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Madd MAP-kinase activating death domain [ Mus musculus (house mouse) ]

Gene ID: 228355, updated on 5-Mar-2024

Summary

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Official Symbol
Maddprovided by MGI
Official Full Name
MAP-kinase activating death domainprovided by MGI
Primary source
MGI:MGI:2444672
See related
Ensembl:ENSMUSG00000040687 AllianceGenome:MGI:2444672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IG20; RabGEF; Rab3GEP; 9630059K23Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in anterograde synaptic vesicle transport; execution phase of apoptosis; and regulation of cell cycle. Acts upstream of or within negative regulation of apoptotic signaling pathway. Predicted to be located in nucleus; plasma membrane; and synaptic vesicle. Predicted to be integral component of membrane. Predicted to be active in cytosol. Is expressed in nervous system; sensory organ; and tongue. Used to study type 2 diabetes mellitus. Orthologous to human MADD (MAP kinase activating death domain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 20.7), cortex adult (RPKM 19.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E1; 2 50.46 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (90967705..91013404, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91137360..91184006, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4476 Neighboring gene Spi-1 proto-oncogene Neighboring gene STARR-positive B cell enhancer ABC_E4477 Neighboring gene STARR-seq mESC enhancer starr_05105 Neighboring gene STARR-seq mESC enhancer starr_05107 Neighboring gene myosin binding protein C, cardiac Neighboring gene STARR-positive B cell enhancer mm9_chr2:91023256-91023557 Neighboring gene STARR-positive B cell enhancer ABC_E4478 Neighboring gene nuclear receptor subfamily 1, group H, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E9070 Neighboring gene predicted gene, 23390 Neighboring gene acid phosphatase 2, lysosomal Neighboring gene damage specific DNA binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IG20/MADD plays a critical role in glucose-induced insulin secretion. Li LC, et al. Diabetes, 2014 May. PMID 24379354, Free PMC Article
  2. A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses. Yamaguchi K, et al. Proc Natl Acad Sci U S A, 2002 Oct 29. PMID 12388783, Free PMC Article
  3. Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle. Lim KM, et al. Int J Cancer, 2004 Mar. PMID 14735464
  4. Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons. Del Villar K, et al. Proc Natl Acad Sci U S A, 2004 Mar 23. PMID 15007167, Free PMC Article
  5. KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD. Niwa S, et al. Nat Cell Biol, 2008 Nov. PMID 18849981

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings indicated that IG20/MADD plays a critical role in glucose-induced insulin release from beta-cells and that its functional disruption can cause type 2 diabetes.
    Title: IG20/MADD plays a critical role in glucose-induced insulin secretion.
  2. role of Rab3 GEP in regulating neurotransmitter release in autapses of mouse hippocampal neurons in culture
    Title: A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses.
  3. DENN has anti-apoptotic and cell survival roles in tumor cells
    Title: Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anterograde synaptic vesicle transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anterograde synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of growth hormone secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of pancreatic amylase secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Rab protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
MAP kinase-activating death domain protein
Names
Rab3 GDP/GTP exchange protein
Rab3 GEP
insulinoma-glucagonoma protein 20
rab3 GDP/GTP exchange factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177719.1 → NP_001171190.1  MAP kinase-activating death domain protein isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) represents the longest transcript and encodes isoform 10.
    Source sequence(s)
    AK036347, AK122257, BC063386
    Consensus CDS
    CCDS50638.1
    UniProtKB/Swiss-Prot
    Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
    UniProtKB/TrEMBL
    A2AGR0
    Related
    ENSMUSP00000097311.3, ENSMUST00000099723.9
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  2. NM_001177720.1 → NP_001171191.1  MAP kinase-activating death domain protein isoform 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) lacks one coding exon, has two additional coding exons, and uses an alternate splice site, compared to variant 10. The resulting isoform (11) is longer and differs at several internal portions and the C-terminus, compared to isoform 10.
    Source sequence(s)
    BC042212, BC063386
    Consensus CDS
    CCDS50635.1
    UniProtKB/TrEMBL
    A2AGQ6, E9QKN1, E9QN47
    Related
    ENSMUSP00000097313.3, ENSMUST00000099725.9
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  3. NM_145527.4 → NP_663502.3  MAP kinase-activating death domain protein isoform 9

    See identical proteins and their annotated locations for NP_663502.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks one exon and uses an alternate splice site in the coding region, compared to variant 10. The resulting isoform (9) differs at two internal portions, compared to isoform 10.
    Source sequence(s)
    AK036347, BC063386
    Consensus CDS
    CCDS38178.1
    UniProtKB/Swiss-Prot
    Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
    UniProtKB/TrEMBL
    A0A0R4J1F4
    Related
    ENSMUSP00000107001.3, ENSMUST00000111370.9
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    90967705..91013404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250251.2 → XP_030106111.1  MAP kinase-activating death domain protein isoform X33

    UniProtKB/TrEMBL
    A2AGQ3
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  2. XM_030250248.2 → XP_030106108.1  MAP kinase-activating death domain protein isoform X31

    UniProtKB/TrEMBL
    A2AGQ3
    Related
    ENSMUSP00000107004.2, ENSMUST00000111373.8
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  3. XM_030250247.2 → XP_030106107.1  MAP kinase-activating death domain protein isoform X30

    UniProtKB/TrEMBL
    A2AGQ3
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  4. XM_036161230.1 → XP_036017123.1  MAP kinase-activating death domain protein isoform X26

    UniProtKB/TrEMBL
    A2AGQ8
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  5. XM_030250245.2 → XP_030106105.1  MAP kinase-activating death domain protein isoform X23

    UniProtKB/TrEMBL
    A2AGQ8
    Related
    ENSMUSP00000107006.2, ENSMUST00000111375.8
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  6. XM_036161217.1 → XP_036017110.1  MAP kinase-activating death domain protein isoform X17

    UniProtKB/TrEMBL
    A2AGQ6
    Related
    ENSMUST00000125321.8
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  7. XM_030250240.2 → XP_030106100.1  MAP kinase-activating death domain protein isoform X16

    UniProtKB/TrEMBL
    A2AGQ7
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  8. XM_030250238.2 → XP_030106098.1  MAP kinase-activating death domain protein isoform X15

    UniProtKB/TrEMBL
    A2AGQ7
    Related
    ENSMUSP00000107003.2, ENSMUST00000111372.8
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  9. XM_036161211.1 → XP_036017104.1  MAP kinase-activating death domain protein isoform X13

    UniProtKB/TrEMBL
    A2AGQ5
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  10. XM_030250227.2 → XP_030106087.1  MAP kinase-activating death domain protein isoform X11

    UniProtKB/TrEMBL
    A2AGQ5
    Related
    ENSMUSP00000107012.3, ENSMUST00000111381.9
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  11. XM_030250208.2 → XP_030106068.1  MAP kinase-activating death domain protein isoform X3

    UniProtKB/TrEMBL
    A2AGQ4
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  12. XM_030250220.2 → XP_030106080.1  MAP kinase-activating death domain protein isoform X8

    UniProtKB/TrEMBL
    A2AGQ5
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  13. XM_030250202.2 → XP_030106062.1  MAP kinase-activating death domain protein isoform X1

    UniProtKB/TrEMBL
    A2AGQ4
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  14. XM_036161224.1 → XP_036017117.1  MAP kinase-activating death domain protein isoform X24

    UniProtKB/Swiss-Prot
    Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  15. XM_036161198.1 → XP_036017091.1  MAP kinase-activating death domain protein isoform X5

    UniProtKB/TrEMBL
    A2AGQ6
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  16. XM_036161257.1 → XP_036017150.1  MAP kinase-activating death domain protein isoform X47

    UniProtKB/TrEMBL
    A2AGR1
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  17. XM_036161255.1 → XP_036017148.1  MAP kinase-activating death domain protein isoform X46

    UniProtKB/TrEMBL
    A2AGR1
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  18. XM_030250257.2 → XP_030106117.1  MAP kinase-activating death domain protein isoform X48

    UniProtKB/TrEMBL
    A2AGR1
    Related
    ENSMUSP00000107000.2, ENSMUST00000111369.8
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  19. XM_036161254.1 → XP_036017147.1  MAP kinase-activating death domain protein isoform X45

    UniProtKB/TrEMBL
    A2AGR1
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  20. XM_036161253.1 → XP_036017146.1  MAP kinase-activating death domain protein isoform X44

    UniProtKB/TrEMBL
    A2AGR1
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  21. XM_036161221.1 → XP_036017114.1  MAP kinase-activating death domain protein isoform X21

    UniProtKB/TrEMBL
    A2AGQ3
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  22. XM_036161250.1 → XP_036017143.1  MAP kinase-activating death domain protein isoform X42

    UniProtKB/TrEMBL
    A2AGR1
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  23. XM_036161218.1 → XP_036017111.1  MAP kinase-activating death domain protein isoform X18

    UniProtKB/TrEMBL
    A2AGQ3
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  24. XM_036161248.1 → XP_036017141.1  MAP kinase-activating death domain protein isoform X41

    UniProtKB/TrEMBL
    A2AGR1
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  25. XM_036161251.1 → XP_036017144.1  MAP kinase-activating death domain protein isoform X43

    UniProtKB/TrEMBL
    A2AGR1
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  26. XM_036161219.1 → XP_036017112.1  MAP kinase-activating death domain protein isoform X19

    UniProtKB/TrEMBL
    A2AGQ8
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  27. XM_030250253.2 → XP_030106113.1  MAP kinase-activating death domain protein isoform X40

    UniProtKB/TrEMBL
    A2AGR1
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  28. XM_036161244.1 → XP_036017137.1  MAP kinase-activating death domain protein isoform X39

    UniProtKB/TrEMBL
    A2AGR1
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  29. XM_036161243.1 → XP_036017136.1  MAP kinase-activating death domain protein isoform X38

    UniProtKB/Swiss-Prot
    Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  30. XM_036161213.1 → XP_036017106.1  MAP kinase-activating death domain protein isoform X14

    UniProtKB/TrEMBL
    A2AGQ8
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  31. XM_036161241.1 → XP_036017134.1  MAP kinase-activating death domain protein isoform X36

    UniProtKB/Swiss-Prot
    Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  32. XM_036161240.1 → XP_036017133.1  MAP kinase-activating death domain protein isoform X35

    UniProtKB/Swiss-Prot
    Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  33. XM_036161239.1 → XP_036017132.1  MAP kinase-activating death domain protein isoform X34

    UniProtKB/Swiss-Prot
    Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  34. XM_030250236.2 → XP_030106096.1  MAP kinase-activating death domain protein isoform X12

    UniProtKB/TrEMBL
    A2AGQ6
    Related
    ENSMUSP00000107007.2, ENSMUST00000111376.8
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  35. XM_036161234.1 → XP_036017127.1  MAP kinase-activating death domain protein isoform X32

    UniProtKB/Swiss-Prot
    Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  36. XM_030250225.2 → XP_030106085.1  MAP kinase-activating death domain protein isoform X10

    UniProtKB/TrEMBL
    A2AGQ6
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  37. XM_036161242.1 → XP_036017135.1  MAP kinase-activating death domain protein isoform X37

    UniProtKB/Swiss-Prot
    Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  38. XM_030250246.2 → XP_030106106.1  MAP kinase-activating death domain protein isoform X29

    UniProtKB/Swiss-Prot
    Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  39. XM_036161202.1 → XP_036017095.1  MAP kinase-activating death domain protein isoform X9

    UniProtKB/TrEMBL
    A2AGQ6
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  40. XM_036161231.1 → XP_036017124.1  MAP kinase-activating death domain protein isoform X27

    UniProtKB/Swiss-Prot
    Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  41. XM_036161199.1 → XP_036017092.1  MAP kinase-activating death domain protein isoform X7

    UniProtKB/TrEMBL
    A2AGQ6
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  42. XM_036161232.1 → XP_036017125.1  MAP kinase-activating death domain protein isoform X28

    UniProtKB/Swiss-Prot
    Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  43. XM_036161228.1 → XP_036017121.1  MAP kinase-activating death domain protein isoform X25

    UniProtKB/Swiss-Prot
    Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  44. XM_030250217.2 → XP_030106077.1  MAP kinase-activating death domain protein isoform X6

    UniProtKB/TrEMBL
    A2AGQ6
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  45. XM_030250244.2 → XP_030106104.1  MAP kinase-activating death domain protein isoform X22

    UniProtKB/Swiss-Prot
    Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  46. XM_030250209.2 → XP_030106069.1  MAP kinase-activating death domain protein isoform X4

    UniProtKB/TrEMBL
    A2AGQ4
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  47. XM_030250242.2 → XP_030106102.1  MAP kinase-activating death domain protein isoform X20

    UniProtKB/Swiss-Prot
    Q3TQK3, Q6P4I6, Q80U28, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

  48. XM_030250207.2 → XP_030106067.1  MAP kinase-activating death domain protein isoform X2

    UniProtKB/TrEMBL
    A2AGQ4
    Related
    ENSMUSP00000077094.7, ENSMUST00000077941.13
    Conserved Domains (4) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam15231
    Location:101 → 150
    VCX_VCY; Variable charge X/Y family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001177721.1: Suppressed sequence

    Description
    NM_001177721.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

  2. NM_001177722.1: Suppressed sequence

    Description
    NM_001177722.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

  3. NM_001177723.1: Suppressed sequence

    Description
    NM_001177723.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

  4. NM_001177724.1: Suppressed sequence

    Description
    NM_001177724.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

  5. NM_001177725.1: Suppressed sequence

    Description
    NM_001177725.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

  6. NM_001177726.1: Suppressed sequence

    Description
    NM_001177726.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

  7. NM_001177727.1: Suppressed sequence

    Description
    NM_001177727.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

  8. NM_001177728.1: Suppressed sequence

    Description
    NM_001177728.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

  9. NM_001177729.1: Suppressed sequence

    Description
    NM_001177729.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

  10. NM_178369.1: Suppressed sequence

    Description
    NM_178369.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80U28.2 GenPept UniProtKB/Swiss-Prot:Q80U28

Gene LinkOut

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