 1 isoform X1

See identical proteins and their annotated locations for XP_006499312.1

UniProtKB/Swiss-Prot

Q5FWK3, Q8C3X5, Q923D8

UniProtKB/TrEMBL

A0A2X0SSA9

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_006499248.4 → XP_006499311.1 rho GTPase-activating protein 1 isoform X1

See identical proteins and their annotated locations for XP_006499311.1

UniProtKB/Swiss-Prot

Q5FWK3, Q8C3X5, Q923D8

UniProtKB/TrEMBL

A0A2X0SSA9

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_006499244.2 → XP_006499307.1 rho GTPase-activating protein 1 isoform X1

See identical proteins and their annotated locations for XP_006499307.1

UniProtKB/Swiss-Prot

Q5FWK3, Q8C3X5, Q923D8

UniProtKB/TrEMBL

A0A2X0SSA9

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_006499245.5 → XP_006499308.1 rho GTPase-activating protein 1 isoform X1

See identical proteins and their annotated locations for XP_006499308.1

UniProtKB/Swiss-Prot

Q5FWK3, Q8C3X5, Q923D8

UniProtKB/TrEMBL

A0A2X0SSA9

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_006499250.2 → XP_006499313.1 rho GTPase-activating protein 1 isoform X1

See identical proteins and their annotated locations for XP_006499313.1

UniProtKB/Swiss-Prot

Q5FWK3, Q8C3X5, Q923D8

UniProtKB/TrEMBL

A0A2X0SSA9

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_011239457.2 → XP_011237759.1 rho GTPase-activating protein 1 isoform X1

See identical proteins and their annotated locations for XP_011237759.1

UniProtKB/Swiss-Prot

Q5FWK3, Q8C3X5, Q923D8

UniProtKB/TrEMBL

A0A2X0SSA9

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_006499247.4 → XP_006499310.1 rho GTPase-activating protein 1 isoform X1

See identical proteins and their annotated locations for XP_006499310.1

UniProtKB/Swiss-Prot

Q5FWK3, Q8C3X5, Q923D8

UniProtKB/TrEMBL

A0A2X0SSA9

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain