U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc30a4 solute carrier family 30 (zinc transporter), member 4 [ Mus musculus (house mouse) ]

Gene ID: 22785, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Slc30a4provided by MGI
Official Full Name
solute carrier family 30 (zinc transporter), member 4provided by MGI
Primary source
MGI:MGI:1345282
See related
Ensembl:ENSMUSG00000005802 AllianceGenome:MGI:1345282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
lm; Znt4; znT-4
Summary
Predicted to enable zinc ion transmembrane transporter activity. Acts upstream of or within zinc ion homeostasis. Predicted to be located in late endosome. Predicted to be active in plasma membrane. Is expressed in medulla oblongata basal plate mantle layer and placenta. Orthologous to human SLC30A4 (solute carrier family 30 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 14.9), placenta adult (RPKM 9.8) and 26 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2 E5; 2 60.65 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (122523153..122544583, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122681233..122702663, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene AFG2 AAA ATPase homolog B Neighboring gene expressed sequence AA467197 Neighboring gene microRNA 147 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:122478177-122478415 Neighboring gene STARR-seq mESC enhancer starr_05561 Neighboring gene STARR-positive B cell enhancer ABC_E10135 Neighboring gene STARR-positive B cell enhancer mm9_chr2:122493578-122493879 Neighboring gene RIKEN cDNA 4930417H01 gene Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 6, pallidin, opposite strand

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ZnT4 (SLC30A4)-null ("lethal milk") mice have defects in mammary gland secretion and hallmarks of precocious involution during lactation. McCormick NH, et al. Am J Physiol Regul Integr Comp Physiol, 2016 Jan 1. PMID 26538236, Free PMC Article
  2. ZnT4 provides zinc to zinc-dependent proteins in the trans-Golgi network critical for cell function and Zn export in mammary epithelial cells. McCormick NH, et al. Am J Physiol Cell Physiol, 2012 Aug 1. PMID 22621784, Free PMC Article
  3. Mammalian zinc transporters. McMahon RJ, et al. J Nutr, 1998 Apr. PMID 9521625
  4. Induction of metallothionein by zinc in lethal milk mutant mice. Piletz JE, et al. Biochem Genet, 1982 Dec. PMID 7165696
  5. Zinc metabolism in lethal-milk mice. Otolith, lactation, and aging effects. Erway LC, et al. J Hered, 1984 Nov-Dec. PMID 6512240

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-30a regulates acute cerebral ischemia-induced blood-brain barrier damage through ZnT4/zinc pathway.
    Title: MicroRNA-30a regulates acute cerebral ischemia-induced blood-brain barrier damage through ZnT4/zinc pathway.
  2. Loss of ZnT4 has profound consequences on mammary epithelial cell secretion and may promote tissue remodeling in the mammary gland during early lactation.
    Title: ZnT4 (SLC30A4)-null ("lethal milk") mice have defects in mammary gland secretion and hallmarks of precocious involution during lactation.
  3. It was shown that that ZnT4 transports Zn into the trans-Golgi network, which is critical for key secretory functions of the mammary cell.
    Title: ZnT4 provides zinc to zinc-dependent proteins in the trans-Golgi network critical for cell function and Zn export in mammary epithelial cells.
  4. Expression of zinc transporter ZnT4 in mouse choroid epithelial cells suggests that the choroid plexus plays an important role in regulation of zinc homeostasis in the brain.
    Title: Dynamic zinc pools in mouse choroid plexus.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (1) 
  • Endonuclease-mediated (4) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to toxic substance ISO
Inferred from Sequence Orthology
more info
  
involved_in response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within zinc export across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in zinc ion import into lysosome ISO
Inferred from Sequence Orthology
more info
  
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zinc ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in zinc ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within zinc ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
probable proton-coupled zinc antiporter SLC30A4
Names
lethal milk protein
solute carrier family 30 (zinc transporter), member 4; zinc transporter 4
solute carrier family 30 member 4
zinc transporter 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290993.1 → NP_001277922.1  probable proton-coupled zinc antiporter SLC30A4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK134245, AL772253, AW125676, CO432407, CV556160
    Consensus CDS
    CCDS71131.1
    UniProtKB/TrEMBL
    A2AK40, Q3TM66
    Related
    ENSMUSP00000097056.4, ENSMUST00000099457.4
    Conserved Domains (2) summary
    TIGR01297
    Location:131 → 365
    CDF; cation diffusion facilitator family transporter
    pfam01545
    Location:130 → 284
    Cation_efflux; Cation efflux family

  2. NM_011774.3 → NP_035904.2  probable proton-coupled zinc antiporter SLC30A4 isoform a

    See identical proteins and their annotated locations for NP_035904.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK134245, AL772253, AW125676, CO432407, CV556160
    Consensus CDS
    CCDS16667.1
    UniProtKB/Swiss-Prot
    O35149, O35154, Q3UYZ9
    UniProtKB/TrEMBL
    Q3TM66
    Related
    ENSMUSP00000005952.5, ENSMUST00000005952.11
    Conserved Domains (2) summary
    TIGR01297
    Location:123 → 414
    CDF; cation diffusion facilitator family transporter
    pfam01545
    Location:123 → 333
    Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    122523153..122544583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35149.2 GenPept UniProtKB/Swiss-Prot:O35149

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous