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Tnks1bp1 tankyrase 1 binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 228140, updated on 5-Mar-2024

Summary

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Official Symbol
Tnks1bp1provided by MGI
Official Full Name
tankyrase 1 binding protein 1provided by MGI
Primary source
MGI:MGI:2446193
See related
Ensembl:ENSMUSG00000033955 AllianceGenome:MGI:2446193
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tab182; mKIAA1741
Summary
Predicted to enable ankyrin repeat binding activity and enzyme binding activity. Predicted to be involved in cellular response to ionizing radiation; double-strand break repair; and positive regulation of protein phosphorylation. Predicted to be located in several cellular components, including actin cytoskeleton; adherens junction; and plasma membrane. Predicted to be part of CCR4-NOT complex. Predicted to be active in heterochromatin and nucleus. Orthologous to human TNKS1BP1 (tankyrase 1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 19.5), colon adult (RPKM 15.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 D; 2 49.45 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84878356..84903392)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (85048013..85073048)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene proteoglycan 3 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 3 Neighboring gene STARR-positive B cell enhancer ABC_E225 Neighboring gene structure specific recognition protein 1 Neighboring gene RIKEN cDNA 4930443O20 gene Neighboring gene STARR-seq mESC enhancer starr_05013 Neighboring gene apelin receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747
  2. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ankyrin repeat binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to ionizing radiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CCR4-NOT complex ISO
Inferred from Sequence Orthology
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
182 kDa tankyrase-1-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081260.2 → NP_001074729.1  182 kDa tankyrase-1-binding protein

    See identical proteins and their annotated locations for NP_001074729.1

    Status: VALIDATED

    Source sequence(s)
    BC058639, BY023631, CB723061, CF733903
    Consensus CDS
    CCDS38166.1
    UniProtKB/Swiss-Prot
    A2BH84, P58871, Q6ZPI8
    UniProtKB/TrEMBL
    B9EKJ7
    Related
    ENSMUSP00000107232.3, ENSMUST00000111605.9
    Conserved Domains (2) summary
    PHA03247
    Location:26 → 700
    PHA03247; large tegument protein UL36; Provisional
    pfam15327
    Location:1549 → 1712
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    84878356..84903392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317616.3 → XP_017173105.1  182 kDa tankyrase-1-binding protein isoform X2

    UniProtKB/Swiss-Prot
    A2BH84, P58871, Q6ZPI8
    UniProtKB/TrEMBL
    B9EKJ7
    Conserved Domains (2) summary
    PHA03247
    Location:26 → 700
    PHA03247; large tegument protein UL36; Provisional
    pfam15327
    Location:1549 → 1712
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

  2. XM_030250197.2 → XP_030106057.1  182 kDa tankyrase-1-binding protein isoform X2

    UniProtKB/Swiss-Prot
    A2BH84, P58871, Q6ZPI8
    UniProtKB/TrEMBL
    B9EKJ7
    Conserved Domains (2) summary
    PHA03247
    Location:26 → 700
    PHA03247; large tegument protein UL36; Provisional
    pfam15327
    Location:1549 → 1712
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

  3. XM_006499211.4 → XP_006499274.1  182 kDa tankyrase-1-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006499274.1

    UniProtKB/TrEMBL
    B9EKJ7
    Conserved Domains (2) summary
    PHA03247
    Location:26 → 706
    PHA03247; large tegument protein UL36; Provisional
    pfam15327
    Location:1554 → 1718
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

  4. XM_006499214.4 → XP_006499277.1  182 kDa tankyrase-1-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006499277.1

    UniProtKB/TrEMBL
    B9EKJ7
    Conserved Domains (2) summary
    PHA03247
    Location:26 → 706
    PHA03247; large tegument protein UL36; Provisional
    pfam15327
    Location:1554 → 1718
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

  5. XM_006499213.5 → XP_006499276.1  182 kDa tankyrase-1-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006499276.1

    UniProtKB/TrEMBL
    B9EKJ7
    Conserved Domains (2) summary
    PHA03247
    Location:26 → 706
    PHA03247; large tegument protein UL36; Provisional
    pfam15327
    Location:1554 → 1718
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

  6. XM_030250196.2 → XP_030106056.1  182 kDa tankyrase-1-binding protein isoform X2

    UniProtKB/Swiss-Prot
    A2BH84, P58871, Q6ZPI8
    UniProtKB/TrEMBL
    B9EKJ7
    Conserved Domains (2) summary
    PHA03247
    Location:26 → 700
    PHA03247; large tegument protein UL36; Provisional
    pfam15327
    Location:1549 → 1712
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

  7. XM_006499215.5 → XP_006499278.1  182 kDa tankyrase-1-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006499278.1

    UniProtKB/TrEMBL
    B9EKJ7
    Conserved Domains (2) summary
    PHA03247
    Location:26 → 706
    PHA03247; large tegument protein UL36; Provisional
    pfam15327
    Location:1554 → 1718
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

  8. XM_036161180.1 → XP_036017073.1  182 kDa tankyrase-1-binding protein isoform X2

    UniProtKB/Swiss-Prot
    A2BH84, P58871, Q6ZPI8
    UniProtKB/TrEMBL
    B9EKJ7
    Conserved Domains (2) summary
    PHA03247
    Location:26 → 700
    PHA03247; large tegument protein UL36; Provisional
    pfam15327
    Location:1549 → 1712
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

  9. XM_006499212.4 → XP_006499275.1  182 kDa tankyrase-1-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006499275.1

    UniProtKB/TrEMBL
    B9EKJ7
    Conserved Domains (2) summary
    PHA03247
    Location:26 → 706
    PHA03247; large tegument protein UL36; Provisional
    pfam15327
    Location:1554 → 1718
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

  10. XM_006499217.5 → XP_006499280.1  182 kDa tankyrase-1-binding protein isoform X3

    UniProtKB/TrEMBL
    Z4YJL4
    Related
    ENSMUSP00000045767.4, ENSMUST00000048400.4
    Conserved Domains (2) summary
    PHA03307
    Location:630 → 830
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15327
    Location:873 → 1037
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

RNA

  1. XR_004939866.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58871.2 GenPept UniProtKB/Swiss-Prot:P58871

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