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Ppig peptidyl-prolyl isomerase G (cyclophilin G) [ Mus musculus (house mouse) ]

Gene ID: 228005, updated on 11-Apr-2024

Summary

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Official Symbol
Ppigprovided by MGI
Official Full Name
peptidyl-prolyl isomerase G (cyclophilin G)provided by MGI
Primary source
MGI:MGI:2445173
See related
Ensembl:ENSMUSG00000042133 AllianceGenome:MGI:2445173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CYP; SRCyp; B230312B02Rik
Summary
Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Predicted to be located in cytosol; nuclear matrix; and nuclear speck. Predicted to be active in cytoplasm and nucleus. Orthologous to human PPIG (peptidylprolyl isomerase G). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 10.4), CNS E14 (RPKM 6.5) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C2; 2 40.95 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (69553152..69584356)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (69722753..69754059)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene kelch-like 41 Neighboring gene FAST kinase domains 1 Neighboring gene STARR-seq mESC enhancer starr_04743 Neighboring gene STARR-positive B cell enhancer ABC_E10110 Neighboring gene STARR-positive B cell enhancer mm9_chr2:69582878-69583179 Neighboring gene 60S ribosomal protein L13-like Neighboring gene cilia and flagella associated protein 210 Neighboring gene STARR-seq mESC enhancer starr_04744 Neighboring gene STARR-positive B cell enhancer ABC_E4461 Neighboring gene phosphatase, orphan 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins. HĂ©mono M, et al. BMC Biol, 2022 Jan 10. PMID 35012549, Free PMC Article
  2. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  3. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
  4. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclosporin A binding ISO
Inferred from Sequence Orthology
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein peptidyl-prolyl isomerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase G
Names
PPIase G
cyclophilin G
peptidylprolyl isomerase G
rotamase G
NP_001074555.1
NP_001394390.1
NP_001394391.1
NP_001394392.1
NP_001394393.1
NP_001394394.1
NP_001394395.1
NP_001394397.1
NP_001394402.1
NP_001394403.1
NP_001394404.1
NP_001394405.1
NP_001394406.1
NP_001394407.1
NP_001394408.1
NP_001394409.1
NP_001394410.1
NP_001394411.1
NP_001394412.1
NP_001394413.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081086.2 → NP_001074555.1  peptidyl-prolyl cis-trans isomerase G isoform 1

    See identical proteins and their annotated locations for NP_001074555.1

    Status: VALIDATED

    Source sequence(s)
    AL845261
    Consensus CDS
    CCDS38137.1
    UniProtKB/Swiss-Prot
    A2AR02, O70134, Q3TP68, Q3UXE0
    UniProtKB/TrEMBL
    B2RWT5
    Related
    ENSMUSP00000045945.9, ENSMUST00000040915.15
    Conserved Domains (2) summary
    PTZ00121
    Location:401 → 750
    PTZ00121; MAEBL; Provisional
    cl00197
    Location:8 → 175
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

  2. NM_001407461.1 → NP_001394390.1  peptidyl-prolyl cis-trans isomerase G isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL845261
    UniProtKB/Swiss-Prot
    A2AR02, O70134, Q3TP68, Q3UXE0

  3. NM_001407462.1 → NP_001394391.1  peptidyl-prolyl cis-trans isomerase G isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL845261
    UniProtKB/Swiss-Prot
    A2AR02, O70134, Q3TP68, Q3UXE0

  4. NM_001407463.1 → NP_001394392.1  peptidyl-prolyl cis-trans isomerase G isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL845261
    UniProtKB/Swiss-Prot
    A2AR02, O70134, Q3TP68, Q3UXE0
    Related
    ENSMUSP00000088370.4, ENSMUST00000090858.10

  5. NM_001407464.1 → NP_001394393.1  peptidyl-prolyl cis-trans isomerase G isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL845261
    UniProtKB/Swiss-Prot
    A2AR02, O70134, Q3TP68, Q3UXE0

  6. NM_001407465.1 → NP_001394394.1  peptidyl-prolyl cis-trans isomerase G isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL845261
    UniProtKB/Swiss-Prot
    A2AR02, O70134, Q3TP68, Q3UXE0

  7. NM_001407466.1 → NP_001394395.1  peptidyl-prolyl cis-trans isomerase G isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL845261
    UniProtKB/Swiss-Prot
    A2AR02, O70134, Q3TP68, Q3UXE0

  8. NM_001407468.1 → NP_001394397.1  peptidyl-prolyl cis-trans isomerase G isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL845261

  9. NM_001407473.1 → NP_001394402.1  peptidyl-prolyl cis-trans isomerase G isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL845261

  10. NM_001407474.1 → NP_001394403.1  peptidyl-prolyl cis-trans isomerase G isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL845261

  11. NM_001407475.1 → NP_001394404.1  peptidyl-prolyl cis-trans isomerase G isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL845261

  12. NM_001407476.1 → NP_001394405.1  peptidyl-prolyl cis-trans isomerase G isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL845261

  13. NM_001407477.1 → NP_001394406.1  peptidyl-prolyl cis-trans isomerase G isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL845261

  14. NM_001407478.1 → NP_001394407.1  peptidyl-prolyl cis-trans isomerase G isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL845261

  15. NM_001407479.1 → NP_001394408.1  peptidyl-prolyl cis-trans isomerase G isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL845261

  16. NM_001407480.1 → NP_001394409.1  peptidyl-prolyl cis-trans isomerase G isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL845261

  17. NM_001407481.1 → NP_001394410.1  peptidyl-prolyl cis-trans isomerase G isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL845261

  18. NM_001407482.1 → NP_001394411.1  peptidyl-prolyl cis-trans isomerase G isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL845261

  19. NM_001407483.1 → NP_001394412.1  peptidyl-prolyl cis-trans isomerase G isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL845261

  20. NM_001407484.1 → NP_001394413.1  peptidyl-prolyl cis-trans isomerase G isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL845261

RNA

  1. NR_176367.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL845261

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    69553152..69584356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AR02.1 GenPept UniProtKB/Swiss-Prot:A2AR02

Gene LinkOut

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