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Epc2 enhancer of polycomb homolog 2 [ Mus musculus (house mouse) ]

Gene ID: 227867, updated on 11-Apr-2024

Summary

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Official Symbol
Epc2provided by MGI
Official Full Name
enhancer of polycomb homolog 2provided by MGI
Primary source
MGI:MGI:1278321
See related
Ensembl:ENSMUSG00000069495 AllianceGenome:MGI:1278321
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5830499L14; D2Ertd694e
Summary
Predicted to contribute to histone acetyltransferase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within DNA repair and chromatin organization. Predicted to be located in nucleus. Predicted to be part of Piccolo NuA4 histone acetyltransferase complex. Orthologous to human EPC2 (enhancer of polycomb homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 9.1), CNS E14 (RPKM 8.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C1.1; 2 28.62 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (49341498..49441954)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (49450755..49551947)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04438 Neighboring gene 40S ribosomal protein S3a pseudogene Neighboring gene STARR-seq mESC enhancer starr_04439 Neighboring gene predicted gene, 25215 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:49307666-49307775 Neighboring gene STARR-positive B cell enhancer ABC_E807 Neighboring gene STARR-seq mESC enhancer starr_04442 Neighboring gene kinesin family member 5C Neighboring gene STARR-positive B cell enhancer mm9_chr2:49589986-49590287 Neighboring gene predicted gene, 46738 Neighboring gene STARR-seq mESC enhancer starr_04444 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:49672814-49673015 Neighboring gene LY6/PLAUR domain containing 6B Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:49703331-49703484 Neighboring gene STARR-seq mESC enhancer starr_04445

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers. Fisher CL, et al. Nucleic Acids Res, 2017 Dec 1. PMID 28981838, Free PMC Article
  2. The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals. Stankunas K, et al. Development, 1998 Oct. PMID 9735366
  3. A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum. Farini D, et al. Cell Rep, 2020 Jun 2. PMID 32492419
  4. Hdac6 regulates Tip60-p400 function in stem cells. Chen PB, et al. Elife, 2013 Dec 3. PMID 24302573, Free PMC Article
  5. The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation. Jacquet K, et al. Mol Cell, 2016 May 5. PMID 27153538, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp566F2124

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of piccolo histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
enhancer of polycomb homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172663.4 → NP_766251.3  enhancer of polycomb homolog 2

    See identical proteins and their annotated locations for NP_766251.3

    Status: VALIDATED

    Source sequence(s)
    AK031025, AK141073, AK164886, BB620197, BY253789
    Consensus CDS
    CCDS16023.1
    UniProtKB/Swiss-Prot
    A2AQU9, Q3URX9, Q80Y70, Q8BXC5, Q8C0I4
    Related
    ENSMUSP00000089758.5, ENSMUST00000092123.11
    Conserved Domains (2) summary
    pfam06752
    Location:578 → 808
    E_Pc_C; Enhancer of Polycomb C-terminus
    pfam10513
    Location:7 → 148
    EPL1; Enhancer of polycomb-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    49341498..49441954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498011.4 → XP_006498074.1  enhancer of polycomb homolog 2 isoform X1

    Conserved Domains (2) summary
    pfam06752
    Location:514 → 744
    E_Pc_C; Enhancer of Polycomb C-terminus
    pfam10513
    Location:7 → 148
    EPL1; Enhancer of polycomb-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0I4.2 GenPept UniProtKB/Swiss-Prot:Q8C0I4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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